E2 - The Liver, Alcohol, and Pride

Source: Crunchyroll
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(Please feel free to edit the speaker names if incomplete or inaccurate. Names are handled on a best-effort basis depending on the info on the source file. Dialogue is left as is.)
[00:01] ---
    For your next deliveries, you'll be
    going here, here, here and here.
[00:05] ---
    This many?
[00:06] ---
    You've got a problem?
[00:08] ---
    This is me giving you a lighter load
    since you're a rookie.
[00:11] ---
    Right.
[00:13] ---
    I'll be heading out now.
[00:14] ---
    Whatever you do, don't forget
    to get those receipts stamped!
[00:17] ---
    R-Right.
[00:20] ---
    Am I ever going to be done?
[00:22] ---
    Hey, rookie, could you be any slower?
[00:26] ---
    - Sorry!
    - I don't believe it.
[00:28] ---
    You haven't even gotten through
    half of your quota yet!
[00:31] ---
    What kind of plan do you have
    for delivering this oxygen anyway?
[00:35] ---
    - Or maybe you're just slacking off?
    - I am not—
[00:38] ---
    Oh well, what do I care?
[00:40] ---
    Why don't you start
    by picking up the pace?
[00:42] ---
    Here, I'm adding these, too.
[00:44] ---
    Huh?
[00:45] ---
    I know you can do it!
[00:46] ---
    Prove to me that
    you haven't been slacking off, okay?
[00:51] ---
    I see you're having a hard time, too, huh?
[00:53] ---
    Yeah.
[00:55] ---
    Talk about overwhelmed!
[02:33] ---
    EPISODE 2:
    THE LIVER, ALCOHOL, AND PRIDE
[02:33] ---
    Okay, let's get going.
[02:34] ---
    Sure. See ya.
[02:35] ---
    See ya.
[02:38] ---
    Th-That's a Macrophage.
[02:41] ---
    They're all so pretty.
[02:44] ---
    Huh?
[02:50] ---
    What?
[02:51] ---
    Macrophage.
[02:53] ---
    A type of White Blood Cell.
[02:55] ---
    Catches and kills
    foreign substances like bacteria,
[02:58] ---
    while determining antigens
    and information about immune responses.
[03:01] ---
    I have to kill more. More...
[03:10] ---
    Oh my, so you're a Red Blood Cell.
[03:13] ---
    Y-Yes.
[03:15] ---
    I thought you were a bacterium!
[03:17] ---
    My sincerest apologies.
[03:23] ---
    Man, that Macrophage is exhausted, too.
[03:28] ---
    Next is the Mucosal Cell in the oral cavity.
[03:31] ---
    ORAL MUCOSAL EPITHELIUM
[03:31] ---
    This way, huh?
[03:33] ---
    Mucosal Cell?
    I've come to deliver your oxy—
[03:38] ---
    It's on fire?
[03:39] ---
    Mouth ulcer.
[03:41] ---
    An inflammation inside of the mouth
    or on the tongue.
[03:43] ---
    When the lesions are round, shallow
    and have a distinct border,
[03:47] ---
    they are called "aphthous."
[03:49] ---
    Often caused by stress, sleep deprivation
    and lack of oral hygiene.
[03:55] ---
    A-Are you Mucosal Cell?
[03:58] ---
    Oral mucosa.
[03:59] ---
    The mucous membrane
    lining the inside of the mouth.
[04:02] ---
    Also known as the mirror
    reflecting one's physical health.
[04:06] ---
    WORKFLOW MANUAL
    FOR RED BLOOD CELLS
[04:06] ---
    When this kind of thing happens...
[04:11] ---
    DURING DELIVERIES,
    TRANSFERAL OF THE OXYGEN
    MUST BE YOUR TOP PRIORITY!
[04:11] ---
    "Top priority"?
[04:15] ---
    Your seal...
[04:17] ---
    U-Um, th-this receipt...
[04:21] ---
    Please stamp this receipt!
[04:27] ---
    The receipt!
[04:34] ---
    Don't worry about stuff like that!
[04:36] ---
    All we need to do is suppress our emotions
    and deliver oxygen in silence!
[04:42] ---
    No way can I do that.
[04:44] ---
    No way.
[04:46] ---
    - Run.
    - What?
[04:48] ---
    The mouth ulcer ruptured.
