E11 - Desperation, Gout, and Rebellion
Source: Crunchyroll
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(Please feel free to edit the speaker names if incomplete or inaccurate. Names are handled on a best-effort basis depending on the info on the source file. Dialogue is left as is.)
[00:40] ---
ENUCLEATION CEREMONY
[00:48] ---
It's all my fault.
[00:51] ---
If only...
[00:53] ---
I'd turned back then...
[00:58] ---
It's all because of me...
[01:01] ---
that he...
[02:42] ---
EPISODE 11:
DESPERATION, GOUT,
AND REBELLION
[02:45] ---
WHITE BLOOD CELL
[02:45] ---
CELL
[02:49] ---
Hey! Good work!
[02:55] ---
Can't he hear us?
[03:02] ---
Ugh! This is messed up!
[03:04] ---
You've got that right.
[03:06] ---
The blood vessel's full of the waste products
it couldn't process.
[03:10] ---
There's been even more greasy food
and alcohol lately, so no wonder.
[03:16] ---
I'm sure it's all an outlet for stress,
but it's getting hard to take.
[03:20] ---
He's totally not getting enough exercise.
Just look at that!
[03:25] ---
The place is teeming
with Fat Cells, too, huh?
[03:28] ---
Fat Cells.
[03:30] ---
Cells that contain fat droplets
or what we call "oil."
[03:36] ---
They become enlarged with the consumption
of high-calorie foods and lack of exercise,
[03:40] ---
causing obesity.
[03:43] ---
I know! We can't go on like this!
[03:45] ---
No days off for us,
and none of us are getting any sleep!
[03:50] ---
If we don't get any time
to take care of ourselves,
[03:52] ---
of course it's only going to make
our work environment worse.
[03:56] ---
Seriously, what's going on
with this body anyway?
[04:01] ---
Sleep deprivation.
[04:03] ---
The brain's waste products
are absorbed by the cerebrospinal fluid
[04:06] ---
and excreted into the bloodstream.
[04:09] ---
But since this activity increases during sleep,
[04:12] ---
prolonged sleep deprivation can lead
to the impairment of brain functions.
[04:17] ---
The discord among the cells is only growing.
[04:21] ---
I just hope it doesn't lead to trouble.
[04:24] ---
Emergency! Emergency!
[04:26] ---
Bacteria sighting reported!
[04:28] ---
White Blood Cells are to head
to the site immediately!
[04:31] ---
Repeat! White Blood Cells,
please head to the site immediately!
[04:37] ---
An unknown bacterium has been detected
near the base of the left big toe!
[04:41] ---
Here's a visual!
[04:44] ---
What is this?
[04:46] ---
This is...
[04:51] ---
Senpai!
[04:52] ---
Thank goodness we were able to catch up!
[04:54] ---
There's a pathogen at large.
They say it's in the left big toe.
[04:57] ---
Why would it show up there, of all places?
[05:00] ---
You can look into that later.
[05:03] ---
- Right!
- Right!
[05:16] ---
Could the left big toe be any farther away?
[05:19] ---
Wait, where are the germs?
[05:21] ---
Since we're in the foot,
could it be athlete's foot again?
[05:24] ---
Well, not that anything could surprise us now.
[05:34] ---
Wh-What kind of germ is that?
[05:39] ---
It looks like really bad news!
[05:43] ---
Look at you, totally freaking out.
[05:45] ---
Who wouldn't freak out over that thing!
[05:47] ---
That germ is gigantic!
[05:50] ---
That one is definitely bad news!
[05:54] ---
Don't you have any insight
at all on him, Memory Cell?
[05:58] ---
Memory Cell.
[06:00] ---
A Lymphocyte that remembers
the immune responses of antigens.
[06:04] ---
When the same antigen invades the body,
[06:09] ---
they're prepared to trigger
accelerated antibody production.
[06:13] ---
Nothing.
[06:14] ---
Nothing here, either.
[06:16] ---
Or here or there! It's all...
[06:19] ---
That's...
[06:21] ---
the first pathogen
that we've ever encountered!
[06:24] ---
First encounter... In that case...
[06:27] ---
Right. Our first order of business
should be to gather the data.
[06:31] ---
White Blood Cells, phagocytose the target!
[06:33] ---
Macrophages, identify the antigen!
[06:36] ---
Copy that!
[06:37] ---
Understood.
[06:39] ---
Now then, let's go.
