6 - Erythroblasts and Myelocytes
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[01:30] ---
EPISODE 6:
ERYTHROBLASTS AND MYELOCYTES
[01:32] ---
"Erythroblasts and Myelocytes."
[01:39] ---
Inside the human body,
[01:41] ---
roughly 37.2 trillion cells
work energetically,
[01:44] ---
DENDRITE
[01:45] ---
24 hours and 365 days.
[01:49] ---
They are all working very hard.
[01:52] ---
This is the inside of a human body.
[01:55] ---
I've lost my way again!
[01:57] ---
The inside of the body is too complicated!
SIGN RED BLOOD CELLS:
They carry oxygen
and carbon dioxide
using blood circulation.
[02:01] ---
FRAGILE
CONDENSED GAS
[02:03] ---
Huh? Where am I now?
[02:08] ---
Huh? By any chance, could this be?
[02:12] ---
It's the Red Bone Marrow!
[02:14] ---
RED BONE MARROW
[02:15] ---
Red Bone Marrow.
[02:17] ---
This is the blood cells' homeland.
[02:24] ---
Valedictorian, please step forward!
[02:27] ---
Yes, ma'am!
[02:39] ---
Congratulations on graduating.
SIGN ENUCLEATION:
When an Erythroblast releases
its core and becomes
a Red Blood Cell.
[02:41] ---
You're a full-fledged Red Blood Cell now,
starting today.
[02:44] ---
Thank you very much.
[02:47] ---
That brings back memories!
[02:50] ---
It's Enucleation Day.
[02:53] ---
This is where the blood cells are born
and reside until they've grown up.
[02:58] ---
This is where I...
[03:01] ---
Years ago...
SIGN PRECURSOR CELLS:
Cells before they're differentiated
from Stem Cells into certain other cells.
[03:13] ---
Confirming the birth of a Precursor Cell!
[03:21] ---
This child...
[03:22] ---
We can make her a Red Blood Cell, right?
She's a redhead.
SIGN HEMOPOIETIC STEM CELLS:
Cells that produce blood cells
such as Red Blood Cells,
White Blood Cells, Platelets, etc.
[03:25] ---
Sounds good to me.
[03:28] ---
Do we have enough Eosinophils?
[03:30] ---
We just need two more.
Let me know if you see any good ones!
[03:33] ---
NEUTROPHILS
[03:34] ---
It is here that the blood cells
are produced by Hemopoietic Stem Cells,
[03:38] ---
and sorted by category.
[03:41] ---
Red Blood Cells come into this world
as Precursor Cells,
[03:45] ---
mature into cells called "Erythroblasts,"
[03:49] ---
and are nurtured by Macrophages
inside this Red Bone Marrow.
SIGN ERYTHROBLASTS:
Cells that are still being differentiated
before they become Red Blood Cells.
They exist inside the bone marrow.
[03:55] ---
Erythroblasts.
[03:56] ---
Cells that are still being differentiated
before they become Red Blood Cells.
[04:00] ---
They exist inside the bone marrow.
[04:03] ---
All right, children, are we all here now?
[04:06] ---
Yes!
[04:07] ---
I'm the Macrophage in charge of this class.
[04:10] ---
I'll be looking after you until you become
full-fledged Red Blood Cells, all right?
SIGN MACROPHAGE:
Inside the bone marrow,
Erythroblasts cluster
around the Macrophages,
which play a crucial role
in their differentiation
and maturation.
[04:15] ---
Let's all do our best to become
exemplary Red Blood Cells!
[04:19] ---
Okay!
[04:22] ---
BLOOD CIRCULATION
IS FUN
[04:24] ---
Let's get this down pat!
[04:26] ---
Okay.
[04:30] ---
Now then, I wonder
if you can do a good job delivering!
[04:32] ---
START
[04:34] ---
Yes!
[04:37] ---
Let's deliver this oxygen!
[04:39] ---
On your marks, get set, go!
[04:42] ---
All right! I'm gonna do this, too!
[04:44] ---
All right, children, good luck!
[04:49] ---
Huh? It's a dead end!
[04:51] ---
This way?
[04:52] ---
No, is it that way? But...
[04:55] ---
This way?
[04:58] ---
It's neither this way nor that way!
[05:01] ---
What the... What the... What the...
[05:05] ---
Teacher! That girl got so lost she's dizzy.
