6 - Erythroblasts and Myelocytes

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[01:30] ---
    EPISODE 6:
    ERYTHROBLASTS AND MYELOCYTES
[01:32] ---
    "Erythroblasts and Myelocytes."
[01:39] ---
    Inside the human body,
[01:41] ---
    roughly 37.2 trillion cells
    work energetically,
[01:44] ---
    DENDRITE
[01:45] ---
    24 hours and 365 days.
[01:49] ---
    They are all working very hard.
[01:52] ---
    This is the inside of a human body.
[01:55] ---
    I've lost my way again!
[01:57] ---
    The inside of the body is too complicated!
SIGN    RED BLOOD CELLS:
    They carry oxygen
    and carbon dioxide
    using blood circulation.
[02:01] ---
    FRAGILE
    CONDENSED GAS
[02:03] ---
    Huh? Where am I now?
[02:08] ---
    Huh? By any chance, could this be?
[02:12] ---
    It's the Red Bone Marrow!
[02:14] ---
    RED BONE MARROW
[02:15] ---
    Red Bone Marrow.
[02:17] ---
    This is the blood cells' homeland.
[02:24] ---
    Valedictorian, please step forward!
[02:27] ---
    Yes, ma'am!
[02:39] ---
    Congratulations on graduating.
SIGN    ENUCLEATION:
    When an Erythroblast releases
    its core and becomes
    a Red Blood Cell.
[02:41] ---
    You're a full-fledged Red Blood Cell now,
    starting today.
[02:44] ---
    Thank you very much.
[02:47] ---
    That brings back memories!
[02:50] ---
    It's Enucleation Day.
[02:53] ---
    This is where the blood cells are born
    and reside until they've grown up.
[02:58] ---
    This is where I...
[03:01] ---
    Years ago...
SIGN    PRECURSOR CELLS:
    Cells before they're differentiated
    from Stem Cells into certain other cells.
[03:13] ---
    Confirming the birth of a Precursor Cell!
[03:21] ---
    This child...
[03:22] ---
    We can make her a Red Blood Cell, right?
    She's a redhead.
SIGN    HEMOPOIETIC STEM CELLS:
    Cells that produce blood cells
    such as Red Blood Cells,
    White Blood Cells, Platelets, etc.
[03:25] ---
    Sounds good to me.
[03:28] ---
    Do we have enough Eosinophils?
[03:30] ---
    We just need two more.
    Let me know if you see any good ones!
[03:33] ---
    NEUTROPHILS
[03:34] ---
    It is here that the blood cells
    are produced by Hemopoietic Stem Cells,
[03:38] ---
    and sorted by category.
[03:41] ---
    Red Blood Cells come into this world
    as Precursor Cells,
[03:45] ---
    mature into cells called "Erythroblasts,"
[03:49] ---
    and are nurtured by Macrophages
    inside this Red Bone Marrow.
SIGN    ERYTHROBLASTS:
    Cells that are still being differentiated
    before they become Red Blood Cells.
    They exist inside the bone marrow.
[03:55] ---
    Erythroblasts.
[03:56] ---
    Cells that are still being differentiated
    before they become Red Blood Cells.
[04:00] ---
    They exist inside the bone marrow.
[04:03] ---
    All right, children, are we all here now?
[04:06] ---
    Yes!
[04:07] ---
    I'm the Macrophage in charge of this class.
[04:10] ---
    I'll be looking after you until you become
    full-fledged Red Blood Cells, all right?
SIGN    MACROPHAGE:
    Inside the bone marrow,
    Erythroblasts cluster
    around the Macrophages,
    which play a crucial role
    in their differentiation
    and maturation.
[04:15] ---
    Let's all do our best to become
    exemplary Red Blood Cells!
[04:19] ---
    Okay!
[04:22] ---
    BLOOD CIRCULATION
    IS FUN
[04:24] ---
    Let's get this down pat!
[04:26] ---
    Okay.
[04:30] ---
    Now then, I wonder
    if you can do a good job delivering!
[04:32] ---
    START
[04:34] ---
    Yes!
[04:37] ---
    Let's deliver this oxygen!
[04:39] ---
    On your marks, get set, go!
[04:42] ---
    All right! I'm gonna do this, too!
[04:44] ---
    All right, children, good luck!
[04:49] ---
    Huh? It's a dead end!
[04:51] ---
    This way?
[04:52] ---
    No, is it that way? But...
[04:55] ---
    This way?
[04:58] ---
    It's neither this way nor that way!
[05:01] ---
    What the... What the... What the...
[05:05] ---
    Teacher! That girl got so lost she's dizzy.
