# E11 - Desperation, Gout, and Rebellion
Source: [Crunchyroll](https://www.crunchyroll.com/watch/GG1U2MQ47/desperation-gout-and-rebellion)
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(Please feel free to edit the speaker names if incomplete or inaccurate. Names are handled on a best-effort basis depending on the info on the source file. Dialogue is left as is.)
**[00:40] ---**
ENUCLEATION CEREMONY
**[00:48] ---**
It's all my fault.
**[00:51] ---**
If only...
**[00:53] ---**
I'd turned back then...
**[00:58] ---**
It's all because of me...
**[01:01] ---**
that he...
**[02:42] ---**
EPISODE 11:
DESPERATION, GOUT,
AND REBELLION
**[02:45] ---**
WHITE BLOOD CELL
**[02:45] ---**
CELL
**[02:49] ---**
*Hey! Good work!*
**[02:55] ---**
*Can't he hear us?*
**[03:02] ---**
Ugh! This is messed up!
**[03:04] ---**
You've got that right.
**[03:06] ---**
The blood vessel's full of the waste products
it couldn't process.
**[03:10] ---**
There's been even more greasy food
and alcohol lately, so no wonder.
**[03:16] ---**
I'm sure it's all an outlet for stress,
but it's getting hard to take.
**[03:20] ---**
He's totally not getting enough exercise.
Just look at that!
**[03:25] ---**
The place is teeming
with Fat Cells, too, huh?
**[03:28] ---**
*Fat Cells.*
**[03:30] ---**
*Cells that contain fat droplets
or what we call "oil."*
**[03:36] ---**
*They become enlarged with the consumption
of high-calorie foods and lack of exercise,*
**[03:40] ---**
*causing obesity.*
**[03:43] ---**
I know! We can't go on like this!
**[03:45] ---**
No days off for us,
and none of us are getting any sleep!
**[03:50] ---**
If we don't get any time
to take care of ourselves,
**[03:52] ---**
of course it's only going to make
our work environment worse.
**[03:56] ---**
Seriously, what's going on
with this body anyway?
**[04:01] ---**
*Sleep deprivation.*
**[04:03] ---**
*The brain's waste products
are absorbed by the cerebrospinal fluid*
**[04:06] ---**
*and excreted into the bloodstream.*
**[04:09] ---**
*But since this activity increases during sleep,*
**[04:12] ---**
*prolonged sleep deprivation can lead
to the impairment of brain functions.*
**[04:17] ---**
*The discord among the cells is only growing.*
**[04:21] ---**
*I just hope it doesn't lead to trouble.*
**[04:24] ---**
*Emergency! Emergency!*
**[04:26] ---**
*Bacteria sighting reported!*
**[04:28] ---**
*White Blood Cells are to head
to the site immediately!*
**[04:31] ---**
*Repeat! White Blood Cells,
please head to the site immediately!*
**[04:37] ---**
An unknown bacterium has been detected
near the base of the left big toe!
**[04:41] ---**
Here's a visual!
**[04:44] ---**
What is this?
**[04:46] ---**
This is...
**[04:51] ---**
Senpai!
**[04:52] ---**
Thank goodness we were able to catch up!
**[04:54] ---**
There's a pathogen at large.
They say it's in the left big toe.
**[04:57] ---**
Why would it show up there, of all places?
**[05:00] ---**
You can look into that later.
**[05:03] ---**
- Right!
- Right!
**[05:16] ---**
Could the left big toe be any farther away?
**[05:19] ---**
Wait, where are the germs?
**[05:21] ---**
Since we're in the foot,
could it be athlete's foot again?
**[05:24] ---**
Well, not that anything could surprise us now.
**[05:34] ---**
Wh-What kind of germ is that?
**[05:39] ---**
It looks like really bad news!
**[05:43] ---**
Look at you, totally freaking out.
**[05:45] ---**
Who wouldn't freak out over that thing!
**[05:47] ---**
That germ is gigantic!