[06:47] ---
Phagocytosis.
[06:49] ---
The process by which White Blood Cells and the like
engulf bacteria and other foreign substances,
[06:53] ---
and break them down.
[06:55] ---
No taste?
[07:01] ---
How awful. To think
that our attacks are ineffective...
[07:05] ---
It's no good! We can't acquire immunity!
[07:08] ---
We still can't identify the pathogen!
[07:12] ---
Now that it's come to this,
we'll have to do whatever it takes!
[07:15] ---
Everyone, Battle Formation One!
[07:18] ---
Battle Formation One!
[07:20] ---
We've received a request
to get into Battle Formation One.
[07:23] ---
Did you say "Battle Formation One"?
[07:26] ---
Meaning we're up against a bacterium
that powerful?
[07:29] ---
All units, head to the left big toe immediately!
And deploy reinforcements in the rearguard!
[07:35] ---
Battle Formation One!
All units, head to the left big toe!
[07:40] ---
If there's some collateral damage, so be it!
[07:42] ---
Break through no matter what!
[07:45] ---
Battle Formation One, deployed!
[07:48] ---
Battle Formation One has been deployed!
[07:50] ---
Commence full assault!
[07:53] ---
Fire!
[08:09] ---
Hey, kiddo! You'd better make a run for it!
[08:12] ---
They say we're being attacked
by a new strain of bacteria!
[08:15] ---
Really, what's going on these days?
[08:19] ---
Oh my!
[08:20] ---
I wonder if he's okay.
[08:39] ---
Hey, you there!
[08:40] ---
Hey, I'm talking to you!
[08:45] ---
You were with him the other day, weren't you?
[08:53] ---
Hey there, aren't you going to stop by
for some tea today?
[08:57] ---
Hey, if there's ever anything
you want to grumble about, give me a holler!
[09:01] ---
My, my, how heartless!
[09:05] ---
You know, I haven't seen him lately.
[09:08] ---
He used to stop by all the time
and chat with me.
[09:14] ---
Oh right, you're him, right?
His classmate, the honor student?
[09:19] ---
Huh?
[09:20] ---
He used to talk about you all the time.
You could see how proud he was of you!
[09:27] ---
When work gets really tough
and all I want to do is bail,
[09:30] ---
I make myself think of him.
[09:32] ---
When I think, "Hey, he must be delivering oxygen
like the super straight arrow that he is,"
[09:37] ---
it gives me just enough energy
to dig in and work harder.
[09:41] ---
Well, I guess you could say
he's a friend I can trust.
[09:44] ---
No way would he ever betray me.
And I don't ever want to betray him, either.
[09:52] ---
You can't just make friends
that you can trust, even if you want to.
[09:57] ---
So, make sure you take care of him, all right?
[10:01] ---
I...
[10:03] ---
couldn't take care of him.
[10:05] ---
What?
[10:07] ---
I...
[10:09] ---
Hey you!
[10:17] ---
SPLEEN
[10:18] ---
The spleen.
[10:20] ---
About the size of a fist,
it's a spongy and soft organ.
[10:24] ---
It's made up of White Pulp and Red Pulp.
[10:28] ---
Red Blood Cells, please line up, proceed
through the gate and undergo your screening.
[10:42] ---
This is as far as you're going.
[10:45] ---
All right.
[10:47] ---
Red Pulp.
[10:49] ---
Filters the blood
and removes unneeded material.
[10:53] ---
In addition, it monitors
the Red Blood Cells' condition,
[10:56] ---
sorting out abnormal, old or damaged cells
that can no longer function.
[11:04] ---
Thank you so much
for all your hard work until now.
[11:13] ---
Aside from sorting blood and sending it
to the muscles when needed,
[11:20] ---
the spleen's other functions include producing
mature B Lymphocytes and T Lymphocytes,
[11:24] ---
and destroying the Red Blood Cells
sorted by the Red Pulp.
[11:30] ---
Red Blood Cells, do not stop. Please keep moving.
[11:39] ---
What's the matter? Keep going.
[11:43] ---
Please process me.
[11:46] ---
I can't work anymore.
[11:50] ---
A cell who can't work doesn't deserve to live.
[11:54] ---
Please...
[11:56] ---
process me.
[12:00] ---
You're still young...
[12:02] ---
and you're not malfunctioning in any way.
[12:05] ---
Get back to work.
[12:08] ---
Do you hear me? Get back to work.