[04:50] ---
    We'll soon be invaded by bacteria!
[05:06] ---
    Stay away!
[05:08] ---
    Stay away from me!
[05:14] ---
    White Blood Cell!
[05:17] ---
    WHITE BLOOD CELL
[05:24] ---
    That was uncalled for.
[05:26] ---
    Hey, don't be that way, Senpai.
[05:31] ---
    She's right. After all,
    it was such a hassle getting here.
[05:37] ---
    Th-Thank you so much!
[05:39] ---
    You?
[05:41] ---
    We've met before.
[05:44] ---
    You remember me?
[05:46] ---
    Too bad.
[05:47] ---
    You get extra points for the glasses,
    but you're too slim.
[05:51] ---
    I hear you! If only he was
    just a little more macho-looking, right?
[06:04] ---
    Phagocytosis or Phagocytic Effects.
[06:06] ---
    When Phagocytes, such as Monocytes,
    Macrophages and Neutrophils
[06:11] ---
    engulf bacteria and other foreign
    substances, and break them down.
[06:27] ---
    This is your precious oxygen, right?
[06:29] ---
    Don't ever let it go even if it kills you.
[06:31] ---
    R-Right!
[06:35] ---
    Not good!
[06:36] ---
    Hold onto something!
[06:47] ---
    What's going on?
[06:48] ---
    We're being engulfed by water and povidone-iodine
    from the damaged area! This is...
[06:53] ---
    It's gargling!
[06:55] ---
    Gargling.
[06:56] ---
    To wash away bacteria and viruses
    in the mouth,
[07:00] ---
    preventing respiratory tract inflammation.
    Various theories exist.
[07:03] ---
    Povidone-iodine.
[07:05] ---
    An antiseptic used in gargling solutions.
[07:08] ---
    Though it has a unique scent,
    it's highly effective as an antiseptic.
[07:13] ---
    - Where'd that come from?
    - Jeez, that's gross.
[07:23] ---
    Good job hanging onto that oxygen.
[07:25] ---
    Y-Yes. Thank you very much.
[07:29] ---
    Hang in there, rookie.
[07:32] ---
    See you later, Glasses!
[07:34] ---
    Build up that body of yours!
[07:41] ---
    Hey, Glasses is totally staring at us!
[07:44] ---
    Do you think maybe he's smitten with Senpai?
[07:48] ---
    Save your breath, will you?
[07:50] ---
    Right!
[07:53] ---
    I'm so wiped.
[07:55] ---
    No rest since Day One.
    How many rounds do we have to do in a day?
[08:01] ---
    I came this close to dying three times.
[08:03] ---
    I'm telling you, I can't take
    much more of this job.
[08:06] ---
    Are you okay, rookies?
[08:09] ---
    Oh, good work, sirs!
[08:10] ---
    It's all right, stay seated. The stress is more intense
    than usual today, so I bet it's a lot to take in, huh?
[08:16] ---
    Just my veteran's gut,
    but a day like this, it's going to rain.
[08:20] ---
    Rain?
[08:22] ---
    Wh-What's this?
[08:24] ---
    Hey, simmer down. This is alcohol.
[08:28] ---
    Alcohol.
[08:30] ---
    Upon entering the body,
    it has the effect of alleviating tension
[08:33] ---
    by temporarily improving circulation and inducing
    the secretion of dopamine and serotonin.
[08:39] ---
    Alcohol?
[08:41] ---
    You can count on this happening
    after overwhelming stress.
[08:45] ---
    Sure, it improves the circulation,
[08:46] ---
    but then the body absorbs more fat,
    making the blood all viscous.
[08:50] ---
    At this rate, we'll be delivering alcohol
    all over the body.
[08:53] ---
    The other cells are going to be pissed.
[08:55] ---
    This stupid job... This stupid job...
[08:59] ---
    Why should we do it?
    Give us some days off!
[09:02] ---
    Give us a long weekend off!
[09:04] ---
    I didn't... I didn't become
    a Red Blood Cell for this!
[09:14] ---
    Hey, hey, get a grip.
[09:16] ---
    You're not used to alcohol, huh?
    No way around it! Come with me.
[09:21] ---
    Even we need a break sometimes, right?
[09:25] ---
    How about we get some healing
    and refresh ourselves?
[09:30] ---
    We're here.
[09:32] ---
    This is the liver.
