E6 - Kidneys, Kidney Stones, and Tears

Source: Crunchyroll
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(Please feel free to edit the speaker names if incomplete or inaccurate. Names are handled on a best-effort basis depending on the info on the source file. Dialogue is left as is.)
[00:04] ---
    Run!
[00:05] ---
    There's something in the urinary tract!
[00:10] ---
    The urine...
[00:13] ---
    is bright red with blood.
[00:17] ---
    I've never seen anything this massive.
[00:21] ---
    What should we do?
[00:23] ---
    There's nothing...
[00:25] ---
    that we can do!
[02:03] ---
    EPISODE 6:
    KIDNEYS, KIDNEY STONES, AND TEARS
[02:07] ---
    Yo! Good work!
[02:08] ---
    Where are you heading back from?
[02:10] ---
    The small intestine.
    They just yelled at me to bring more oxygen.
[02:14] ---
    Seems like nobody has enough.
[02:16] ---
    Oh well, let's do our part
    and deliver as much as we can.
[02:24] ---
    What's going on here?
[02:26] ---
    The waste is all backed up
    because of dehydration.
[02:30] ---
    We're seeing more and more
    of these blood vessels lately, huh—
[02:34] ---
    Whoa! Whoa! Whoa!
[02:39] ---
    Are you okay?
[02:44] ---
    I could've fallen!
    Hey, what do you think you're doing?
[02:47] ---
    Well, I don't want to be
    the only one getting dirty!
[02:49] ---
    Stay away from me! Whoa!
[02:54] ---
    Oh man! Come on!
    Stop fooling around!
[02:57] ---
    Your face is a mess.
[03:00] ---
    So is yours.
[03:07] ---
    Jeez, thanks to you, I'm sticky all over.
    It feels disgusting!
[03:12] ---
    My bad!
[03:13] ---
    But the kidneys
    aren't too far from here, right?
[03:16] ---
    Let's go get cleaned up.
[03:18] ---
    Hey, good idea!
[03:21] ---
    NEPHRON
[03:24] ---
    This is it!
[03:26] ---
    The liver's a fun place, too, but the Glomeruli here
    have a kind of grace. That's what I like about it!
[03:34] ---
    TALKING IS STRICTLY FORBIDDEN
[03:35] ---
    Thanks for looking after me today, Glomerulus.
[03:39] ---
    The Glomeruli.
[03:41] ---
    Their job is to filter the blood.
[03:47] ---
    Hello there! Here I am again!
    Take good care of me today, okay?
[03:51] ---
    How have you been?
    I'm grungier than usual today, huh?
[03:56] ---
    I suppose so.
[03:57] ---
    Yeah, but wouldn't you say
    that's the measure of a working man?
[04:00] ---
    Thank you so much
    for all your hard work.
[04:02] ---
    Hey, you there!
[04:04] ---
    You need to move your hands,
    not your mouth!
[04:09] ---
    TALKING IS STRICTLY FORBIDDEN
[04:10] ---
    Uh, sorry about that.
[04:15] ---
    The kidneys.
[04:17] ---
    Organs made up of approximately
    one million nephrons,
[04:20] ---
    each of which are comprised
    of renal tubules attached to Glomeruli...
[04:24] ---
    which filter the blood.
[04:27] ---
    Urine is the by-product
    of this filtering process.
[04:32] ---
    Hey, hey! I'm still not clean!
    Do a better job of washing it off!
[04:37] ---
    I'm so sorry.
[04:38] ---
    For heaven's sake, we're the ones
    running around all day, and we're exhausted!
[04:42] ---
    Unlike you people who do nothing
    but stand around like statues!
[04:47] ---
    That's no way to talk.
[04:50] ---
    We're used to it.
[04:52] ---
    It's fine.
[04:58] ---
    Well, I appreciate it.
[05:01] ---
    All that you Glomeruli do for us...
[05:04] ---
    24/7, 365 days a year...
[05:07] ---
    you keep filtering the blood for us.