[12:13] ---
Because of me...
[12:15] ---
Because of me, a friend of mine died.
[12:18] ---
Even though he trusted me.
[12:21] ---
I just wasn't the guy he thought I was.
[12:26] ---
I betrayed him.
[12:28] ---
I'm a useless cell who isn't fit to live!
[12:34] ---
I'm begging you.
[12:36] ---
J-Just end things for me, please!
[12:44] ---
Please...
[12:46] ---
put an end to me.
[12:51] ---
Don't get the wrong idea!
[12:55] ---
This isn't a place
where the useless get processed!
[12:58] ---
It's where the curtain goes down
[13:00] ---
on the lives of the Red Blood Cells
who've carried out their duties to the end!
[13:03] ---
And it's my job to determine who they are!
[13:07] ---
Somebody died because of you?
[13:09] ---
You're useless?
[13:11] ---
Who do you think you are?
[13:13] ---
You have a long way to go
before you can find purpose in your job!
[13:18] ---
Get up! Get up on your feet and move on!
[13:21] ---
Work! Cell!
[13:23] ---
Work!
[13:36] ---
Due to the battle with the unknown pathogen,
there are signs of inflammation everywhere!
[13:40] ---
At this rate, the damage is only going to spread
to the surrounding areas!
[13:44] ---
What the cell are we supposed to do?
[13:46] ---
Um, there's something
that's been bothering me.
[13:49] ---
What is it?
[13:50] ---
Suddenly showing up in a strange spot
like the base of the big toe...
[13:54] ---
Keeping even its infiltration point from us...
[13:57] ---
Is there a cell capable of such a thing?
[14:01] ---
Meaning it didn't come from outside.
[14:04] ---
Then, where the cell did it come from?
[14:07] ---
What's this displaying?
[14:08] ---
It's a graph showing
the uric acid levels in this area.
[14:12] ---
Uric acid? But these levels are...
[14:15] ---
Yes. They've been hovering
around the danger zone for days now.
[14:20] ---
Uric acid.
[14:21] ---
A waste by-product formed
during the breakdown of purines,
[14:25] ---
the energy substance produced in the body
when food is consumed or metabolized.
[14:31] ---
It is particularly insoluble in the bloodstream
of the extremities where the body temperature is low,
[14:35] ---
such as the lower torso and fingertips,
and is conducive to buildup.
[14:39] ---
Uric acid.
[14:41] ---
A mysterious pathogen.
[14:44] ---
I see! So, that's what it is!
[14:48] ---
What is it?
[14:49] ---
He's...
[14:50] ---
No, I mean that thing is no pathogen.
[14:53] ---
What?
[14:56] ---
Unscathed.
[14:57] ---
Seriously?
[14:59] ---
We know what it is!
[15:01] ---
It's uric acid that didn't get dissolved
in the bloodstream
[15:04] ---
and ended up crystallized as urate.
[15:07] ---
Crystallized uric acid?
[15:09] ---
Uric acid is a purine metabolite.
[15:12] ---
When there's excess purine intake
due to gorging, uric acid levels soar,
[15:16] ---
and we've been mistakenly attacking
that urate crystal as a pathogen.
[15:22] ---
We've actually triggered gout!
[15:28] ---
Gout.
[15:30] ---
Occurs when uric acid, a waste product
in the bloodstream, forms sharp crystals.
[15:33] ---
When these are attacked by White Blood Cells,
inflammation ensues, causing severe pain.
[15:40] ---
As pain can be triggered
merely by a gust of wind,
[15:43] ---
it came to be known as "painful wind."
[15:48] ---
Then,
[15:49] ---
that means that, in trying to protect this body...
[15:53] ---
we've actually been abusing it instead?
[16:00] ---
I-I don't believe this.
[16:06] ---
What does it matter?
[16:09] ---
Unless we inflict this much damage,
[16:11] ---
this body will never hear our cries.
[16:16] ---
Rookie?
[16:19] ---
No matter how hard we work, it's useless.
[16:23] ---
We have to change this body.
[16:30] ---
Open your eyes, dammit!
[16:33] ---
Do something about this work environment,
or there'll be no turning back!
[16:38] ---
Stop gorging on food and drink!
Stop smoking, too!
[16:41] ---
Get enough sleep!
[16:43] ---
Exercise, dammit!
[16:45] ---
He's right!
[16:47] ---
How the cell...
[16:48] ---
How the cell can we work
under these conditions?
