# E6 - Kidneys, Kidney Stones, and Tears
Source: [Crunchyroll](https://www.crunchyroll.com/watch/GZ7UV782V/kidneys-kidney-stones-and-tears)
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(Please feel free to edit the speaker names if incomplete or inaccurate. Names are handled on a best-effort basis depending on the info on the source file. Dialogue is left as is.)
**[00:04] ---**
Run!
**[00:05] ---**
There's something in the urinary tract!
**[00:10] ---**
The urine...
**[00:13] ---**
is bright red with blood.
**[00:17] ---**
I've never seen anything this massive.
**[00:21] ---**
What should we do?
**[00:23] ---**
There's nothing...
**[00:25] ---**
that we can do!
**[02:03] ---**
EPISODE 6:
KIDNEYS, KIDNEY STONES, AND TEARS
**[02:07] ---**
Yo! Good work!
**[02:08] ---**
Where are you heading back from?
**[02:10] ---**
The small intestine.
They just yelled at me to bring more oxygen.
**[02:14] ---**
Seems like nobody has enough.
**[02:16] ---**
Oh well, let's do our part
and deliver as much as we can.
**[02:24] ---**
What's going on here?
**[02:26] ---**
The waste is all backed up
because of dehydration.
**[02:30] ---**
We're seeing more and more
of these blood vessels lately, huh—
**[02:34] ---**
Whoa! Whoa! Whoa!
**[02:39] ---**
Are you okay?
**[02:44] ---**
I could've fallen!
Hey, what do you think you're doing?
**[02:47] ---**
Well, I don't want to be
the only one getting dirty!
**[02:49] ---**
Stay away from me! Whoa!
**[02:54] ---**
Oh man! Come on!
Stop fooling around!
**[02:57] ---**
Your face is a mess.
**[03:00] ---**
So is yours.
**[03:07] ---**
Jeez, thanks to you, I'm sticky all over.
It feels disgusting!
**[03:12] ---**
My bad!
**[03:13] ---**
But the kidneys
aren't too far from here, right?
**[03:16] ---**
Let's go get cleaned up.
**[03:18] ---**
Hey, good idea!
**[03:21] ---**
NEPHRON
**[03:24] ---**
This is it!
**[03:26] ---**
The liver's a fun place, too, but the Glomeruli here
have a kind of grace. That's what I like about it!
**[03:34] ---**
TALKING IS STRICTLY FORBIDDEN
**[03:35] ---**
Thanks for looking after me today, Glomerulus.
**[03:39] ---**
*The Glomeruli.*
**[03:41] ---**
*Their job is to filter the blood.*
**[03:47] ---**
Hello there! Here I am again!
Take good care of me today, okay?
**[03:51] ---**
How have you been?
I'm grungier than usual today, huh?
**[03:56] ---**
I suppose so.
**[03:57] ---**
Yeah, but wouldn't you say
that's the measure of a working man?
**[04:00] ---**
Thank you so much
for all your hard work.
**[04:02] ---**
Hey, you there!
**[04:04] ---**
You need to move your hands,
not your mouth!
**[04:09] ---**
TALKING IS STRICTLY FORBIDDEN
**[04:10] ---**
Uh, sorry about that.
**[04:15] ---**
*The kidneys.*
**[04:17] ---**
*Organs made up of approximately
one million nephrons,*
**[04:20] ---**
*each of which are comprised
of renal tubules attached to Glomeruli...*
**[04:24] ---**
*which filter the blood.*
**[04:27] ---**
*Urine is the by-product
of this filtering process.*
**[04:32] ---**
Hey, hey! I'm still not clean!
Do a better job of washing it off!
**[04:37] ---**
I'm so sorry.
**[04:38] ---**
For heaven's sake, we're the ones
running around all day, and we're exhausted!
**[04:42] ---**
Unlike you people who do nothing
but stand around like statues!
**[04:47] ---**
That's no way to talk.
**[04:50] ---**
We're used to it.
**[04:52] ---**
It's fine.
**[04:58] ---**
Well, I appreciate it.
**[05:01] ---**
All that you Glomeruli do for us...
**[05:04] ---**
24/7, 365 days a year...
**[05:07] ---**
you keep filtering the blood for us.
