5 - Cedar Pollen Allergies
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(Please feel free to edit the speaker names if incomplete or inaccurate. Names are handled on a best-effort basis depending on the info on the source file. Dialogue is left as is.)
[00:07] ---
Inside the human body,
[00:10] ---
roughly 37.2 trillion cells
work energetically,
[00:11] ---
DENDRITE
[00:14] ---
All day every day.
[00:15] ---
ANTIBODY ENCYCLOPEDIA
[00:16] ---
24 hours and 365 days.
[00:18] ---
WHITE BLOOD CELL
[00:19] ---
They are all working very hard.
[00:20] ---
UNDER
CONSTRUCTION
[00:20] ---
PLATELETS
[00:29] ---
This is the inside of a human body.
[00:31] ---
WARNING
[00:34] ---
The target is approaching!
[00:50] ---
Estimated point of impact, confirmed!
[00:52] ---
- Issue evacuation orders immediately!
- Size, 30 micrometers!
[00:55] ---
Twenty seconds to impact!
[00:57] ---
19, 18...
[00:59] ---
- 17...
- Commander!
[01:00] ---
16, 15...
SIGN HELPER T CELLS:
When notified of invading
external enemies,
they serve as commanders
who formulate appropriate
attack strategies based on
what kind of enemy they're dealing with.
[01:03] ---
Helper T Cells.
[01:05] ---
When notified of invading external enemies,
they serve as commanders who formulate
[01:10] ---
appropriate attack strategies based on
what kind of enemy they're dealing with.
[01:15] ---
- Here it comes.
- 13, 12, 11...
[01:19] ---
- It had to come, didn't it?
- 10, 9, 8...
[01:21] ---
Cedar Pollen Allergies!
SIGN CEDAR POLLEN:
Cedars send their pollen out
on the wind, scattering them
over a distance. Peak time
is February to March.
[01:23] ---
Cedar Pollen.
[01:25] ---
Cedars send their pollen out on the wind,
scattering them over a distance.
[01:28] ---
Peak time is February to March.
[01:31] ---
- Again this year!
- 3, 2, 1...
[03:04] ---
EPISODE 5:
CEDAR POLLEN ALLERGIES
[03:07] ---
"Cedar Pollen Allergies."
[03:11] ---
Look! There's something
on the mucous membrane!
[03:28] ---
Cedar...
SIGN CEDAR POLLEN ALLERGEN:
Allergies occur when
the immune system overreacts
to a certain substance.
[03:30] ---
Cedar Pollen Allergen.
[03:32] ---
Allergies occur when the immune system
overreacts to a certain substance.
[03:39] ---
Macrophages near the eyeball membrane
are reporting an antigen!
[03:42] ---
Really, what an ordeal!
[03:45] ---
Our tea got spilled all over,
and it's been utter chaos!
[03:48] ---
Multiple pollen have hit
the water at Point 135.K50.
[03:53] ---
So the blink didn't happen in time!
[03:55] ---
At this rate, the allergens will go on
and invade the body through the outlet.
[03:59] ---
Shoot! Send out an alert at once!
[04:05] ---
Staff stationed near the eyeball membrane,
please exercise caution.
[04:09] ---
Repeat.
[04:11] ---
External enemies
have invaded through the outlet,
[04:11] ---
ARTERY
[04:11] ---
DIVERGENCE A
CAPILLARY VESSEL
[04:11] ---
RETINA
[04:13] ---
and so any staff stationed near the eyeball
membrane are urged to exercise caution.
SIGN RED BLOOD CELLS:
Red because they contain
large amounts of hemoglobin.
They carry oxygen
and carbon dioxide
using blood circulation.
[04:22] ---
External enemies?
[04:24] ---
Oh no, it's in this area!
[04:26] ---
I'm gonna finish up this job right away!
[04:29] ---
Okay, let's see. The address
I'm supposed to deliver this is there.
[04:32] ---
Right now, I'm...
[04:35] ---
Um, that's my landmark, so it's this—
[04:39] ---
Cedar!
[04:44] ---
Cedar!