[05:10] ---
    It's thanks to you that we can
    deliver oxygen in a clean state.
[05:18] ---
    Not to mention, the blood's been all gooey lately,
    so I'm sure you've been busy.
[05:24] ---
    Overeating... Overdrinking...
[05:28] ---
    This body's blood vessels are so clogged up,
[05:31] ---
    it's only a matter of time
    before something happens.
[05:34] ---
    On top of that,
    there's been a rise in oxalic acid lately...
[05:39] ---
    because of that... Th-The... You know—
[05:41] ---
    Hey you!
[05:42] ---
    What are you doing,
    prattling on and on like that?
[05:45] ---
    I'm sorry!
[05:46] ---
    Enough with the idle chatter!
    Get to work!
[05:49] ---
    Right.
[05:50] ---
    I'm so sorry.
    It's my fault for talking so much.
[05:54] ---
    Um...
[05:56] ---
    Please be careful when you pass by the ureter.
[06:00] ---
    The ureter?
[06:04] ---
    Oh boy! Talk about refreshing!
[06:07] ---
    Wanna go again
    after we're done with this round?
[06:09] ---
    I don't think we should rely
    on the Glomeruli too much.
[06:13] ---
    You saw how they were working
    so hard in silence.
[06:15] ---
    You're no fun! What a straight arrow!
[06:22] ---
    Do you hear that weird sound?
[06:24] ---
    Huh?
[06:25] ---
    This is near the ureter, right?
[06:28] ---
    Isn't this where the urine
    that the kidneys just produced comes through?
[06:32] ---
    No. It sounds like something's stuck.
[06:36] ---
    Please be careful when you pass by the ureter.
[06:45] ---
    The wall!
[06:51] ---
    Wh-What the cell are those?
[06:56] ---
    The ureter's been ruptured!
[06:57] ---
    The foreign object is still lodged inside!
[06:59] ---
    Not looking good for spontaneous passage!
[07:02] ---
    A one-centimeter stone?
[07:04] ---
    How are we supposed to deal with that?
[07:07] ---
    Kidney stones.
[07:08] ---
    The most common types of kidney stones
    are calcium oxalate stones,
[07:14] ---
    formed when the oxalic acid and calcium in the
    waste filtered by kidneys crystalize in the urine.
[07:20] ---
    Stones that are larger than one centimeter
    are harder to pass naturally.
[07:29] ---
    The tear in the ureter is spreading!
[07:31] ---
    Everybody, run! Please run!
[07:38] ---
    It's going to start bleeding!
[07:45] ---
    Gross hematuria.
[07:47] ---
    When massive amounts
    of Red Blood Cells enter the urine
[07:50] ---
    until it can be perceived as red
    by the naked eye.
[07:52] ---
    When it's negligible and doesn't appear red
    to the naked eye,
[07:56] ---
    it's called "microscopic hematuria"
    or "uric blood."
[08:00] ---
    This is messed up!
[08:01] ---
    If we don't get out of here,
    we'll end up getting swept away, too!
[08:04] ---
    Acute pain has been triggered!
[08:06] ---
    Both the heart rate
    and blood pressure are rising!
[08:09] ---
    Kidney stones are sometimes accompanied
    by pain so severe,
[08:13] ---
    they're known as the "King of Pain."
[08:16] ---
    The kidney's internal pressure is rising!
[08:18] ---
    It's now affecting the cellular structure!
[08:27] ---
    Gran—
[08:28] ---
    Not another word out of you!
[08:30] ---
    Listen to me. These kidneys
    are known as "silent organs."
[08:34] ---
    Whatever happens,
    whining has no place here!
[08:36] ---
    We've got to go on working in silence!
[08:39] ---
    Even if the kidneys start to malfunction,
    symptoms are often hard to detect.
[08:45] ---
    Hence they're known as "silent organs."
[08:56] ---
    Are you all right?
[08:57] ---
    Yeah.
[09:06] ---
    It stopped.
[09:10] ---
    Hey, what are you doing?
[09:12] ---
    If it stays stuck in here,
    the pain's only going to spread!