[09:33] ---
    LIVER
[09:34] ---
    The liver.
[09:35] ---
    An organ that performs
    a wide variety of functions,
[09:37] ---
    such as the synthesis, excretion
    and detoxification of substances.
[09:42] ---
    Woo-hoo! I've always wanted to visit the liver!
[09:46] ---
    It sure is lively here.
[09:46] ---
    BLOOD ALLEY
    BILE TOWN
    FIRST AVENUE
[09:48] ---
    Well, of course.
    The liver is the largest organ in the body.
[09:53] ---
    Not only does it metabolize
    the Big Three nutrients...
[09:55] ---
    but it also handles all kinds of tasks
    like producing bile and breaking down toxins.
[10:01] ---
    So, it's a really crucial organ, huh?
[10:04] ---
    Is this your first time, rookie?
[10:06] ---
    Y-Yes.
[10:07] ---
    Normally, I get by just dealing
    with oxygen and nutrients, so—
[10:13] ---
    We'll show you how to really have fun in the liver.
[10:17] ---
    Hey! Why don't you detox with us,
    Red Blood Cell gentlemen?
[10:21] ---
    Come on, let's go!
[10:23] ---
    Jeez, just can't get enough of that, huh, Gramps?
[10:26] ---
    I'm coming! I'm coming!
[10:28] ---
    Um, what do you mean by "detox"?
[10:31] ---
    I brought along some youngsters. It's their first time,
    so send them some sweet young things, okay?
[10:36] ---
    Consider it done, since you're always
    such good customers. This way, please.
[10:44] ---
    Some guests have arrived!
[10:47] ---
    Welcome!
[11:03] ---
    You youngsters don't hold back
    with your reactions. Good for you!
[11:07] ---
    I-It's not like I'm reacting!
[11:09] ---
    Thank you for your patience!
[11:11] ---
    We'll be seating you in groups of three!
[11:14] ---
    Hepatocytes, please take Table 3!
[11:18] ---
    Welcome, Red Blood Cells.
[11:22] ---
    Please refresh yourselves tonight.
[11:25] ---
    Hepatocytes.
[11:27] ---
    Cells that make up 70 to 80% of the liver.
[11:31] ---
    They metabolize and detoxify substances.
[11:35] ---
    - N-Nice to meet you.
    - Is this your first time coming to a place like this?
[11:39] ---
    Yes! It's our first time!
[11:43] ---
    Wonderful, isn't it, rookie? Having a gorgeous
    Hepatocyte like this help us detox!
[11:48] ---
    What do you mean by "detox"?
[11:51] ---
    Right, here you go.
[11:52] ---
    Huh? What's this?
[11:54] ---
    This is ADH.
[11:56] ---
    ADH?
[11:58] ---
    That's right. It's an enzyme
    that breaks down alcohol.
[12:02] ---
    ADH.
[12:04] ---
    An enzyme present in the Hepatocytes.
[12:06] ---
    Has the ability to convert
    alcohol into acetaldehyde.
[12:10] ---
    Alcohol is a substance
    that triggers intoxication, right?
[12:13] ---
    It's our job as Hepatocytes to break down
    and detoxify alcohol in the blood to sober you up.
[12:20] ---
    Oh, so that's what "detox" means.
[12:23] ---
    Goro can't dwink ADH by himself!
[12:27] ---
    Dwink?
[12:28] ---
    What am I going to do with you?
    Here, there you go!
[12:36] ---
    Don't cringe at me, dummy!
[12:38] ---
    When you're at a place like this,
    just forget all about work and have a good time!
[12:42] ---
    R-Right.
[12:47] ---
    Forget all about work...
[12:56] ---
    You really chugged that!
[12:57] ---
    - That was hot!
    - For real?
[12:59] ---
    Gimme a "That's a good boy!"
[13:02] ---
    That's a good boy!
[13:04] ---
    What's wrong?
[13:06] ---
    You have a frown on your face.
[13:08] ---
    It's nothing.
[13:10] ---
    You owe it to yourself to have some fun.
[13:13] ---
    He's right! Drink up and refresh yourself!
[13:15] ---
    Okay.
[13:20] ---
    That was great!
    Good job downing that!
[13:23] ---
    I'm starting to feel queasy.
[13:25] ---
    I'm telling you, I can't take it!