[04:47] ---
What's that thing?
[04:49] ---
Why's it saying "Cedar"? Somebody help!
[04:53] ---
Run, you moron!
[04:56] ---
Target sighted!
[05:00] ---
Cedar...
[05:04] ---
White Blood Cell!
SIGN WHITE BLOOD CELLS (NEUTROPHILS): Their main task is to eliminate foreign substances from outside, such as bacteria and viruses. Neutrophils comprise over half of the White Blood Cells in the blood.
[05:06] ---
Red Blood Cell... Are you okay?
[05:08] ---
Y-Yes!
[05:10] ---
Thank you very much!
[05:13] ---
Um... what exactly is that?
[05:16] ---
He was saying something like, "Cedar"!
[05:18] ---
This one? Who knows?
[05:21] ---
But I'll find out once I eat it!
[05:22] ---
Whoa!
SIGN PHAGOCYTIC EFFECTS:
When phagocytes such as Monocells,
Macrophages and Neutrophils
absorb bacteria and other foreign
substances, and break them down.
Also known as "Phagocytosis."
[05:24] ---
Phagocytic Effects.
[05:25] ---
When phagocytes such as Monocells,
Macrophages and Neutrophils
[05:30] ---
absorb bacteria and other foreign
substances, and break them down.
[05:34] ---
Also known as "Phagocytosis."
[05:37] ---
This tastes like an allergen
released by cedar pollen.
[05:41] ---
Not uncommon at this time of year.
[05:43] ---
They're large in size,
[05:45] ---
but unlike bacteria and viruses,
they don't cause illness.
[05:48] ---
Is that right?
[05:50] ---
Well, that said,
they can still be the cause of trouble.
[05:54] ---
We're supposed to kill them, but...
[05:55] ---
I see. So sorry.
[05:58] ---
Hey! Isn't that...
[06:00] ---
Isn't that a Cedar Pollen Allergen?
[06:03] ---
What the hell?
[06:04] ---
So it was him who snuck in
from the membrane outlet?
[06:08] ---
This means that the legend must be...
[06:12] ---
Who are you?
[06:14] ---
Oh, excuse me.
[06:15] ---
I'm Memory Cell.
SIGN MEMORY CELL:
A Lymphocyte that retains memories
of pathogens. They're prepared
for a second invasion by the same
antigen or virus.
[06:17] ---
Memory Cell.
[06:19] ---
A Lymphocyte that retains
memories of pathogens.
[06:22] ---
They're prepared for a second invasion
by the same antigen or virus.
[06:26] ---
Why are you panicking?
[06:27] ---
It's not like Cedar Pollen allergens
are that dangerous.
[06:30] ---
Yeah! Not yet at least!
[06:32] ---
But there's a legend that's been passed down
to us Memory Cells for generations.
[06:38] ---
Legend?
[06:39] ---
What kind of legend?
[06:44] ---
Memory Cell?
[06:46] ---
LEGEND NOTES
[06:53] ---
There's a legend that's been passed down
to us Memory Cells for generations.
[06:59] ---
"When the Meteor of Disaster
arrives from outer space,
[07:02] ---
the mountains will rage, the earth
will grow savage, and the sea will writhe!"
[07:07] ---
Wh-What does that mean?
[07:14] ---
In other words,
[07:15] ---
a massive eruption, diastrophism,
and a great flood will occur at the same time,
[07:19] ---
bringing on an unprecedented catastrophe!
[07:26] ---
Harbinger...
[07:28] ---
of a catastrophe.
[07:30] ---
- That thing?
- Cedar!
[07:32] ---
Oh, there's another one!
[07:33] ---
You'll see, soon enough.
[07:36] ---
Emergency!
[07:38] ---
An abnormal number of Cedar Pollen Allergens
has invaded the body.
[07:41] ---
If you're nearby,
please escape immediately if you can!
[07:43] ---
CELL
[07:45] ---
Cedar, cedar, cedar...
[07:49] ---
Where did all these
Cedar Pollen Allergens come from?
[07:52] ---
Cedar, cedar, cedar...