[05:09] ---
    Oh my...
[05:12] ---
    There, there. No need to cry. You'll be fine.
[05:15] ---
    You'll stop getting lost before you know it.
    You don't have to panic, all right?
[05:20] ---
    Okay.
[05:23] ---
    The blood vessel isn't always a peaceful place.
[05:27] ---
    Extremely scary bacteria pop up
    from time to time!
[05:31] ---
    And so today, we're going to practice
    running away from bacteria!
[05:37] ---
    When bacteria appears,
    hurry to a nearby corner and hide!
[05:42] ---
    Okay!
[05:44] ---
    I've asked Neutrophil to play
    the role of the bacterium today.
[05:45] ---
    WHITE BLOOD CELL
SIGN    WHITE BLOOD CELLS
    (NEUTROPHILS):
    Their main task is to
    eliminate foreign
    substances from outside,
    such as bacteria and viruses.
[05:49] ---
    Nice to meet you!
[05:51] ---
    I bet this girl's gonna lose her way
    and get eaten up!
[05:55] ---
    Don't say that!
[05:57] ---
    Hey, hey.
[05:58] ---
    Listen up when your teacher's talking!
[06:02] ---
    Okay.
[06:03] ---
    T-Teacher!
[06:05] ---
    What if I end up getting lost?
[06:08] ---
    Don't worry.
[06:10] ---
    You're all still children,
[06:12] ---
    so you won't be able to leave
    the bone marrow.
[06:16] ---
    If you're here inside the bone marrow,
    we can find you for sure!
SIGN    Until they mature and
    undergo enucleation,
    Erythroblasts reside
    in the bone marrow.
[06:24] ---
    Please don't let me get lost!
[06:29] ---
    If you're scared,
    wanna run away together?
[06:32] ---
    O-Oh! Thanks!
[06:35] ---
    All right, let's go!
[06:37] ---
    Okay, start!
[06:42] ---
    Oh, is it okay for me to get started?
[06:45] ---
    If you please.
[06:47] ---
    Hey! Look who's here!
    It's King Bacterium himself!
[06:51] ---
    Any Red Blood Cells around?
[06:55] ---
    Any Red Blood Cells around?
[06:57] ---
    I wonder if you all managed
    to hide yourselves well.
[06:58] ---
    Any Red Blood Cells around?
[07:01] ---
    Try not to get captured
    by that scary bacterium!
[07:05] ---
    Wait, where's that child?
[07:08] ---
    Somebody help me!
[07:16] ---
    Huh? Where am I now?
[07:19] ---
    I've lost my way again!
[07:22] ---
    That bacterium is scary, and I'm lost.
[07:27] ---
    There's no way
    I can ever become a Red Blood Cell!
[07:33] ---
    Sorry to keep you waiting
    for your oxygen!
[07:38] ---
    Thank you as always!
[07:40] ---
    Not at all! Now if you'll excuse me!
[07:42] ---
    I need one over here!
[07:44] ---
    Roger that!
[07:44] ---
    - One for me, too!
    - Right!
[07:47] ---
    They're all so business-like.
[07:50] ---
    So cool!
[07:53] ---
    I wonder if these people
    are Red Blood Cells.
[07:58] ---
    Will I turn out like them someday, maybe?
[08:03] ---
    What's this?
[08:04] ---
    Hey you, what are you doing here?
[08:08] ---
    Teacher! You see, just now—
[08:13] ---
    You're alone, huh?
[08:15] ---
    How convenient for me!
[08:18] ---
    You're an Erythroblast, aren't you?
    A Red Blood Cell in the making.
[08:22] ---
    Th-That's you in disguise, right, Teacher?
[08:26] ---
    This is an evacuation drill, right?
[08:28] ---
    Teacher, huh? Well, it's not really
    such a stretch for me to be called that!
[08:33] ---
    After all, I'm overwhelmingly
    above you in status!
[08:37] ---
    Even still,
[08:40] ---
    you've got one thing wrong.
[08:42] ---
    I'm a genuine Pseudomonas!
SIGN    PSEUDOMONAS:
    One of the most common types
    of persistent bacteria existing
    in natural environments.
    Can cause pseudomonas infections.
[08:47] ---
    Ms. Macrophage!
[08:49] ---
    Where do you think you're going?
[08:53] ---
    BLOOD VESSEL
[08:57] ---
    The door won't open! But why?
[09:01] ---
    Erythroblasts cannot leave
    the bone marrow.
[09:06] ---
    But why?
[09:07] ---
    I don't have time for rules like that!