[09:17] ---
    We have to get rid of this,
    for the Glomeruli's sake, too!
[09:22] ---
    Huh? If that thing starts moving,
[09:24] ---
    it could rip through the ureter again,
    and then, we'd end up in the urine!
[09:31] ---
    There it is again. You're so predictable.
[09:38] ---
    Ah, all right.
[09:43] ---
    - Wh-What's this?
    - What's going on?
[09:45] ---
    Something just entered via the urethra!
[09:48] ---
    What?
[09:51] ---
    URINE
[09:51] ---
    And now, it's blowing past the bladder, wrenching
    open the check valve and entering the ureter!
[09:56] ---
    It's reached the kidney stone!
[10:07] ---
    What's this? What's this sound?
    Is it coming from inside the ureter?
[10:13] ---
    Wh-What the cell?
[10:18] ---
    Transurethral ureteroscopic lithotripsy.
[10:21] ---
    A surgical method for smashing kidney stones with
    lasers by inserting an endoscope into the urethra.
[10:27] ---
    It's all crushed up.
[10:32] ---
    Th-The fragments of the stone
    are flowing away!
[10:35] ---
    - Are you all right?
    - Hey...
[10:37] ---
    WHITE BLOOD CELL
[10:38] ---
    White Blood Cell! So, you came to help?
[10:42] ---
    You couldn't look more thrilled, rookie.
[10:44] ---
    And we're not even on your radar!
[10:47] ---
    Oh, hey, no, I didn't mean to...
[10:50] ---
    There's no time for idle chatter.
    We're taking you to a place that escaped damage.
[10:54] ---
    Okay!
[10:56] ---
    Platelets, we're leaving the rest to you!
[10:58] ---
    Sure thing! Let us handle this!
[10:58] ---
    PLATELETS
[11:01] ---
    There won't be any more stones
    coming this way, right?
[11:03] ---
    Like a really huge one?
[11:06] ---
    If something like that happened,
    we'd end up in the urine, too.
[11:08] ---
    Who cares?
    If it happens, it happens!
[11:11] ---
    Just get to work so that it doesn't happen!
[11:14] ---
    Okay.
[11:16] ---
    The Platelets are having a tough time, too.
[11:23] ---
    White Blood Cell,
    are you good to work now?
[11:26] ---
    I think I'm in even better shape than before.
[11:29] ---
    Really?
[11:30] ---
    Well, that thing that was stuck in the ureter
    got smashed up and washed away,
[11:33] ---
    so I guess it's all good now.
[11:36] ---
    But it's still too early to relax.
[11:39] ---
    Huh?
[11:40] ---
    That's right.
[11:41] ---
    If we White Blood Cells
    are gathered in one spot...
[11:46] ---
    That means that something's been detected.
[11:56] ---
    If we make our way back
    through this tube,
[11:59] ---
    we can go all the way in!
[12:03] ---
    Germs are heading this way
    through the urethra?
[12:05] ---
    Yes. They're using the tube that was inserted
    into this body to make their way in.
[12:10] ---
    Meaning that they're on their way
    to where the Glomeruli are.
[12:15] ---
    The kidneys.
[12:18] ---
    The bacteria has invaded
    the bladder via the tube!
[12:22] ---
    How can this be happening?
[12:24] ---
    Normally, the check valve
    would protect it,
[12:27] ---
    making it hard for external bacteria
    to reenter from the urethra.
[12:32] ---
    Yes, but right now the tube that smashed
    that kidney stone is inserted into the ureter,
[12:37] ---
    so the bacteria can use it
    to infiltrate all the way in.
[12:41] ---
    Is such a thing even possible?
[12:43] ---
    To our knowledge, it would only happen
    in extremely rare cases.
[12:47] ---
    So, this body's been abandoned
    by luck, even?
[12:50] ---
    At this time, the bacteria have reached
    the bladder. If they breach the ureter...
[12:56] ---
    it could cause acute pyelonephritis!
[12:59] ---
    Acute pyelonephritis.