[07:59] ---
My house!
[08:01] ---
I-It's here!
[08:04] ---
The beginning of the end of the world!
[08:07] ---
Yes, this is the Cedar Pollen Allergies
Emergency Response HQ!
[08:10] ---
- Report the situation. Calm down!
- Yes. Yes!
[08:13] ---
Don't return to the eyeball membrane!
[08:14] ---
Helper T Commander!
[08:16] ---
We're getting bombarded with
damage reports about Cedar Pollen Allergens!
[08:18] ---
Doesn't it seem like there are
more of these guys every year?
[08:22] ---
I mean, it's fine.
After all, we've got a secret weapon.
[08:25] ---
By secret weapon, you mean B Cell, right?
[08:28] ---
That's right!
[08:30] ---
Have him head to the front lines right away!
[08:32] ---
You get away from here, Red Blood Cell!
[08:34] ---
Okay!
[08:35] ---
Cedar, cedar, cedar...
[08:43] ---
No sign of the invasion abating.
[08:45] ---
Could this really be
the harbinger of a catastrophe?
[08:49] ---
SECRETION
[08:50] ---
Leave this to me!
[08:52] ---
As long as I have this!
SIGN B CELL:
Also known as "Antibody-producing Cell."
A type of Lymphocyte that fights antigens,
such as bacteria and viruses by producing
weapons called "antibodies."
[08:53] ---
B Cell.
[08:54] ---
Also known as "Antibody-producing Cell."
[08:57] ---
A type of Lymphocyte that fights antigens,
[09:00] ---
such as bacteria and viruses
by producing weapons called "antibodies."
[09:03] ---
- It's the B Cell!
- With it's antibodies!
[09:06] ---
Memory Cell... Can't that catastrophe
be prevented before it happens?
[09:11] ---
A divine mist shall envelope the land.
[09:14] ---
But that is what shall open the door to Hell.
[09:16] ---
Huh? Why all of a sudden...
[09:18] ---
All right, here goes!
[09:20] ---
Cedar!
[09:21] ---
You're history!
[09:25] ---
Take that!
[09:28] ---
IgE Antibody!
SIGN IgE ANTIBODY:
An antibody produced
by B Cells to fight allergens,
as ordered by the Helper T Cells.
[09:41] ---
SECRETION
[09:41] ---
- He annihilated them all in one shot!
- Amazing!
[09:45] ---
That "divine mist" you just mentioned,
did you mean the IgE antibody?
[09:49] ---
I mean, it's looking like
he's solved the problem.
[09:51] ---
Yeah. For now, at least.
[09:54] ---
But something even worse
is about to happen now!
[09:57] ---
The mist will turn into dark clouds,
[09:59] ---
summon a heavy rainfall
and sweep everything away!
[10:03] ---
I don't know what's gonna happen,
but it sounds scary!
[10:06] ---
I'm telling you, something
mind-blowing is about to happen!
[10:10] ---
There's no telling
what might happen. Not at all.
[10:13] ---
- Yeah, good job, B Cell!
- Hit 'em again!
[10:22] ---
A LOT
[10:22] ---
NORMAL
[10:22] ---
What?
[10:24] ---
What's with these numbers?
[10:29] ---
Cells at Work!
[10:34] ---
Cells at Work!
[10:38] ---
What's with this astronomical usage of IgE?
[10:42] ---
A LOT
[10:42] ---
NORMAL
[10:42] ---
What the heck is going on?
[10:44] ---
ANTIBODY MANUAL
[10:44] ---
HISTAMINE HANDLING MANUAL
[10:44] ---
IMMUNOREACTION
[10:47] ---
I've never seen numbers like this.
SIGN MAST CELL:
Also known as "Fat Cell."
Releases chemical mediators,
such as histamines
and leukotrienes in reaction
to the production of excessive IgE.
Despite being known as "Fat Cells,"
they have nothing to do with fat.
[10:50] ---
Mast Cell.
[10:51] ---
Also known as "Fat Cell."
[10:54] ---
Releases chemical mediators,
such as histamines and leukotrienes
[10:57] ---
in reaction to the production
of excessive IgE.