[05:09] ---
Oh my...
[05:12] ---
There, there. No need to cry. You'll be fine.
[05:15] ---
You'll stop getting lost before you know it.
You don't have to panic, all right?
[05:20] ---
Okay.
[05:23] ---
The blood vessel isn't always a peaceful place.
[05:27] ---
Extremely scary bacteria pop up
from time to time!
[05:31] ---
And so today, we're going to practice
running away from bacteria!
[05:37] ---
When bacteria appears,
hurry to a nearby corner and hide!
[05:42] ---
Okay!
[05:44] ---
I've asked Neutrophil to play
the role of the bacterium today.
[05:45] ---
WHITE BLOOD CELL
SIGN WHITE BLOOD CELLS
(NEUTROPHILS):
Their main task is to
eliminate foreign
substances from outside,
such as bacteria and viruses.
[05:49] ---
Nice to meet you!
[05:51] ---
I bet this girl's gonna lose her way
and get eaten up!
[05:55] ---
Don't say that!
[05:57] ---
Hey, hey.
[05:58] ---
Listen up when your teacher's talking!
[06:02] ---
Okay.
[06:03] ---
T-Teacher!
[06:05] ---
What if I end up getting lost?
[06:08] ---
Don't worry.
[06:10] ---
You're all still children,
[06:12] ---
so you won't be able to leave
the bone marrow.
[06:16] ---
If you're here inside the bone marrow,
we can find you for sure!
SIGN Until they mature and
undergo enucleation,
Erythroblasts reside
in the bone marrow.
[06:24] ---
Please don't let me get lost!
[06:29] ---
If you're scared,
wanna run away together?
[06:32] ---
O-Oh! Thanks!
[06:35] ---
All right, let's go!
[06:37] ---
Okay, start!
[06:42] ---
Oh, is it okay for me to get started?
[06:45] ---
If you please.
[06:47] ---
Hey! Look who's here!
It's King Bacterium himself!
[06:51] ---
Any Red Blood Cells around?
[06:55] ---
Any Red Blood Cells around?
[06:57] ---
I wonder if you all managed
to hide yourselves well.
[06:58] ---
Any Red Blood Cells around?
[07:01] ---
Try not to get captured
by that scary bacterium!
[07:05] ---
Wait, where's that child?
[07:08] ---
Somebody help me!
[07:16] ---
Huh? Where am I now?
[07:19] ---
I've lost my way again!
[07:22] ---
That bacterium is scary, and I'm lost.
[07:27] ---
There's no way
I can ever become a Red Blood Cell!
[07:33] ---
Sorry to keep you waiting
for your oxygen!
[07:38] ---
Thank you as always!
[07:40] ---
Not at all! Now if you'll excuse me!
[07:42] ---
I need one over here!
[07:44] ---
Roger that!
[07:44] ---
- One for me, too!
- Right!
[07:47] ---
They're all so business-like.
[07:50] ---
So cool!
[07:53] ---
I wonder if these people
are Red Blood Cells.
[07:58] ---
Will I turn out like them someday, maybe?
[08:03] ---
What's this?
[08:04] ---
Hey you, what are you doing here?
[08:08] ---
Teacher! You see, just now—
[08:13] ---
You're alone, huh?
[08:15] ---
How convenient for me!
[08:18] ---
You're an Erythroblast, aren't you?
A Red Blood Cell in the making.
[08:22] ---
Th-That's you in disguise, right, Teacher?
[08:26] ---
This is an evacuation drill, right?
[08:28] ---
Teacher, huh? Well, it's not really
such a stretch for me to be called that!
[08:33] ---
After all, I'm overwhelmingly
above you in status!
[08:37] ---
Even still,
[08:40] ---
you've got one thing wrong.
[08:42] ---
I'm a genuine Pseudomonas!
SIGN PSEUDOMONAS:
One of the most common types
of persistent bacteria existing
in natural environments.
Can cause pseudomonas infections.
[08:47] ---
Ms. Macrophage!
[08:49] ---
Where do you think you're going?
[08:53] ---
BLOOD VESSEL
[08:57] ---
The door won't open! But why?
[09:01] ---
Erythroblasts cannot leave
the bone marrow.
[09:06] ---
But why?
[09:07] ---
I don't have time for rules like that!