**[05:50] ---**
That one is definitely bad news!
**[05:54] ---**
Don't you have any insight
at all on him, Memory Cell?
**[05:58] ---**
*Memory Cell.*
**[06:00] ---**
*A Lymphocyte that remembers
the immune responses of antigens.*
**[06:04] ---**
*When the same antigen invades the body,*
**[06:09] ---**
*they're prepared to trigger
accelerated antibody production.*
**[06:13] ---**
Nothing.
**[06:14] ---**
Nothing here, either.
**[06:16] ---**
Or here or there! It's all...
**[06:19] ---**
That's...
**[06:21] ---**
the first pathogen
that we've ever encountered!
**[06:24] ---**
First encounter... In that case...
**[06:27] ---**
Right. Our first order of business
should be to gather the data.
**[06:31] ---**
*White Blood Cells, phagocytose the target!*
**[06:33] ---**
*Macrophages, identify the antigen!*
**[06:36] ---**
Copy that!
**[06:37] ---**
Understood.
**[06:39] ---**
Now then, let's go.
**[06:47] ---**
*Phagocytosis.*
**[06:49] ---**
*The process by which White Blood Cells and the like
engulf bacteria and other foreign substances,*
**[06:53] ---**
*and break them down.*
**[06:55] ---**
No taste?
**[07:01] ---**
How awful. To think
that our attacks are ineffective...
**[07:05] ---**
It's no good! We can't acquire immunity!
**[07:08] ---**
We still can't identify the pathogen!
**[07:12] ---**
Now that it's come to this,
we'll have to do whatever it takes!
**[07:15] ---**
Everyone, Battle Formation One!
**[07:18] ---**
Battle Formation One!
**[07:20] ---**
We've received a request
to get into Battle Formation One.
**[07:23] ---**
Did you say "Battle Formation One"?
**[07:26] ---**
Meaning we're up against a bacterium
that powerful?
**[07:29] ---**
All units, head to the left big toe immediately!
And deploy reinforcements in the rearguard!
**[07:35] ---**
Battle Formation One!
All units, head to the left big toe!
**[07:40] ---**
*If there's some collateral damage, so be it!*
**[07:42] ---**
*Break through no matter what!*
**[07:45] ---**
Battle Formation One, deployed!
**[07:48] ---**
Battle Formation One has been deployed!
**[07:50] ---**
Commence full assault!
**[07:53] ---**
Fire!
**[08:09] ---**
Hey, kiddo! You'd better make a run for it!
**[08:12] ---**
They say we're being attacked
by a new strain of bacteria!
**[08:15] ---**
Really, what's going on these days?
**[08:19] ---**
Oh my!
**[08:20] ---**
I wonder if he's okay.
**[08:39] ---**
Hey, you there!
**[08:40] ---**
Hey, I'm talking to you!
**[08:45] ---**
You were with him the other day, weren't you?
**[08:53] ---**
*Hey there, aren't you going to stop by
for some tea today?*
**[08:57] ---**
*Hey, if there's ever anything
you want to grumble about, give me a holler!*
**[09:01] ---**
*My, my, how heartless!*
**[09:05] ---**
You know, I haven't seen him lately.
**[09:08] ---**
He used to stop by all the time
and chat with me.
**[09:14] ---**
Oh right, you're him, right?
His classmate, the honor student?
**[09:19] ---**
Huh?
**[09:20] ---**
He used to talk about you all the time.
You could see how proud he was of you!
**[09:27] ---**
*When work gets really tough
and all I want to do is bail,*
**[09:30] ---**
*I make myself think of him.*
**[09:32] ---**
*When I think, "Hey, he must be delivering oxygen
like the super straight arrow that he is,"*
**[09:37] ---**
*it gives me just enough energy
to dig in and work harder.*
**[09:41] ---**
*Well, I guess you could say
he's a friend I can trust.*
**[09:44] ---**
*No way would he ever betray me.