[11:01] ---
Despite being known as "Fat Cells,"
they have nothing to do with fat.
[11:03] ---
HISTAMINE HANDLING
MANUAL
[11:05] ---
But it does say to produce histamines
commensurate with the amount of IgE...
[11:16] ---
Okay. Hold on a second.
First, let's calm down.
[11:19] ---
That's right. You'll be fine.
You can do it if you try.
[11:22] ---
No panicking allowed.
[11:24] ---
All I have to do is follow the manual.
[11:26] ---
Because that's my job!
[11:30] ---
About this much, perhaps?
[11:35] ---
Well, at any rate,
[11:37] ---
excessive use of IgE antibodies...
[11:39] ---
How should I put it, that's not good, right?
[11:41] ---
Most likely.
[11:43] ---
Hey B Cell!
[11:45] ---
Seems like it's not a good idea
to use too much of that!
[11:48] ---
I don't understand, but the legend says...
[11:50] ---
Huh? Legend?
[11:53] ---
It'll be fine!
[11:55] ---
Hey, either way, no worries!
[11:57] ---
Look, the histamines
are about to come into play!
[12:00] ---
That'll cause inflammation
and eliminate the allergens!
[12:03] ---
- I see.
- Is that so?
[12:10] ---
It's retracting.
[12:11] ---
They're just gonna change
the nozzle probably.
SIGN HISTAMINE:
A chemical substance released
by Mast Cells upon recognizing
foreign substances or injury.
[12:27] ---
Histamine.
[12:28] ---
A chemical substance released by Mast Cells
upon recognizing foreign substances or injury.
[12:40] ---
Is this that great rainfall?
[12:42] ---
It might be!
[12:46] ---
Cedar...
[12:48] ---
Cedar...
[12:49] ---
These guys just keep...
[12:53] ---
So there was elevated use of the antibody
because we'd been invaded
[12:55] ---
by this many Cedar Pollen Allergens!
[12:57] ---
This looks bad!
[12:58] ---
In that case, I need to release
even more histamines!
[13:03] ---
- Wait! Wait!
- Stop it already!
[13:07] ---
Is this the unprecedented catastrophe?
[13:09] ---
N-No, it's not!
This is nothing but the tip of the iceberg!
[13:12] ---
The really huge disaster is about to hit us now!
SIGN THE HISTAMINE'S JOB:
Histamines dilate
the vascular endothelial cells,
allowing White Blood Cells
to permeate the vessels at a higher rate.
[13:20] ---
The Histamine's Job.
[13:22] ---
Histamines dilate the vascular endothelial cells,
[13:25] ---
allowing White Blood Cells
to permeate the vessels at a higher rate.
[13:29] ---
Captain, we're in trouble!
[13:30] ---
We're being flooded by histamines nearby!
[13:33] ---
What? Make her stop them!
Contact Mast Cell!
[13:37] ---
The thing is, she's saying that to eliminate
the Cedar Pollen Allergens, she can't afford to stop!
[13:42] ---
No way! At this rate...
[13:48] ---
It's no good, Captain!
The histamines are flooding us...
[13:51] ---
The secretion center!
[13:55] ---
It short-circuited!
[13:59] ---
Bad news, Captain!
[14:00] ---
What is it now?
[14:02] ---
Because of the damage
to the secretion center...
[14:05] ---
the Emergency Immune System
is about to kick in!
SIGN EMERGENCY IMMUNE SYSTEM=
ALLERGIC REACTION CAUSED BY HISTAMINES
When too many histamines
have been released,
this triggers allergic reactions
such as flushing, itching,
swelling, pain and bronchoconstriction.
[14:08] ---
What?
[14:10] ---
Emergency Immune System, you say?
[14:11] ---
EMERGENCY
[14:16] ---
- Whoa!
- Did they get them?
[14:20] ---
Hey! Look at that!
[14:27] ---
Th-That's...
[14:30] ---
The massive eruption!
[14:34] ---
Sneezing.