[09:14] ---
A bacterium like me, who can survive
without stealing nutrients or oxygen...
[09:19] ---
Why do you think I made a point
of coming inside this body?
[09:23] ---
Because you see...
[09:26] ---
I just adore tormenting
helpless blood cells, that's why!
SIGN PSEUDOMONAS:
Can divide and proliferate
like crazy even without nutrients.
Once it enters a live body,
it destroys blood cells
and the cell system
with a vengeance.
[09:37] ---
I can't take this anymore!
[09:39] ---
Now then, now then,
[09:42] ---
shall I finish you off now?
[09:47] ---
I do feel sorry for you.
After all, you're so young.
[09:51] ---
And you're going to die
before you can become an adult.
[09:54] ---
Well, but that's your destiny!
[09:57] ---
Deal with it!
[10:01] ---
I-I don't want to die!
[10:04] ---
Not in a place like this!
[10:11] ---
M-My eyes!
[10:16] ---
I mean, there's a chance that I could turn out
like those cool Red Blood Cells, too!
[10:21] ---
You wretched little brat!
[10:29] ---
Playtime is over!
[10:32] ---
Die!
[10:34] ---
Hold up!
[10:35] ---
You darned germ!
[10:37] ---
Don't think you can lay a finger on a blood cell
in this body, and live to tell the tale!
SIGN MYELOCYTE:
Cells in the process of being differentiated,
before they become White Blood Cells
(Neutrophils, Eosinophils or Basophils).
They reside in the bone marrow.
[10:42] ---
Target sighted!
[10:45] ---
Who are you?
[10:46] ---
I don't need to tell a germ my name!
[10:49] ---
Oh? Are you by any chance a Myelocyte?
[10:53] ---
A White Blood Cell in the making?
[10:55] ---
You think you're going to kill me?
[10:57] ---
That's right! I'm gonna take you out!
[11:00] ---
I'm so scared! I'm so scared!
[11:02] ---
Take that, you darned germ!
[11:05] ---
My weapon!
[11:07] ---
All so lively, aren't you?
[11:10] ---
You little brats inside this body!
[11:12] ---
Give it back! Give it back!
[11:12] ---
What impressive blood cells
you're sure to become one day!
[11:15] ---
You darned germ!
[11:20] ---
That is, if you manage
to stay alive that long!
[11:28] ---
Big Brother!
[11:31] ---
This is such a blast!
[11:33] ---
Destroying little squirts' dreams,
smashing their pride to smithereens...
[11:37] ---
No wonder I can't stop
tormenting the weak!
[11:44] ---
Please don't die, Big Brother!
[11:48] ---
I don't dislike kids with courage!
[11:52] ---
If you hand over that Erythroblast,
[11:55] ---
I'll spare just your life!
[11:59] ---
What's it gonna be, little boy?
[12:03] ---
Don't give me that.
[12:06] ---
You really think I'd do something like that?
[12:11] ---
Even if we, White Blood Cells,
have to sacrifice our own lives,
[12:17] ---
always protect other cells!
[12:21] ---
I'm gonna be a great White Blood Cell!
[12:27] ---
All right, that's the spirit! Myelocyte!
[12:40] ---
You're safe now, okay, you two?
[12:42] ---
Thank goodness! We were so worried!
[12:52] ---
Oh my.
[12:56] ---
All right, let's take care
of those wounds right away.
[12:59] ---
Okay.
[13:04] ---
Neutrophil Teacher,
thank you very much for your help!
[13:07] ---
Big Brother!
[13:13] ---
Thank you so much for rescuing me!
[13:17] ---
Will I see you again?
[13:23] ---
I don't know.
[13:26] ---
I don't know, but...
[13:28] ---
But...
[13:30] ---
when we grow up and start working
inside the blood vessels,
[13:35] ---
maybe we'll see each other somewhere.
[13:38] ---
Bye-bye.
[13:41] ---
Bye-bye!
[13:43] ---
Bye-bye!
[13:45] ---
Bye-bye!
[13:51] ---
Ever since I started working,
I've been so busy that I forgot.
[13:56] ---
But that did happen, didn't it?
[14:01] ---
Okay! I'm gonna deliver
this oxygen pronto!
[14:05] ---
TEA
[14:08] ---
I'm sorry! Please forgive me!
[14:10] ---
Are you all right?