[09:14] ---
    A bacterium like me, who can survive
    without stealing nutrients or oxygen...
[09:19] ---
    Why do you think I made a point
    of coming inside this body?
[09:23] ---
    Because you see...
[09:26] ---
    I just adore tormenting
    helpless blood cells, that's why!
SIGN    PSEUDOMONAS:
    Can divide and proliferate
    like crazy even without nutrients.
    Once it enters a live body,
    it destroys blood cells
    and the cell system
    with a vengeance.
[09:37] ---
    I can't take this anymore!
[09:39] ---
    Now then, now then,
[09:42] ---
    shall I finish you off now?
[09:47] ---
    I do feel sorry for you.
    After all, you're so young.
[09:51] ---
    And you're going to die
    before you can become an adult.
[09:54] ---
    Well, but that's your destiny!
[09:57] ---
    Deal with it!
[10:01] ---
    I-I don't want to die!
[10:04] ---
    Not in a place like this!
[10:11] ---
    M-My eyes!
[10:16] ---
    I mean, there's a chance that I could turn out
    like those cool Red Blood Cells, too!
[10:21] ---
    You wretched little brat!
[10:29] ---
    Playtime is over!
[10:32] ---
    Die!
[10:34] ---
    Hold up!
[10:35] ---
    You darned germ!
[10:37] ---
    Don't think you can lay a finger on a blood cell
    in this body, and live to tell the tale!
SIGN    MYELOCYTE:
    Cells in the process of being differentiated,
    before they become White Blood Cells
    (Neutrophils, Eosinophils or Basophils).
    They reside in the bone marrow.
[10:42] ---
    Target sighted!
[10:45] ---
    Who are you?
[10:46] ---
    I don't need to tell a germ my name!
[10:49] ---
    Oh? Are you by any chance a Myelocyte?
[10:53] ---
    A White Blood Cell in the making?
[10:55] ---
    You think you're going to kill me?
[10:57] ---
    That's right! I'm gonna take you out!
[11:00] ---
    I'm so scared! I'm so scared!
[11:02] ---
    Take that, you darned germ!
[11:05] ---
    My weapon!
[11:07] ---
    All so lively, aren't you?
[11:10] ---
    You little brats inside this body!
[11:12] ---
    Give it back! Give it back!
[11:12] ---
    What impressive blood cells
    you're sure to become one day!
[11:15] ---
    You darned germ!
[11:20] ---
    That is, if you manage
    to stay alive that long!
[11:28] ---
    Big Brother!
[11:31] ---
    This is such a blast!
[11:33] ---
    Destroying little squirts' dreams,
    smashing their pride to smithereens...
[11:37] ---
    No wonder I can't stop
    tormenting the weak!
[11:44] ---
    Please don't die, Big Brother!
[11:48] ---
    I don't dislike kids with courage!
[11:52] ---
    If you hand over that Erythroblast,
[11:55] ---
    I'll spare just your life!
[11:59] ---
    What's it gonna be, little boy?
[12:03] ---
    Don't give me that.
[12:06] ---
    You really think I'd do something like that?
[12:11] ---
    Even if we, White Blood Cells,
    have to sacrifice our own lives,
[12:17] ---
    always protect other cells!
[12:21] ---
    I'm gonna be a great White Blood Cell!
[12:27] ---
    All right, that's the spirit! Myelocyte!
[12:40] ---
    You're safe now, okay, you two?
[12:42] ---
    Thank goodness! We were so worried!
[12:52] ---
    Oh my.
[12:56] ---
    All right, let's take care
    of those wounds right away.
[12:59] ---
    Okay.
[13:04] ---
    Neutrophil Teacher,
    thank you very much for your help!
[13:07] ---
    Big Brother!
[13:13] ---
    Thank you so much for rescuing me!
[13:17] ---
    Will I see you again?
[13:23] ---
    I don't know.
[13:26] ---
    I don't know, but...
[13:28] ---
    But...
[13:30] ---
    when we grow up and start working
    inside the blood vessels,
[13:35] ---
    maybe we'll see each other somewhere.
[13:38] ---
    Bye-bye.
[13:41] ---
    Bye-bye!
[13:43] ---
    Bye-bye!
[13:45] ---
    Bye-bye!
[13:51] ---
    Ever since I started working,
    I've been so busy that I forgot.
[13:56] ---
    But that did happen, didn't it?
[14:01] ---
    Okay! I'm gonna deliver
    this oxygen pronto!
[14:05] ---
    TEA
[14:08] ---
    I'm sorry! Please forgive me!
[14:10] ---
    Are you all right?