SIGN SNEEZING:
Histamines stimulate the sensory nerves
in the nasal membrane.
When this stimulation reaches
the sneezing center,
sneezes occur repetitively.
[14:35] ---
Histamines stimulate the sensory nerves
in the nasal membrane.
[14:39] ---
When this stimulation reaches the sneezing center,
sneezes occur repetitively.
[14:47] ---
Diastrophism?
[14:50] ---
The nasal membrane
is swelling up like crazy!
SIGN NASAL CONGESTION:
Histamines influence the blood vessels
in the nasal membrane,
causing inflammation and the like.
As a result, the nasal membrane swells
and bloats, causing nasal congestion.
[14:53] ---
Nasal Congestion.
[14:55] ---
Histamines influence the blood vessels
in the nasal membrane,
[14:58] ---
causing inflammation and the like.
[15:00] ---
As a result, the nasal membrane swells
and bloats, causing nasal congestion.
[15:08] ---
TEARS
[15:08] ---
The tears are overflowing!
[15:10] ---
A great flood!
SIGN TEARS:
Histamines stimulate the eyes'
sensory nerves, triggering inflammation,
such as bloodshot or itchy eyes.
This also produces excessive tears.
[15:13] ---
Tears.
[15:14] ---
Histamines stimulate
the eyes' sensory nerves,
[15:17] ---
triggering inflammation,
such as bloodshot or itchy eyes.
[15:21] ---
This also produces excessive tears.
[15:24] ---
Achoo! Achoo!
[15:27] ---
Cedar, cedar, cedar...
[15:31] ---
This is what the legend described.
[15:34] ---
Cedar, cedar, cedar...
[15:38] ---
Cedar Pollen Allergies!
SIGN CEDAR POLLEN ALLERGIES:
Allergic symptoms, such as sneezing,
runny nose, nasal congestion, itchy eyes,
triggered when cedar pollen
becomes an allergen.
[15:40] ---
Cedar Pollen Allergies.
[15:42] ---
Allergic symptoms, such as sneezing,
runny nose, nasal congestion, itchy eyes,
[15:47] ---
triggered when cedar pollen
becomes an allergen.
[15:50] ---
Achoo!
[15:55] ---
Dammit!
[15:57] ---
Why is this happening?
[15:59] ---
He's the one who caused this!
How are you gonna fix this?
[16:02] ---
B Cell!
[16:04] ---
It's all because you kept sloshing
those antibodies around!
[16:07] ---
H-H-Hey, it's not my fault!
[16:10] ---
The histamines are to blame, right?
[16:15] ---
It's your fault, Mast Cell!
[16:18] ---
What the heck, you guys?
[16:20] ---
Hey! What's the big idea?
[16:23] ---
Let me go! Don't touch me!
[16:25] ---
It's not my fault!
The IgE is what caused this!
[16:28] ---
Ah, no.
[16:29] ---
The overproduction of histamines
is definitely what caused this!
[16:32] ---
All I did was do my job
according to the manual!
[16:35] ---
It's all your fault, damn you!
[16:37] ---
Can't do your job
unless you follow the manual, Fat Cell?
[16:41] ---
Don't call me by that name!
[16:43] ---
Doesn't the "B" in B Cell
stand for "Bonehead"?
[16:45] ---
What'd you say, dammit?
[16:47] ---
Shut up, Bonehead! Bonehead!
[16:49] ---
Wanna fight, moron?
[16:54] ---
This is getting out of hand.
[16:56] ---
Yeah.
[16:58] ---
But...
[17:03] ---
All everyone did
was fulfill their respective jobs,
[17:08] ---
so who knew it would turn out like this?
[17:12] ---
If only we knew
that this was going to happen...
[17:15] ---
No, even if we had known...
[17:18] ---
We had no choice but to do it.
[17:22] ---
White Blood Cell!
[17:23] ---
No matter what situation we're in,
we can never walk out on our jobs.
[17:27] ---
White Blood Cell!
[17:30] ---
That's our destiny as—
[17:30] ---
White Blood Cell!
[17:34] ---
- Destiny—
- Cell!