[14:12] ---
No, I'm the one who should be sorry.
[14:17] ---
White Blood Cell?
[14:19] ---
Is that you?
[14:21] ---
We sure run into each other a lot.
[14:25] ---
Th-This is fresh tea!
[14:28] ---
You're lost again?
[14:30] ---
Yeah.
[14:32] ---
It's all right. I'll go with you.
[14:35] ---
Since I'm free right now.
[14:37] ---
Thank you so much!
[14:41] ---
White Blood Cell, huh?
[14:45] ---
That boy back then... I wonder
if he's an able White Blood Cell now?
[14:49] ---
It happened so long ago,
I don't really remember his face.
[14:54] ---
Could it be?
[14:58] ---
What is it?
[14:59] ---
Oh no!
[15:00] ---
No, but really, that would be
too much of a coincidence, right?
[15:12] ---
Cells...
[15:13] ---
...at Work!
[15:18] ---
Thank you so much
for showing me the way!
[15:22] ---
Sure. See you.
[15:24] ---
It's been so peaceful lately!
[15:26] ---
We've had zero incidents.
[15:29] ---
This tea is good.
[15:31] ---
I only wish this could last.
[15:38] ---
Some kind of weird cell is on the attack!
[15:42] ---
S-Somebody help me!
[15:46] ---
CELL
[15:58] ---
Who the hell is this?
[16:00] ---
That's some unusual prey!
[16:03] ---
I haven't seen you eliminate
a cell in forever, Neutrophil!
SIGN KILLER T CELLS (CYTOTOXIC T CELLS):
Mobilize under orders
from the Helper T Cells.
They kill virus-infected cells,
Cancer Cells and the like.
[16:08] ---
Is that you, Killer T?
[16:10] ---
I know you looked out
for Naive the other day.
[16:15] ---
Too bad for him.
[16:17] ---
Did he get infected
with a virus, maybe?
[16:19] ---
That's what I thought.
[16:22] ---
Hard to stomach, isn't it?
[16:24] ---
Incidents involving
your own friends.
[16:27] ---
Now then,
[16:28] ---
I'm gonna take this corpse
into custody, all right?
[16:32] ---
Excuse me.
[16:34] ---
Dealing with cell-related trouble...
That's our job!
[16:37] ---
Your main job is to kill bacteria, right?
[16:42] ---
It's not like we don't take care
of cell-related trouble, too.
[16:46] ---
Excuse me!
[16:50] ---
Hey, what's the problem?
[16:52] ---
I mean, I'm bored
since no jobs have been coming in!
[16:58] ---
You're...
[17:00] ---
NK Cell!
SIGN NK CELL (NATURAL KILLER CELL):
They patrol the entire body,
attacking as soon as they spot
Cancer Cells or viruses.
[17:01] ---
NK Cell.
[17:03] ---
They patrol the entire body,
[17:05] ---
attacking as soon as they spot
[17:08] ---
Cancer Cells or viruses.
[17:10] ---
Hey, my bad.
I couldn't find a suitable cushion.
[17:14] ---
Damn you! What do you want?
[17:16] ---
I knew it.
[17:18] ---
This guy's no ordinary virus.
[17:21] ---
He's the type
who proliferates at warp speed.
[17:24] ---
I'm pretty sure
his friends are still around, so...
[17:27] ---
Maybe I'll ask that cell there
to show me the way?
[17:31] ---
Hey you,
[17:33] ---
it's not just this one virus, right?
[17:37] ---
Um, that's correct.
[17:38] ---
There are still some in my area!
[17:40] ---
What? In the cell system?
[17:42] ---
Y-You should've spoken up sooner!
[17:44] ---
Well, that's what I've been trying
to tell you all this time.
[17:47] ---
You damn idiot! Show us the way now!
[17:49] ---
Hold up a second!
[17:51] ---
As it happens, I've been extremely idle.
[17:54] ---
Sorry, but I'm going to take this job!
[17:57] ---
What?
[17:59] ---
One more thing...
[18:00] ---
I don't want you guys
to come along.
[18:02] ---
The last thing I need
is to have you underfoot.
[18:05] ---
So I'll be going off alone!
[18:06] ---
Wh-Why, you, who do you think you—
[18:10] ---
Oops, my hand slipped.
[18:12] ---
Sorry!