**[05:10] ---**
It's thanks to you that we can
deliver oxygen in a clean state.
**[05:18] ---**
Not to mention, the blood's been all gooey lately,
so I'm sure you've been busy.
**[05:24] ---**
Overeating... Overdrinking...
**[05:28] ---**
This body's blood vessels are so clogged up,
**[05:31] ---**
it's only a matter of time
before something happens.
**[05:34] ---**
On top of that,
there's been a rise in oxalic acid lately...
**[05:39] ---**
because of that... Th-The... You know—
**[05:41] ---**
Hey you!
**[05:42] ---**
What are you doing,
prattling on and on like that?
**[05:45] ---**
I'm sorry!
**[05:46] ---**
Enough with the idle chatter!
Get to work!
**[05:49] ---**
Right.
**[05:50] ---**
I'm so sorry.
It's my fault for talking so much.
**[05:54] ---**
Um...
**[05:56] ---**
Please be careful when you pass by the ureter.
**[06:00] ---**
The ureter?
**[06:04] ---**
Oh boy! Talk about refreshing!
**[06:07] ---**
Wanna go again
after we're done with this round?
**[06:09] ---**
I don't think we should rely
on the Glomeruli too much.
**[06:13] ---**
You saw how they were working
so hard in silence.
**[06:15] ---**
You're no fun! What a straight arrow!
**[06:22] ---**
Do you hear that weird sound?
**[06:24] ---**
Huh?
**[06:25] ---**
This is near the ureter, right?
**[06:28] ---**
Isn't this where the urine
that the kidneys just produced comes through?
**[06:32] ---**
No. It sounds like something's stuck.
**[06:36] ---**
*Please be careful when you pass by the ureter.*
**[06:45] ---**
The wall!
**[06:51] ---**
Wh-What the cell are those?
**[06:56] ---**
The ureter's been ruptured!
**[06:57] ---**
The foreign object is still lodged inside!
**[06:59] ---**
Not looking good for spontaneous passage!
**[07:02] ---**
A one-centimeter stone?
**[07:04] ---**
How are we supposed to deal with that?
**[07:07] ---**
*Kidney stones.*
**[07:08] ---**
*The most common types of kidney stones
are calcium oxalate stones,*
**[07:14] ---**
*formed when the oxalic acid and calcium in the
waste filtered by kidneys crystalize in the urine.*
**[07:20] ---**
*Stones that are larger than one centimeter
are harder to pass naturally.*
**[07:29] ---**
The tear in the ureter is spreading!
**[07:31] ---**
Everybody, run! Please run!
**[07:38] ---**
It's going to start bleeding!
**[07:45] ---**
*Gross hematuria.*
**[07:47] ---**
*When massive amounts
of Red Blood Cells enter the urine*
**[07:50] ---**
*until it can be perceived as red
by the naked eye.*
**[07:52] ---**
*When it's negligible and doesn't appear red
to the naked eye,*
**[07:56] ---**
*it's called "microscopic hematuria"
or "uric blood."*
**[08:00] ---**
This is messed up!
**[08:01] ---**
If we don't get out of here,
we'll end up getting swept away, too!
**[08:04] ---**
Acute pain has been triggered!
**[08:06] ---**
Both the heart rate
and blood pressure are rising!
**[08:09] ---**
*Kidney stones are sometimes accompanied
by pain so severe,*
**[08:13] ---**
*they're known as the "King of Pain."*
**[08:16] ---**
The kidney's internal pressure is rising!
**[08:18] ---**
It's now affecting the cellular structure!
**[08:27] ---**
Gran—
**[08:28] ---**
Not another word out of you!
**[08:30] ---**
Listen to me. These kidneys
are known as "silent organs."
**[08:34] ---**
Whatever happens,
whining has no place here!
**[08:36] ---**
We've got to go on working in silence!
**[08:39] ---**
*Even if the kidneys start to malfunction,
symptoms are often hard to detect.*
**[08:45] ---**
*Hence they're known as "silent organs."*
**[08:56] ---**
Are you all right?
**[08:57] ---**
Yeah.
**[09:06] ---**
It stopped.
**[09:10] ---**
Hey, what are you doing?