And I don't ever want to betray him, either.*
**[09:52] ---**
You can't just make friends
that you can trust, even if you want to.
**[09:57] ---**
So, make sure you take care of him, all right?
**[10:01] ---**
I...
**[10:03] ---**
couldn't take care of him.
**[10:05] ---**
What?
**[10:07] ---**
I...
**[10:09] ---**
Hey you!
**[10:17] ---**
SPLEEN
**[10:18] ---**
*The spleen.*
**[10:20] ---**
*About the size of a fist,
it's a spongy and soft organ.*
**[10:24] ---**
*It's made up of White Pulp and Red Pulp.*
**[10:28] ---**
*Red Blood Cells, please line up, proceed
through the gate and undergo your screening.*
**[10:42] ---**
This is as far as you're going.
**[10:45] ---**
All right.
**[10:47] ---**
*Red Pulp.*
**[10:49] ---**
*Filters the blood
and removes unneeded material.*
**[10:53] ---**
*In addition, it monitors
the Red Blood Cells' condition,*
**[10:56] ---**
*sorting out abnormal, old or damaged cells
that can no longer function.*
**[11:04] ---**
Thank you so much
for all your hard work until now.
**[11:13] ---**
*Aside from sorting blood and sending it
to the muscles when needed,*
**[11:20] ---**
*the spleen's other functions include producing
mature B Lymphocytes and T Lymphocytes,*
**[11:24] ---**
*and destroying the Red Blood Cells
sorted by the Red Pulp.*
**[11:30] ---**
*Red Blood Cells, do not stop. Please keep moving.*
**[11:39] ---**
What's the matter? Keep going.
**[11:43] ---**
Please process me.
**[11:46] ---**
I can't work anymore.
**[11:50] ---**
A cell who can't work doesn't deserve to live.
**[11:54] ---**
Please...
**[11:56] ---**
process me.
**[12:00] ---**
You're still young...
**[12:02] ---**
and you're not malfunctioning in any way.
**[12:05] ---**
Get back to work.
**[12:08] ---**
Do you hear me? Get back to work.
**[12:13] ---**
Because of me...
**[12:15] ---**
Because of me, a friend of mine died.
**[12:18] ---**
Even though he trusted me.
**[12:21] ---**
I just wasn't the guy he thought I was.
**[12:26] ---**
I betrayed him.
**[12:28] ---**
I'm a useless cell who isn't fit to live!
**[12:34] ---**
I'm begging you.
**[12:36] ---**
J-Just end things for me, please!
**[12:44] ---**
Please...
**[12:46] ---**
put an end to me.
**[12:51] ---**
Don't get the wrong idea!
**[12:55] ---**
This isn't a place
where the useless get processed!
**[12:58] ---**
It's where the curtain goes down
**[13:00] ---**
on the lives of the Red Blood Cells
who've carried out their duties to the end!
**[13:03] ---**
And it's my job to determine who they are!
**[13:07] ---**
Somebody died because of you?
**[13:09] ---**
You're useless?
**[13:11] ---**
Who do you think you are?
**[13:13] ---**
You have a long way to go
before you can find purpose in your job!
**[13:18] ---**
Get up! Get up on your feet and move on!
**[13:21] ---**
Work! Cell!
**[13:23] ---**
Work!
**[13:36] ---**
Due to the battle with the unknown pathogen,
there are signs of inflammation everywhere!
**[13:40] ---**
At this rate, the damage is only going to spread
to the surrounding areas!
**[13:44] ---**
What the cell are we supposed to do?
**[13:46] ---**
Um, there's something
that's been bothering me.
**[13:49] ---**
What is it?
**[13:50] ---**
Suddenly showing up in a strange spot
like the base of the big toe...
**[13:54] ---**
Keeping even its infiltration point from us...
**[13:57] ---**
Is there a cell capable of such a thing?
**[14:01] ---**
Meaning it didn't come from outside.
**[14:04] ---**
Then, where the cell did it come from?