[13:02] ---
    An infection of the renal pelvis
    where the kidneys store urine,
[13:05] ---
    triggered by a backflow of bacteria
    from the urine.
[13:10] ---
    Unless treated properly,
[13:13] ---
    the bacteria can invade
    the bloodstream or even cause sepsis.
[13:18] ---
    If the germs climb all the way up here...
[13:25] ---
    They're here.
[13:26] ---
    Huh?
[13:30] ---
    Whoa! Are you kidding me?
[13:32] ---
    You two get away from here.
[13:37] ---
    Let's go.
[13:41] ---
    Everyone, attack mode.
[13:44] ---
    We can't let them get past us!
[13:48] ---
    Whatever it takes, annihilate them!
[13:50] ---
    Charge!
[13:55] ---
    Hey, where are you going?
[13:57] ---
    To the kidney!
[13:58] ---
    Huh? Why would you go there?
[14:01] ---
    Those germs are heading toward the kidney!
    Didn't you hear White Blood Cell—
[14:05] ---
    That's why we're going!
[14:06] ---
    Hey, are you serious?
[14:09] ---
    Hey! Wait up, will you!
[14:16] ---
    Hey, you're on a roll!
[14:18] ---
    Well, I haven't fought in a while,
    so I'm bursting with all this extra energy.
[14:22] ---
    Still...
[14:23] ---
    talk about outnumbered!
[14:26] ---
    Well, we did get decimated
    in that gonococci battle.
[14:30] ---
    The White Blood Cells are struggling!
[14:32] ---
    At this rate, it's only a matter of time
    before the kidney's breached!
[14:35] ---
    Did you call on the Macrophages for backup?
[14:37] ---
    I did. However...
[14:40] ---
    it will be a while before they get there.
[14:43] ---
    Macrophages.
[14:45] ---
    They advance at a slower speed
    than White Blood Cells.
[14:49] ---
    If worst comes to worst,
    we'll have to abandon the kidney.
[14:53] ---
    What?
[14:55] ---
    The body has two kidneys.
[14:57] ---
    Even if one is lost...
[14:58] ---
    the body can still survive.
[15:01] ---
    If that were to happen...
[15:03] ---
    what would become of the Glomeruli
    who work in the abandoned kidney?
[15:06] ---
    I said it was the worst case scenario!
[15:09] ---
    Hang in there to ensure
    it doesn't end up that way, White Blood Cells!
[15:24] ---
    Pyuria.
[15:25] ---
    When bacteria invades the urinary tract,
    triggering inflammation,
[15:29] ---
    leading to White Blood Cells permeating the urine
    which gives it a cloudy appearance.
[15:35] ---
    We don't have
    enough White Blood Cells as it is!
[15:40] ---
    Everybody!
[15:41] ---
    The germs are closing in!
[15:43] ---
    Hide!
[15:46] ---
    Not happening! Get back to work!
[15:48] ---
    Gran...
[15:50] ---
    It's an emergency!
    This is no time to be talking like—
[15:53] ---
    This is a silent organ.
[15:56] ---
    We've got to go on working in silence
    no matter what!
[16:03] ---
    Please...
[16:04] ---
    don't push them any harder
    than you already are.
[16:08] ---
    Just let them...
[16:10] ---
    Just let them complain a little now and then!
[16:13] ---
    Listen to what they have to say!
[16:20] ---
    You're really overstepping.
[16:21] ---
    What?
[16:22] ---
    We have our own way of doing things.
[16:25] ---
    I'll thank you not to butt in!
[16:29] ---
    She's right.
    This has nothing to do with us.
[16:32] ---
    Come on, let's go.
[16:34] ---
    I-If I may, Gran...
[16:39] ---
    It's true that you're strict, Gran,
    but you taught us everything about our work,
[16:45] ---
    so we're all very grateful to you.
[16:47] ---
    And we do understand
    that you're strict with us because you care.
[16:54] ---
    So, we have no intention
    of complaining or whining.
[16:58] ---
    Even so...