[17:35] ---
- Destiny—
- Cell!
[17:40] ---
White Blood Cell!
[17:42] ---
Hey, Red Blood Cell.
[17:45] ---
What is that?
[17:46] ---
I-I-I-I-I'm so sorry!
[17:48] ---
This is, um, not that I'm really sure myself,
but this is where I'm supposed to deliver it!
[17:53] ---
Actually, it looks like there's some kind
of commotion going on, but are you all right?
[17:57] ---
No, I'm not all right.
[18:00] ---
FOR MEDICAL USE
[18:00] ---
Still, what is this thing?
[18:01] ---
I-I don't know.
[18:04] ---
Have you ever seen it before, Memory Cell?
[18:08] ---
No, I've never seen it.
[18:10] ---
Arrived at target destination.
[18:32] ---
Hey, what's that?
[18:33] ---
Something's coming out.
[18:51] ---
Target Cell confirmed.
[18:55] ---
Will now eliminate.
[19:05] ---
What's wrong with him?
[19:06] ---
Why is he attacking us?
[19:13] ---
Eliminating now.
[19:15] ---
ROOMS AVAILABLE
[19:17] ---
APPLICANTS WELCOME
[19:20] ---
My house!
[19:21] ---
Stop!
[19:24] ---
Hey! Now I remember!
[19:27] ---
I've heard about this before!
[19:28] ---
When there's a change to the world,
it appears out of nowhere!
[19:32] ---
This type
[19:34] ---
is the type that wipes out everything
involved in the uproar!
[19:37] ---
His name is...
[19:39] ---
Steroid!
SIGN STEROIDS:
Also known as "Adrenocortical Hormone."
A drug with powerful anti-inflammatory
and immunosuppressive effects.
Suppresses symptoms caused by histamines,
as well as allergic reactions themselves.
[19:41] ---
Steroids.
[19:42] ---
Also known as "Adrenocortical Hormone."
[19:45] ---
A drug with powerful anti-inflammatory
and immunosuppressive effects.
[19:50] ---
Suppresses symptoms caused by histamines,
as well as allergic reactions themselves.
[19:57] ---
S-So powerful!
[20:13] ---
I'm sorry! I have no clue
what's going on, but sorry!
[20:17] ---
We're in trouble, Captain!
[20:19] ---
This weird guy just showed up!
[20:23] ---
Sorry! B Cell and Mast Cell! We're sorry!
[20:27] ---
You guys... you guys...
[20:33] ---
Compared to him,
you were doing your job like a gentleman!
[20:48] ---
Hey, when is this ever gonna stop?
[21:06] ---
Thank you for your patronage.
[21:11] ---
The Steroid went silent
after exhausting his active ingredients.
[21:15] ---
And somewhere along the line,
the Allergens died out spontaneously,
[21:19] ---
and the allergic reaction settled down.
[21:22] ---
Everybody made up with each other.
[21:25] ---
So, thank goodness!
[21:29] ---
Really.
[21:32] ---
Thank goodness.
[21:34] ---
Side Effects of Steroids.
SIGN SIDE EFFECTS OF STEROIDS:
Prolonged use and massive dosage of steroids
can sometimes cause side effects.
It's crucial to adhere to the directions
and recommended dosage.
[21:36] ---
Prolonged use and massive dosage of steroids
can sometimes cause side effects.
[21:42] ---
It's crucial to adhere to the directions
and recommended dosage.
[21:46] ---
I'm going to make sure
I remember what happened today.
[21:47] ---
THANK YOU
FOR YOUR
PATRONAGE.
[23:25] [SONG] ---
NEXT EPISODE
PREVIEW
[23:26] ---
When you were a kid,
what kind of blood cell were you?
[23:29] ---
I was always getting lost!
[23:31] ---
I can see that.
[23:32] ---
Next episode of "Cells at Work!",
[23:34] ---
"Erythroblasts and Myelocytes."
[23:36] ---
EPISODE 6:
ERYTHROBLASTS AND MYELOCYTES
[23:36] ---
All right, time to get to work!
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