[13:28] ---
    The blood vessels are so uneven,
    trying to walk through them is a joke!
[13:31] ---
    The higher-ups aren't giving us
    a second thought!
[13:35] ---
    Damn it! They have to improve
    our working conditions or we can't go on!
[13:41] ---
    That's right!
[13:42] ---
    Don't we even get paid time off?
    Where's our paid time off?
[13:45] ---
    Wh-What's that?
    That black haze...
[13:48] ---
    That's acetaldehyde.
[13:50] ---
    Huh?
[13:51] ---
    Acetaldehyde is what you get
    when alcohol is metabolized by ADH.
[13:56] ---
    It's a powerful toxin,
    but to eliminate alcohol completely,
[14:00] ---
    you need to convert it
    to this substance first.
[14:03] ---
    Acetaldehyde.
[14:05] ---
    A highly toxic substance.
[14:08] ---
    Can also be found in automobile
    exhaust fumes and tobacco smoke.
[14:12] ---
    A toxin?
[14:14] ---
    That's why everyone's pissed
    and out of control.
[14:17] ---
    All right, the next step is...
[14:22] ---
    What's that?
[14:23] ---
    An enzyme called "ALDH."
[14:26] ---
    ALDH.
[14:28] ---
    An enzyme that metabolizes acetaldehyde
    into acetic acid, detoxifying it.
[14:33] ---
    Acetic acid is ultimately converted into water
    and carbon dioxide, then expelled from the body.
[14:39] ---
    If you detoxify the acetaldehyde
    by metabolizing it,
[14:42] ---
    it will sober you up completely.
[14:45] ---
    Now, does everyone have a glass of ALDH?
[14:49] ---
    Once again, let's raise a glass
    to working healthy again tomorrow!
[14:54] ---
    Cheers!
[14:55] ---
    Cheers!
[15:00] ---
    Transport the oxygen!
[15:16] ---
    How can I be in the mood to raise a glass?
[15:21] ---
    Can we just erase it all with this enzyme?
[15:24] ---
    All our suffering...
[15:26] ---
    Rookie?
[15:27] ---
    Every day, all we do
    is run around delivering oxygen.
[15:32] ---
    We're so easily replaceable.
[15:35] ---
    One or two drops of blood being shed
    isn't going to affect this body in any way!
[15:40] ---
    Oh, don't talk like that.
    In one go, all right?
[15:44] ---
    What do you...
[15:46] ---
    What do you people know about it?
[15:50] ---
    Aren't the internal organs and the bowels
    where the elite work?
[15:53] ---
    A safe spot from where you can watch us
    scrambling around?
[15:56] ---
    People like you with such carefree jobs...
[15:59] ---
    You don't know anything about our pain!
[16:05] ---
    That's enough. You're a really bad drunk.
[16:10] ---
    Are you all right?
[16:12] ---
    I'll bring you another glass right away.
[16:17] ---
    Rookie...
[16:20] ---
    Come with me.
[16:23] ---
    Are you all right?
[16:25] ---
    I'm sorry.
    There's been so much alcohol lately.
[16:29] ---
    Why don't you take a break?
[16:31] ---
    I'll be fine.
[16:33] ---
    The other Hepatocytes have been hit hard by the
    acetaldehyde toxins, but they're soldiering on.
[16:40] ---
    Liver failure.
[16:42] ---
    Overconsumption of alcohol
    can lead to a fatty liver
[16:46] ---
    due to acetaldehyde inhibiting
    the breakdown of fats.
[16:50] ---
    Chronic binging will eventually destroy
    the liver cells, triggering hepatic cirrhosis.
[16:58] ---
    We're not the only ones who are suffering.
[17:01] ---
    The Red Blood Cells risk their lives
    to work like crazy for us.
[17:07] ---
    As long as they're here,
    I don't want them to see me being weak.
[17:16] ---
    I've seen all kinds of cells over the years,
[17:19] ---
    but there isn't one single easy task
    in this world.
[17:22] ---
    Well, I guess you've been through a lot.
[17:25] ---
    If an old geezer like me will do, talk to me.
[17:30] ---
    I...
[17:31] ---
    I...
[17:33] ---
    I just ran off!
[17:36] ---
    Bailing on the job I was supposed to do...
[17:40] ---
    Because of that, S-Senpai...