[17:00] ---
    Even so...
[17:03] ---
    there are times
    when we want to just cry!
[17:12] ---
    The germs got this far?
[17:20] ---
    Look out!
[17:28] ---
    Gran?
[17:40] ---
    White Blood Cell!
[17:46] ---
    I couldn't hold them back in the ureter.
[17:50] ---
    But I won't let them
    get any farther than this.
[17:55] ---
    Gran! Gran!
[17:58] ---
    Gran, I'm so sorry.
    If it wasn't... If it wasn't for me...
[18:04] ---
    Are you okay?
[18:05] ---
    But why?
[18:07] ---
    Forgive me for always giving you all
    such a hard time.
[18:14] ---
    At least, I got to make up for it
    in the end. Thank goodness.
[18:18] ---
    Don't talk like this is the end! Gran!
[18:21] ---
    I want you to keep on teaching us
    all about the kidneys!
[18:27] ---
    Gran!
[18:31] ---
    Wh-What is it, Gran?
[18:35] ---
    Get to work.
[18:39] ---
    You're still Kidney Cells.
[18:43] ---
    It's up to the rest of you
    who are left to get it done.
[18:48] ---
    Humans are born
    with approximately two million Glomeruli...
[18:53] ---
    but these numbers gradually dwindle, as once
    damaged, the Glomeruli can't regenerate.
[18:59] ---
    Unless we keep working, this body
    will soon be riddled with waste products.
[19:07] ---
    We're a silent organ.
[19:12] ---
    Get to work... in silence.
[19:15] ---
    You have to... work.
[19:32] ---
    Thank you!
[19:34] ---
    Still...
[19:36] ---
    Yeah.
[19:37] ---
    No matter how many of them we slash,
    more and more keep popping up!
[19:44] ---
    What's that?
[19:47] ---
    Target identified. Now disinfecting.
[19:54] ---
    New quinolone antibacterial drug.
[19:57] ---
    Drugs that act as bactericides
    by inhibiting DNA gyrase activity.
[20:03] ---
    Effective against urinary, intestinal
    and respiratory infections.
[20:11] ---
    The antibiotics have arrived!
[20:13] ---
    Looks like the cells will be able to hold on!
[20:15] ---
    Is that right?
[20:22] ---
    If we keep barely coming out on top
    in these battles, one of these days...
[20:34] ---
    Come this way, please.
[20:35] ---
    - Huh?
    - Huh?
[20:37] ---
    Please wash off all those
    waste products and freshen up.
[20:44] ---
    We're going to go all around the body now.
[20:48] ---
    But look how soiled you are.
    You shouldn't.
[20:51] ---
    We'll be totally fine
    for just one round, right?
[20:53] ---
    Huh?
[20:54] ---
    - Let's go.
    - Uh, yeah, I guess.
[21:02] ---
    Even if it's just for a split second,
[21:04] ---
    go ahead and cry your eyes out.
[21:06] ---
    For your Gran's sake, too.
[21:09] ---
    Huh! Acting so cool...
[21:12] ---
    That's not what that was about.
[21:15] ---
    Once again, it really hit home.
[21:22] ---
    That even if you're suffering,
[21:24] ---
    and let yourself complain about it,
[21:26] ---
    there's nothing you can do.
[21:27] ---
    That's what a code black environment is.
[21:32] ---
    Even so...
[21:34] ---
    I...
[21:40] ---
    I'm feeling that power surge!
[21:42] ---
    Awesome! Who knew that there was
    still a heaven in this world?
[21:46] ---
    This totally rocks!
[23:19] ---
    PREVIEW
[23:20] ---
    Here it comes!
    I can feel it surging!
[23:22] ---
    CAFFEINE
[23:24] ---
    This is manna from heaven.
[23:25] ---
    TEMPTATION
[23:27] ---
    Even if I'm right next to him...
[23:28] ---
    JEALOUSY
[23:29] ---
    all I ever do is try to run away.
[23:31] ---
    CAFFEINE, TEMPTATION, AND JEALOUSY