[14:12] ---
    No, I'm the one who should be sorry.
[14:17] ---
    White Blood Cell?
[14:19] ---
    Is that you?
[14:21] ---
    We sure run into each other a lot.
[14:25] ---
    Th-This is fresh tea!
[14:28] ---
    You're lost again?
[14:30] ---
    Yeah.
[14:32] ---
    It's all right. I'll go with you.
[14:35] ---
    Since I'm free right now.
[14:37] ---
    Thank you so much!
[14:41] ---
    White Blood Cell, huh?
[14:45] ---
    That boy back then... I wonder
    if he's an able White Blood Cell now?
[14:49] ---
    It happened so long ago,
    I don't really remember his face.
[14:54] ---
    Could it be?
[14:58] ---
    What is it?
[14:59] ---
    Oh no!
[15:00] ---
    No, but really, that would be
    too much of a coincidence, right?
[15:12] ---
    Cells...
[15:13] ---
    ...at Work!
[15:18] ---
    Thank you so much
    for showing me the way!
[15:22] ---
    Sure. See you.
[15:24] ---
    It's been so peaceful lately!
[15:26] ---
    We've had zero incidents.
[15:29] ---
    This tea is good.
[15:31] ---
    I only wish this could last.
[15:38] ---
    Some kind of weird cell is on the attack!
[15:42] ---
    S-Somebody help me!
[15:46] ---
    CELL
[15:58] ---
    Who the hell is this?
[16:00] ---
    That's some unusual prey!
[16:03] ---
    I haven't seen you eliminate
    a cell in forever, Neutrophil!
SIGN    KILLER T CELLS (CYTOTOXIC T CELLS):
    Mobilize under orders
    from the Helper T Cells.
    They kill virus-infected cells,
    Cancer Cells and the like.
[16:08] ---
    Is that you, Killer T?
[16:10] ---
    I know you looked out
    for Naive the other day.
[16:15] ---
    Too bad for him.
[16:17] ---
    Did he get infected
    with a virus, maybe?
[16:19] ---
    That's what I thought.
[16:22] ---
    Hard to stomach, isn't it?
[16:24] ---
    Incidents involving
    your own friends.
[16:27] ---
    Now then,
[16:28] ---
    I'm gonna take this corpse
    into custody, all right?
[16:32] ---
    Excuse me.
[16:34] ---
    Dealing with cell-related trouble...
    That's our job!
[16:37] ---
    Your main job is to kill bacteria, right?
[16:42] ---
    It's not like we don't take care
    of cell-related trouble, too.
[16:46] ---
    Excuse me!
[16:50] ---
    Hey, what's the problem?
[16:52] ---
    I mean, I'm bored
    since no jobs have been coming in!
[16:58] ---
    You're...
[17:00] ---
    NK Cell!
SIGN    NK CELL (NATURAL KILLER CELL):
    They patrol the entire body,
    attacking as soon as they spot
    Cancer Cells or viruses.
[17:01] ---
    NK Cell.
[17:03] ---
    They patrol the entire body,
[17:05] ---
    attacking as soon as they spot
[17:08] ---
    Cancer Cells or viruses.
[17:10] ---
    Hey, my bad.
    I couldn't find a suitable cushion.
[17:14] ---
    Damn you! What do you want?
[17:16] ---
    I knew it.
[17:18] ---
    This guy's no ordinary virus.
[17:21] ---
    He's the type
    who proliferates at warp speed.
[17:24] ---
    I'm pretty sure
    his friends are still around, so...
[17:27] ---
    Maybe I'll ask that cell there
    to show me the way?
[17:31] ---
    Hey you,
[17:33] ---
    it's not just this one virus, right?
[17:37] ---
    Um, that's correct.
[17:38] ---
    There are still some in my area!
[17:40] ---
    What? In the cell system?
[17:42] ---
    Y-You should've spoken up sooner!
[17:44] ---
    Well, that's what I've been trying
    to tell you all this time.
[17:47] ---
    You damn idiot! Show us the way now!
[17:49] ---
    Hold up a second!
[17:51] ---
    As it happens, I've been extremely idle.
[17:54] ---
    Sorry, but I'm going to take this job!
[17:57] ---
    What?
[17:59] ---
    One more thing...
[18:00] ---
    I don't want you guys
    to come along.
[18:02] ---
    The last thing I need
    is to have you underfoot.
[18:05] ---
    So I'll be going off alone!
[18:06] ---
    Wh-Why, you, who do you think you—
[18:10] ---
    Oops, my hand slipped.
[18:12] ---
    Sorry!