[17:44] ---
    My only task is to deliver oxygen,
    but I can't even get that right!
[17:49] ---
    I'm not blaming you.
[17:52] ---
    The longer you live,
    the more shame you suffer.
[17:55] ---
    I've been scrambling around myself,
    just like you.
[17:59] ---
    That's how each and every one of us
    eventually becomes a full-fledged cell.
[18:08] ---
    Right.
[18:09] ---
    The future of this world
    rest on the shoulders of you youngsters.
[18:14] ---
    I'm counting on you, rookie.
[18:20] ---
    I'm really sorry.
[18:22] ---
    For being so rude to you just now.
[18:25] ---
    Don't worry about it. That's how harsh
    the conditions you're fighting under are.
[18:29] ---
    Come detox yourself anytime, okay?
[18:32] ---
    Okay! Thank you very much!
[18:34] ---
    Well, now we're refreshed.
    Why don't we head out now?
[18:37] ---
    Hey, come on. Let's go, Gramps.
[18:41] ---
    Gramps?
[18:47] ---
    So, he's passed away.
[18:51] ---
    Thank you for your long years of hard work.
[18:57] ---
    No way.
[18:59] ---
    Take him to the sinusoid.
[19:15] ---
    Who's that?
[19:16] ---
    That's the Kupffer Cell.
[19:19] ---
    She devours Red Blood Cells
    who've completed their missions.
[19:22] ---
    What?
[19:23] ---
    Kupffer Cell.
[19:25] ---
    A type of Macrophage
    that exists in the sinusoid.
[19:29] ---
    It activates by ingesting foreign particles.
[19:32] ---
    Aging Red Blood Cells are also ingested
    to produce bile pigment from hemoglobin.
[19:40] ---
    This is the life of a Red Blood Cell.
[19:42] ---
    We deliver oxygen until we die,
    and we get used as nutrients afterwards.
[19:48] ---
    Still, it's not a bad way to go, is it?
[19:53] ---
    Gramps...
[19:55] ---
    sure did look content.
[20:08] ---
    Goodbye, rookie.
    I'll be waiting for you.
[20:12] ---
    Okay!
[20:16] ---
    Good luck at work.
[20:24] ---
    White Blood Cell!
[20:27] ---
    Oh hey, it's not what you...
[20:30] ---
    I came to patrol the fatty liver.
[20:33] ---
    It could trigger cirrhosis
    if we just leave it.
[20:35] ---
    O-Oh, is that right?
[20:37] ---
    Come to think of it, seems like
    a lot of alcohol rained down.
[20:41] ---
    Are you all right?
[20:42] ---
    Yes. Um, thanks to Hepatocyte.
[20:46] ---
    I see.
[20:47] ---
    But don't let your guard down.
[20:53] ---
    Hey, you rookies, are you okay?
[20:56] ---
    I feel sick.
[20:59] ---
    Not all of the acetaldehyde
    got broken down, huh?
[21:05] ---
    Hangover.
[21:06] ---
    While traces of acetaldehyde
    remain in the body,
[21:09] ---
    its toxins trigger headaches and nausea.
[21:14] ---
    You know this doesn't mean
    that you can take a break, right?
[21:18] ---
    We know.
[21:20] ---
    All right, deliver that oxygen!
    Take Gramps's share with you!
[21:23] ---
    - Right!
    - Right!
[21:25] ---
    There are all kinds of jobs in this world.
[21:28] ---
    I want to see it through.
[21:30] ---
    By becoming a full-fledged Red Blood Cell.
[21:34] ---
    Huh? Alcohol?
[21:35] ---
    Come on! Again?
[21:38] ---
    Hair of the dog.
[21:39] ---
    Long touted as a remedy for easing hangover
    symptoms, though there is no scientific basis for this.
[21:46] ---
    It can be assumed that one is only gaining relief from
    headaches and nausea thanks to being intoxicated.
[23:19] ---
    PREVIEW
[23:20] ---
    Due to this body
    engaging in sexual reproduction...
[23:23] ---
    it is now in a state of arousal.
[23:23] ---
    EXCITEMENT
[23:25] ---
    Go off and become men!
[23:26] ---
    EXPANSION
[23:29] ---
    EMPTINESS
[23:29] ---
    Why were they ever born in this world, then?
[23:31] ---
    EXCITEMENT, EXPANSION, AND EMPTINESS