[16:51] ---
Give us more vitamins!
[16:53] ---
Let us rest once in a while!
[16:55] ---
You're consuming too much nicotine!
[16:57] ---
Cut back on the alcohol!
[17:07] ---
Knock it off.
[17:11] ---
Come on, enough already!
[17:16] ---
Knock it off!
[17:17] ---
I said knock it off!
[17:18] ---
Please don't stop me!
[17:26] ---
You're absolutely right.
[17:28] ---
But what good will this do?
[17:32] ---
There's nothing else that I can do anymore.
[17:38] ---
All I can do is make an appeal
to this body like this.
[17:44] ---
I know.
[17:46] ---
No matter how hard we work,
[17:48] ---
unless this body changes,
[17:51] ---
this code black environment
will never change!
[17:54] ---
That's why we're all suffering.
[17:57] ---
I know only too well how you feel.
[18:00] ---
I don't know how many times
I've lost hope for this body myself.
[18:04] ---
In this world...
[18:06] ---
cells are born and die
at a breakneck pace.
[18:12] ---
We may all be different...
[18:14] ---
but we're all here to protect this body
and to carry out our tasks.
[18:21] ---
What we need to do as the ones left behind
[18:24] ---
is to keep this body going. The body
that our dear friends risked their lives to protect.
[18:30] ---
Not destroy it.
[18:34] ---
Let's take better care of it.
[18:37] ---
This world that our friends put their lives
on the line to protect...
[18:43] ---
And you yourself, as well...
[18:50] ---
It wasn't your fault that he died.
[18:54] ---
See? You forgot these.
[19:01] ---
Don't blame yourself anymore.
[19:04] ---
Don't try to shoulder the load by yourself.
[19:07] ---
Don't try to shoulder the load by yourself.
[19:22] ---
Please hear it.
[19:24] ---
Us cells crying out...
[19:27] ---
This body has reached its limit!
[19:34] ---
The White Blood Cells have ceased their attacks
on the urate crystal and have settled down.
[19:40] ---
The ingested coichicine
appears to be working.
[19:44] ---
Coichicine.
[19:45] ---
Inhibits microtubule polymerization
by binding to a protein called "tubulin,"
[19:53] ---
inhibiting White Blood Cell activity,
leading to an anti-inflammatory effect.
[19:58] ---
Used to treat gout.
[20:01] ---
As prolonged use can cause damage
to reproductive organs,
[20:05] ---
it must be taken with caution.
[20:07] ---
Even if we've suppressed
White Blood Cell activity,
[20:11] ---
nothing will change unless the purine levels
decrease and the uric acid levels go down.
[20:15] ---
But if this kind of inflammation keeps
recurring, it's going to be grim.
[20:20] ---
Aren't the naturally-supplied purines
going to decrease?
[20:24] ---
I don't know.
[20:25] ---
Can this body stop neglecting
its health after all these years?
[20:29] ---
And I really hope that the damage from all that
drinking and smoking will come to a stop.
[20:34] ---
The risk of a gout attack increases
when the blood uric acid level rises above 7 mg/dL,
[20:42] ---
and this state continues
for several years.
[20:44] ---
Female hormones can induce
the flushing out of uric acid,
[20:48] ---
and so, 90% of gout patients are male.
[20:52] ---
This is how close to the edge
this body's been driven by psychological stress.
[20:58] ---
I wonder who the real villain is here.
[21:13] ---
Come on, rookie! Run! Run!
[21:15] ---
You're never going to be done at this rate!
[21:17] ---
I'm sorry!
[21:19] ---
Jeez, we're even more understaffed than ever.
What the cell can we do?
[21:23] ---
The blood vessels are deteriorating
by the day, too.
[21:27] ---
Whoa!
[21:29] ---
And it's going to be a while
before the rookies will be of any use.
[21:41] ---
Oh my gosh! The oxygen!
[21:43] ---
Hey! What are you doing?
[23:19] ---
PREVIEW
[23:20] ---
Man, you really had me worried!
[23:22] ---
RETURN
[23:22] ---
To think that the coronary artery
could get completely clogged like this...
[23:26] ---
THE HEART
[23:26] ---
This condition is...
[23:27] ---
Ah, ah...
[23:28] ---
DEMISE
[23:29] ---
We will now hold an emergency
meeting for all cells.
[23:31] ---
RETURN, THE HEART, AND DEMISE
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