**[09:12] ---**
If it stays stuck in here,
the pain's only going to spread!
**[09:17] ---**
We have to get rid of this,
for the Glomeruli's sake, too!
**[09:22] ---**
Huh? If that thing starts moving,
**[09:24] ---**
it could rip through the ureter again,
and then, we'd end up in the urine!
**[09:31] ---**
There it is again. You're so predictable.
**[09:38] ---**
Ah, all right.
**[09:43] ---**
- Wh-What's this?
- What's going on?
**[09:45] ---**
Something just entered via the urethra!
**[09:48] ---**
What?
**[09:51] ---**
URINE
**[09:51] ---**
And now, it's blowing past the bladder, wrenching
open the check valve and entering the ureter!
**[09:56] ---**
It's reached the kidney stone!
**[10:07] ---**
What's this? What's this sound?
Is it coming from inside the ureter?
**[10:13] ---**
Wh-What the cell?
**[10:18] ---**
*Transurethral ureteroscopic lithotripsy.*
**[10:21] ---**
*A surgical method for smashing kidney stones with
lasers by inserting an endoscope into the urethra.*
**[10:27] ---**
It's all crushed up.
**[10:32] ---**
Th-The fragments of the stone
are flowing away!
**[10:35] ---**
- Are you all right?
- Hey...
**[10:37] ---**
WHITE BLOOD CELL
**[10:38] ---**
White Blood Cell! So, you came to help?
**[10:42] ---**
You couldn't look more thrilled, rookie.
**[10:44] ---**
And we're not even on your radar!
**[10:47] ---**
Oh, hey, no, I didn't mean to...
**[10:50] ---**
There's no time for idle chatter.
We're taking you to a place that escaped damage.
**[10:54] ---**
Okay!
**[10:56] ---**
Platelets, we're leaving the rest to you!
**[10:58] ---**
Sure thing! Let us handle this!
**[10:58] ---**
PLATELETS
**[11:01] ---**
There won't be any more stones
coming this way, right?
**[11:03] ---**
Like a really huge one?
**[11:06] ---**
If something like that happened,
we'd end up in the urine, too.
**[11:08] ---**
Who cares?
If it happens, it happens!
**[11:11] ---**
Just get to work so that it doesn't happen!
**[11:14] ---**
Okay.
**[11:16] ---**
The Platelets are having a tough time, too.
**[11:23] ---**
White Blood Cell,
are you good to work now?
**[11:26] ---**
I think I'm in even better shape than before.
**[11:29] ---**
Really?
**[11:30] ---**
Well, that thing that was stuck in the ureter
got smashed up and washed away,
**[11:33] ---**
so I guess it's all good now.
**[11:36] ---**
But it's still too early to relax.
**[11:39] ---**
Huh?
**[11:40] ---**
That's right.
**[11:41] ---**
If we White Blood Cells
are gathered in one spot...
**[11:46] ---**
That means that something's been detected.
**[11:56] ---**
If we make our way back
through this tube,
**[11:59] ---**
we can go all the way in!
**[12:03] ---**
Germs are heading this way
through the urethra?
**[12:05] ---**
Yes. They're using the tube that was inserted
into this body to make their way in.
**[12:10] ---**
Meaning that they're on their way
to where the Glomeruli are.
**[12:15] ---**
The kidneys.
**[12:18] ---**
The bacteria has invaded
the bladder via the tube!
**[12:22] ---**
How can this be happening?
**[12:24] ---**
Normally, the check valve
would protect it,
**[12:27] ---**
making it hard for external bacteria
to reenter from the urethra.
**[12:32] ---**
Yes, but right now the tube that smashed
that kidney stone is inserted into the ureter,
**[12:37] ---**
so the bacteria can use it
to infiltrate all the way in.
**[12:41] ---**
Is such a thing even possible?
**[12:43] ---**
To our knowledge, it would only happen
in extremely rare cases.
**[12:47] ---**
So, this body's been abandoned
by luck, even?
**[12:50] ---**
At this time, the bacteria have reached
the bladder. If they breach the ureter...
**[12:56] ---**
it could cause acute pyelonephritis!