**[14:07] ---**
What's this displaying?
**[14:08] ---**
It's a graph showing
the uric acid levels in this area.
**[14:12] ---**
Uric acid? But these levels are...
**[14:15] ---**
Yes. They've been hovering
around the danger zone for days now.
**[14:20] ---**
*Uric acid.*
**[14:21] ---**
*A waste by-product formed
during the breakdown of purines,*
**[14:25] ---**
*the energy substance produced in the body
when food is consumed or metabolized.*
**[14:31] ---**
*It is particularly insoluble in the bloodstream
of the extremities where the body temperature is low,*
**[14:35] ---**
*such as the lower torso and fingertips,
and is conducive to buildup.*
**[14:39] ---**
Uric acid.
**[14:41] ---**
A mysterious pathogen.
**[14:44] ---**
I see! So, that's what it is!
**[14:48] ---**
What is it?
**[14:49] ---**
He's...
**[14:50] ---**
No, I mean that thing is no pathogen.
**[14:53] ---**
What?
**[14:56] ---**
Unscathed.
**[14:57] ---**
Seriously?
**[14:59] ---**
*We know what it is!*
**[15:01] ---**
*It's uric acid that didn't get dissolved
in the bloodstream*
**[15:04] ---**
*and ended up crystallized as urate.*
**[15:07] ---**
Crystallized uric acid?
**[15:09] ---**
Uric acid is a purine metabolite.
**[15:12] ---**
When there's excess purine intake
due to gorging, uric acid levels soar,
**[15:16] ---**
and we've been mistakenly attacking
that urate crystal as a pathogen.
**[15:22] ---**
We've actually triggered gout!
**[15:28] ---**
*Gout.*
**[15:30] ---**
*Occurs when uric acid, a waste product
in the bloodstream, forms sharp crystals.*
**[15:33] ---**
*When these are attacked by White Blood Cells,
inflammation ensues, causing severe pain.*
**[15:40] ---**
*As pain can be triggered
merely by a gust of wind,*
**[15:43] ---**
*it came to be known as "painful wind."*
**[15:48] ---**
Then,
**[15:49] ---**
that means that, in trying to protect this body...
**[15:53] ---**
we've actually been abusing it instead?
**[16:00] ---**
I-I don't believe this.
**[16:06] ---**
What does it matter?
**[16:09] ---**
Unless we inflict this much damage,
**[16:11] ---**
this body will never hear our cries.
**[16:16] ---**
Rookie?
**[16:19] ---**
No matter how hard we work, it's useless.
**[16:23] ---**
We have to change this body.
**[16:30] ---**
Open your eyes, dammit!
**[16:33] ---**
Do something about this work environment,
or there'll be no turning back!
**[16:38] ---**
Stop gorging on food and drink!
Stop smoking, too!
**[16:41] ---**
Get enough sleep!
**[16:43] ---**
Exercise, dammit!
**[16:45] ---**
He's right!
**[16:47] ---**
How the cell...
**[16:48] ---**
How the cell can we work
under these conditions?
**[16:51] ---**
Give us more vitamins!
**[16:53] ---**
Let us rest once in a while!
**[16:55] ---**
You're consuming too much nicotine!
**[16:57] ---**
Cut back on the alcohol!
**[17:07] ---**
Knock it off.
**[17:11] ---**
Come on, enough already!
**[17:16] ---**
Knock it off!
**[17:17] ---**
I said knock it off!
**[17:18] ---**
Please don't stop me!
**[17:26] ---**
You're absolutely right.
**[17:28] ---**
But what good will this do?
**[17:32] ---**
There's nothing else that I can do anymore.
**[17:38] ---**
All I can do is make an appeal
to this body like this.
**[17:44] ---**
I know.
**[17:46] ---**
No matter how hard we work,
**[17:48] ---**
unless this body changes,
**[17:51] ---**
this code black environment
will never change!
**[17:54] ---**
That's why we're all suffering.