[18:13] ---
I'm powerful, so I'll be fine.
[18:16] ---
Hey, Killer T. You all right?
[18:21] ---
And then, you see...
[18:23] ---
A bucket? Sure!
[18:31] ---
Oops, my bad. My hand slipped.
[18:37] ---
We wouldn't want you to catch a cold,
so you go on home, young lady, and sit tight!
[18:42] ---
Oops! My hand slipped again!
[18:44] ---
Sorry! My foot slipped!
[18:46] ---
I apologize! My elbow slipped!
[18:49] ---
That's too much slipping!
You going senile or what?
[18:53] ---
Who are you to talk?
[18:56] ---
I'm gonna kill you!
[18:57] ---
Huh! I'd like to see you try it!
[19:00] ---
They're allies,
but they're killing each other!
[19:02] ---
Just what you'd expect of immunity cells.
[19:04] ---
Th-They sure don't get along.
[19:07] ---
Yeah, they probably don't.
[19:09] ---
Maybe we should just leave them behind.
[19:12] ---
By the way, Cell...
[19:13] ---
About showing us the way...
[19:15] ---
You don't have to come
the whole way, okay?
[19:18] ---
The cells I'm going off to kill
might have been your friends or neighbors.
[19:24] ---
You wouldn't want to see that, do you?
[19:27] ---
No, hey, I'll be fine!
[19:29] ---
I'll take you all the way.
[19:31] ---
Since it's for the sake of this world.
[19:34] ---
And besides, remember?
You just saved my life.
[19:39] ---
Thank you very much.
[19:40] ---
That was the first time
I'd ever been rescued.
[19:44] ---
Don't worry! I totally understand.
[19:47] ---
That this is something
we can't do anything about.
[19:50] ---
That for the sake of world peace,
sometimes your friends can get killed.
[19:55] ---
And also the fact that that's your job.
[19:59] ---
Is that right? I appreciate that.
[20:02] ---
Anyway, who knew there were immunity cells
who were sensitive to that?
[20:07] ---
W-Well, maybe.
[20:10] ---
Not that I can broadcast it
in front of Killer T.
[20:14] ---
I win!
[20:15] ---
I haven't lost yet!
[20:19] ---
CELL SYSTEM
[20:19] ---
I thought that cells were living here...
[20:22] ---
There's no sign of them.
[20:24] ---
That virus's friends are probably laying low.
[20:29] ---
Come on!
[20:33] ---
It's deserted.
[20:36] ---
This is serious.
[20:39] ---
For now, let's report to HQ,
and then we'll patrol the area together.
[20:43] ---
Together? No way in hell is that happening!
[20:46] ---
Then it'll be two against two!
[20:47] ---
And I'm taking our guide with me!
[20:49] ---
Sure, be my guest!
[20:51] ---
It would be so uncool
if the Lone Wolf got herself lost, huh?
[20:54] ---
H-Hey, no fighting!
[20:56] ---
I'm not fighting!
This is a rejection reaction!
[20:59] ---
No way can I focus on my work
if I'm teamed up with someone like that!
[21:03] ---
Oh thank goodness!
[21:05] ---
Now I'm freed
from babysitting the moron!
[21:11] ---
Hey!
[21:12] ---
Don't let your personal feelings
get in the way!
[21:15] ---
Come back here!
[21:16] ---
It'll get worse if we go along with her!
[21:21] ---
I'm talking about compatibility!
Compatibility!
[21:26] ---
You don't know when to shut up, do you?
[21:29] ---
Now, then...
[21:32] ---
We should get started, too, right?
[21:37] ---
Since that pain in the neck
is out of the way,
[21:40] ---
I'll be glad to take you on,
that's what I'm saying.
[21:43] ---
Although if what you want is to die
as someone else, feel free to stand pat.
[21:47] ---
Show me who you really are!
[21:53] ---
So, I'm busted, huh?
[23:24] ---
NEXT EPISODE
PREVIEW
[23:26] ---
I'm getting a bad vibe.
[23:28] ---
Come on, let me enjoy myself a little longer!
[23:30] ---
This is no viral infection!
[23:32] ---
You ripped me off!
[23:33] ---
What happened to that cell kid?
[23:34] ---
There's something strange going on!
[23:36] ---
All three of you are here, I see.
[23:37] ---
EPISODE 7:
CANCER CELL
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