**[12:59] ---**
*Acute pyelonephritis.*
**[13:02] ---**
*An infection of the renal pelvis
where the kidneys store urine,*
**[13:05] ---**
*triggered by a backflow of bacteria
from the urine.*
**[13:10] ---**
*Unless treated properly,*
**[13:13] ---**
*the bacteria can invade
the bloodstream or even cause sepsis.*
**[13:18] ---**
If the germs climb all the way up here...
**[13:25] ---**
They're here.
**[13:26] ---**
Huh?
**[13:30] ---**
Whoa! Are you kidding me?
**[13:32] ---**
You two get away from here.
**[13:37] ---**
Let's go.
**[13:41] ---**
Everyone, attack mode.
**[13:44] ---**
We can't let them get past us!
**[13:48] ---**
Whatever it takes, annihilate them!
**[13:50] ---**
Charge!
**[13:55] ---**
Hey, where are you going?
**[13:57] ---**
To the kidney!
**[13:58] ---**
Huh? Why would you go there?
**[14:01] ---**
Those germs are heading toward the kidney!
Didn't you hear White Blood Cell—
**[14:05] ---**
That's why we're going!
**[14:06] ---**
Hey, are you serious?
**[14:09] ---**
Hey! Wait up, will you!
**[14:16] ---**
Hey, you're on a roll!
**[14:18] ---**
Well, I haven't fought in a while,
so I'm bursting with all this extra energy.
**[14:22] ---**
Still...
**[14:23] ---**
talk about outnumbered!
**[14:26] ---**
Well, we did get decimated
in that gonococci battle.
**[14:30] ---**
The White Blood Cells are struggling!
**[14:32] ---**
At this rate, it's only a matter of time
before the kidney's breached!
**[14:35] ---**
Did you call on the Macrophages for backup?
**[14:37] ---**
I did. However...
**[14:40] ---**
it will be a while before they get there.
**[14:43] ---**
*Macrophages.*
**[14:45] ---**
*They advance at a slower speed
than White Blood Cells.*
**[14:49] ---**
If worst comes to worst,
we'll have to abandon the kidney.
**[14:53] ---**
What?
**[14:55] ---**
The body has two kidneys.
**[14:57] ---**
Even if one is lost...
**[14:58] ---**
the body can still survive.
**[15:01] ---**
If that were to happen...
**[15:03] ---**
what would become of the Glomeruli
who work in the abandoned kidney?
**[15:06] ---**
I said it was the worst case scenario!
**[15:09] ---**
Hang in there to ensure
it doesn't end up that way, White Blood Cells!
**[15:24] ---**
*Pyuria.*
**[15:25] ---**
*When bacteria invades the urinary tract,
triggering inflammation,*
**[15:29] ---**
*leading to White Blood Cells permeating the urine
which gives it a cloudy appearance.*
**[15:35] ---**
We don't have
enough White Blood Cells as it is!
**[15:40] ---**
Everybody!
**[15:41] ---**
The germs are closing in!
**[15:43] ---**
Hide!
**[15:46] ---**
Not happening! Get back to work!
**[15:48] ---**
Gran...
**[15:50] ---**
It's an emergency!
This is no time to be talking like—
**[15:53] ---**
This is a silent organ.
**[15:56] ---**
We've got to go on working in silence
no matter what!
**[16:03] ---**
Please...
**[16:04] ---**
don't push them any harder
than you already are.
**[16:08] ---**
Just let them...
**[16:10] ---**
Just let them complain a little now and then!
**[16:13] ---**
Listen to what they have to say!
**[16:20] ---**
You're really overstepping.
**[16:21] ---**
What?
**[16:22] ---**
We have our own way of doing things.
**[16:25] ---**
I'll thank you not to butt in!
**[16:29] ---**
She's right.
This has nothing to do with us.
**[16:32] ---**
Come on, let's go.
**[16:34] ---**
I-If I may, Gran...
**[16:39] ---**
It's true that you're strict, Gran,
but you taught us everything about our work,
**[16:45] ---**
so we're all very grateful to you.
**[16:47] ---**
And we do understand
that you're strict with us because you care.
**[16:54] ---**
So, we have no intention
of complaining or whining.
**[16:58] ---**
Even so...
**[17:00] ---**
Even so...