**[17:57] ---**
I know only too well how you feel.
**[18:00] ---**
I don't know how many times
I've lost hope for this body myself.
**[18:04] ---**
In this world...
**[18:06] ---**
cells are born and die
at a breakneck pace.
**[18:12] ---**
We may all be different...
**[18:14] ---**
but we're all here to protect this body
and to carry out our tasks.
**[18:21] ---**
What we need to do as the ones left behind
**[18:24] ---**
is to keep this body going. The body
that our dear friends risked their lives to protect.
**[18:30] ---**
Not destroy it.
**[18:34] ---**
Let's take better care of it.
**[18:37] ---**
This world that our friends put their lives
on the line to protect...
**[18:43] ---**
And you yourself, as well...
**[18:50] ---**
It wasn't your fault that he died.
**[18:54] ---**
See? You forgot these.
**[19:01] ---**
Don't blame yourself anymore.
**[19:04] ---**
Don't try to shoulder the load by yourself.
**[19:07] ---**
*Don't try to shoulder the load by yourself.*
**[19:22] ---**
*Please hear it.*
**[19:24] ---**
*Us cells crying out...*
**[19:27] ---**
*This body has reached its limit!*
**[19:34] ---**
The White Blood Cells have ceased their attacks
on the urate crystal and have settled down.
**[19:40] ---**
The ingested coichicine
appears to be working.
**[19:44] ---**
*Coichicine.*
**[19:45] ---**
*Inhibits microtubule polymerization
by binding to a protein called "tubulin,"*
**[19:53] ---**
*inhibiting White Blood Cell activity,
leading to an anti-inflammatory effect.*
**[19:58] ---**
*Used to treat gout.*
**[20:01] ---**
*As prolonged use can cause damage
to reproductive organs,*
**[20:05] ---**
*it must be taken with caution.*
**[20:07] ---**
Even if we've suppressed
White Blood Cell activity,
**[20:11] ---**
nothing will change unless the purine levels
decrease and the uric acid levels go down.
**[20:15] ---**
But if this kind of inflammation keeps
recurring, it's going to be grim.
**[20:20] ---**
Aren't the naturally-supplied purines
going to decrease?
**[20:24] ---**
I don't know.
**[20:25] ---**
Can this body stop neglecting
its health after all these years?
**[20:29] ---**
And I really hope that the damage from all that
drinking and smoking will come to a stop.
**[20:34] ---**
*The risk of a gout attack increases
when the blood uric acid level rises above 7 mg/dL,*
**[20:42] ---**
*and this state continues
for several years.*
**[20:44] ---**
*Female hormones can induce
the flushing out of uric acid,*
**[20:48] ---**
*and so, 90% of gout patients are male.*
**[20:52] ---**
This is how close to the edge
this body's been driven by psychological stress.
**[20:58] ---**
I wonder who the real villain is here.
**[21:13] ---**
Come on, rookie! Run! Run!
**[21:15] ---**
You're never going to be done at this rate!
**[21:17] ---**
I'm sorry!
**[21:19] ---**
Jeez, we're even more understaffed than ever.
What the cell can we do?
**[21:23] ---**
The blood vessels are deteriorating
by the day, too.
**[21:27] ---**
Whoa!
**[21:29] ---**
And it's going to be a while
before the rookies will be of any use.
**[21:41] ---**
Oh my gosh! The oxygen!
**[21:43] ---**
Hey! What are you doing?
**[23:19] ---**
PREVIEW
**[23:20] ---**
Man, you really had me worried!
**[23:22] ---**
RETURN
**[23:22] ---**
To think that the coronary artery
could get completely clogged like this...
**[23:26] ---**
THE HEART
**[23:26] ---**
This condition is...
**[23:27] ---**
Ah, ah...
**[23:28] ---**
DEMISE
**[23:29] ---**
We will now hold an emergency
meeting for all cells.
**[23:31] ---**
RETURN, THE HEART, AND DEMISE