[18:13] ---
    I'm powerful, so I'll be fine.
[18:16] ---
    Hey, Killer T. You all right?
[18:21] ---
    And then, you see...
[18:23] ---
    A bucket? Sure!
[18:31] ---
    Oops, my bad. My hand slipped.
[18:37] ---
    We wouldn't want you to catch a cold,
    so you go on home, young lady, and sit tight!
[18:42] ---
    Oops! My hand slipped again!
[18:44] ---
    Sorry! My foot slipped!
[18:46] ---
    I apologize! My elbow slipped!
[18:49] ---
    That's too much slipping!
    You going senile or what?
[18:53] ---
    Who are you to talk?
[18:56] ---
    I'm gonna kill you!
[18:57] ---
    Huh! I'd like to see you try it!
[19:00] ---
    They're allies,
    but they're killing each other!
[19:02] ---
    Just what you'd expect of immunity cells.
[19:04] ---
    Th-They sure don't get along.
[19:07] ---
    Yeah, they probably don't.
[19:09] ---
    Maybe we should just leave them behind.
[19:12] ---
    By the way, Cell...
[19:13] ---
    About showing us the way...
[19:15] ---
    You don't have to come
    the whole way, okay?
[19:18] ---
    The cells I'm going off to kill
    might have been your friends or neighbors.
[19:24] ---
    You wouldn't want to see that, do you?
[19:27] ---
    No, hey, I'll be fine!
[19:29] ---
    I'll take you all the way.
[19:31] ---
    Since it's for the sake of this world.
[19:34] ---
    And besides, remember?
    You just saved my life.
[19:39] ---
    Thank you very much.
[19:40] ---
    That was the first time
    I'd ever been rescued.
[19:44] ---
    Don't worry! I totally understand.
[19:47] ---
    That this is something
    we can't do anything about.
[19:50] ---
    That for the sake of world peace,
    sometimes your friends can get killed.
[19:55] ---
    And also the fact that that's your job.
[19:59] ---
    Is that right? I appreciate that.
[20:02] ---
    Anyway, who knew there were immunity cells
    who were sensitive to that?
[20:07] ---
    W-Well, maybe.
[20:10] ---
    Not that I can broadcast it
    in front of Killer T.
[20:14] ---
    I win!
[20:15] ---
    I haven't lost yet!
[20:19] ---
    CELL SYSTEM
[20:19] ---
    I thought that cells were living here...
[20:22] ---
    There's no sign of them.
[20:24] ---
    That virus's friends are probably laying low.
[20:29] ---
    Come on!
[20:33] ---
    It's deserted.
[20:36] ---
    This is serious.
[20:39] ---
    For now, let's report to HQ,
    and then we'll patrol the area together.
[20:43] ---
    Together? No way in hell is that happening!
[20:46] ---
    Then it'll be two against two!
[20:47] ---
    And I'm taking our guide with me!
[20:49] ---
    Sure, be my guest!
[20:51] ---
    It would be so uncool
    if the Lone Wolf got herself lost, huh?
[20:54] ---
    H-Hey, no fighting!
[20:56] ---
    I'm not fighting!
    This is a rejection reaction!
[20:59] ---
    No way can I focus on my work
    if I'm teamed up with someone like that!
[21:03] ---
    Oh thank goodness!
[21:05] ---
    Now I'm freed
    from babysitting the moron!
[21:11] ---
    Hey!
[21:12] ---
    Don't let your personal feelings
    get in the way!
[21:15] ---
    Come back here!
[21:16] ---
    It'll get worse if we go along with her!
[21:21] ---
    I'm talking about compatibility!
    Compatibility!
[21:26] ---
    You don't know when to shut up, do you?
[21:29] ---
    Now, then...
[21:32] ---
    We should get started, too, right?
[21:37] ---
    Since that pain in the neck
    is out of the way,
[21:40] ---
    I'll be glad to take you on,
    that's what I'm saying.
[21:43] ---
    Although if what you want is to die
    as someone else, feel free to stand pat.
[21:47] ---
    Show me who you really are!
[21:53] ---
    So, I'm busted, huh?
[23:24] ---
    NEXT EPISODE
    PREVIEW
[23:26] ---
    I'm getting a bad vibe.
[23:28] ---
    Come on, let me enjoy myself a little longer!
[23:30] ---
    This is no viral infection!
[23:32] ---
    You ripped me off!
[23:33] ---
    What happened to that cell kid?
[23:34] ---
    There's something strange going on!
[23:36] ---
    All three of you are here, I see.
[23:37] ---
    EPISODE 7:
    CANCER CELL