**[17:03] ---**
there are times
when we want to just cry!
**[17:12] ---**
The germs got this far?
**[17:20] ---**
Look out!
**[17:28] ---**
Gran?
**[17:40] ---**
White Blood Cell!
**[17:46] ---**
I couldn't hold them back in the ureter.
**[17:50] ---**
But I won't let them
get any farther than this.
**[17:55] ---**
Gran! Gran!
**[17:58] ---**
Gran, I'm so sorry.
If it wasn't... If it wasn't for me...
**[18:04] ---**
Are you okay?
**[18:05] ---**
But why?
**[18:07] ---**
Forgive me for always giving you all
such a hard time.
**[18:14] ---**
At least, I got to make up for it
in the end. Thank goodness.
**[18:18] ---**
Don't talk like this is the end! Gran!
**[18:21] ---**
I want you to keep on teaching us
all about the kidneys!
**[18:27] ---**
Gran!
**[18:31] ---**
Wh-What is it, Gran?
**[18:35] ---**
Get to work.
**[18:39] ---**
You're still Kidney Cells.
**[18:43] ---**
It's up to the rest of you
who are left to get it done.
**[18:48] ---**
*Humans are born
with approximately two million Glomeruli...*
**[18:53] ---**
*but these numbers gradually dwindle, as once
damaged, the Glomeruli can't regenerate.*
**[18:59] ---**
Unless we keep working, this body
will soon be riddled with waste products.
**[19:07] ---**
We're a silent organ.
**[19:12] ---**
Get to work... in silence.
**[19:15] ---**
You have to... work.
**[19:32] ---**
Thank you!
**[19:34] ---**
Still...
**[19:36] ---**
Yeah.
**[19:37] ---**
No matter how many of them we slash,
more and more keep popping up!
**[19:44] ---**
What's that?
**[19:47] ---**
*Target identified. Now disinfecting.*
**[19:54] ---**
*New quinolone antibacterial drug.*
**[19:57] ---**
*Drugs that act as bactericides
by inhibiting DNA gyrase activity.*
**[20:03] ---**
*Effective against urinary, intestinal
and respiratory infections.*
**[20:11] ---**
The antibiotics have arrived!
**[20:13] ---**
Looks like the cells will be able to hold on!
**[20:15] ---**
Is that right?
**[20:22] ---**
*If we keep barely coming out on top
in these battles, one of these days...*
**[20:34] ---**
Come this way, please.
**[20:35] ---**
- Huh?
- Huh?
**[20:37] ---**
Please wash off all those
waste products and freshen up.
**[20:44] ---**
We're going to go all around the body now.
**[20:48] ---**
But look how soiled you are.
You shouldn't.
**[20:51] ---**
We'll be totally fine
for just one round, right?
**[20:53] ---**
Huh?
**[20:54] ---**
- Let's go.
- Uh, yeah, I guess.
**[21:02] ---**
Even if it's just for a split second,
**[21:04] ---**
go ahead and cry your eyes out.
**[21:06] ---**
For your Gran's sake, too.
**[21:09] ---**
Huh! Acting so cool...
**[21:12] ---**
That's not what that was about.
**[21:15] ---**
*Once again, it really hit home.*
**[21:22] ---**
*That even if you're suffering,*
**[21:24] ---**
*and let yourself complain about it,*
**[21:26] ---**
*there's nothing you can do.*
**[21:27] ---**
*That's what a code black environment is.*
**[21:32] ---**
*Even so...*
**[21:34] ---**
*I...*
**[21:40] ---**
I'm feeling that power surge!
**[21:42] ---**
Awesome! Who knew that there was
still a heaven in this world?
**[21:46] ---**
This totally rocks!
**[23:19] ---**
PREVIEW
**[23:20] ---**
Here it comes!
I can feel it surging!
**[23:22] ---**
CAFFEINE
**[23:24] ---**
This is manna from heaven.
**[23:25] ---**
TEMPTATION
**[23:27] ---**
Even if I'm right next to him...
**[23:28] ---**
JEALOUSY
**[23:29] ---**
all I ever do is try to run away.
**[23:31] ---**
CAFFEINE, TEMPTATION, AND JEALOUSY