# E2 - The Liver, Alcohol, and Pride
Source: [Crunchyroll](https://www.crunchyroll.com/watch/G31UXPDZN/the-liver-alcohol-and-pride)
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(Please feel free to edit the speaker names if incomplete or inaccurate. Names are handled on a best-effort basis depending on the info on the source file. Dialogue is left as is.)
**[00:01] ---**
For your next deliveries, you'll be
going here, here, here and here.
**[00:05] ---**
This many?
**[00:06] ---**
You've got a problem?
**[00:08] ---**
This is me giving you a lighter load
since you're a rookie.
**[00:11] ---**
Right.
**[00:13] ---**
I'll be heading out now.
**[00:14] ---**
Whatever you do, don't forget
to get those receipts stamped!
**[00:17] ---**
R-Right.
**[00:20] ---**
Am I ever going to be done?
**[00:22] ---**
Hey, rookie, could you be any slower?
**[00:26] ---**
- Sorry!
- I don't believe it.
**[00:28] ---**
You haven't even gotten through
half of your quota yet!
**[00:31] ---**
What kind of plan do you have
for delivering this oxygen anyway?
**[00:35] ---**
- Or maybe you're just slacking off?
- I am not—
**[00:38] ---**
Oh well, what do I care?
**[00:40] ---**
Why don't you start
by picking up the pace?
**[00:42] ---**
Here, I'm adding these, too.
**[00:44] ---**
Huh?
**[00:45] ---**
I know you can do it!
**[00:46] ---**
Prove to me that
you haven't been slacking off, okay?
**[00:51] ---**
I see you're having a hard time, too, huh?
**[00:53] ---**
Yeah.
**[00:55] ---**
Talk about overwhelmed!
**[02:33] ---**
EPISODE 2:
THE LIVER, ALCOHOL, AND PRIDE
**[02:33] ---**
Okay, let's get going.
**[02:34] ---**
Sure. See ya.
**[02:35] ---**
See ya.
**[02:38] ---**
Th-That's a Macrophage.
**[02:41] ---**
They're all so pretty.
**[02:44] ---**
Huh?
**[02:50] ---**
What?
**[02:51] ---**
*Macrophage.*
**[02:53] ---**
*A type of White Blood Cell.*
**[02:55] ---**
*Catches and kills
foreign substances like bacteria,*
**[02:58] ---**
*while determining antigens
and information about immune responses.*
**[03:01] ---**
I have to kill more. More...
**[03:10] ---**
Oh my, so you're a Red Blood Cell.
**[03:13] ---**
Y-Yes.
**[03:15] ---**
I thought you were a bacterium!
**[03:17] ---**
My sincerest apologies.
**[03:23] ---**
Man, that Macrophage is exhausted, too.
**[03:28] ---**
Next is the Mucosal Cell in the oral cavity.
**[03:31] ---**
ORAL MUCOSAL EPITHELIUM
**[03:31] ---**
This way, huh?
**[03:33] ---**
Mucosal Cell?
I've come to deliver your oxy—
**[03:38] ---**
It's on fire?
**[03:39] ---**
*Mouth ulcer.*
**[03:41] ---**
*An inflammation inside of the mouth
or on the tongue.*
**[03:43] ---**
*When the lesions are round, shallow
and have a distinct border,*
**[03:47] ---**
*they are called "aphthous."*
**[03:49] ---**
*Often caused by stress, sleep deprivation
and lack of oral hygiene.*
**[03:55] ---**
A-Are you Mucosal Cell?
**[03:58] ---**
*Oral mucosa.*
**[03:59] ---**
*The mucous membrane
lining the inside of the mouth.*
**[04:02] ---**
*Also known as the mirror
reflecting one's physical health.*
**[04:06] ---**
WORKFLOW MANUAL
FOR RED BLOOD CELLS
**[04:06] ---**
When this kind of thing happens...
**[04:11] ---**
DURING DELIVERIES,
TRANSFERAL OF THE OXYGEN
MUST BE YOUR TOP PRIORITY!
**[04:11] ---**
"Top priority"?
**[04:15] ---**
Your seal...
**[04:17] ---**
U-Um, th-this receipt...
**[04:21] ---**
Please stamp this receipt!
**[04:27] ---**
The receipt!
**[04:34] ---**
*Don't worry about stuff like that!*
**[04:36] ---**
*All we need to do is suppress our emotions
and deliver oxygen in silence!*
**[04:42] ---**
No way can I do that.
**[04:44] ---**
No way.
**[04:46] ---**
- Run.
- What?
**[04:48] ---**
The mouth ulcer ruptured.
**[04:50] ---**
We'll soon be invaded by bacteria!
**[05:06] ---**
Stay away!
**[05:08] ---**
Stay away from me!
**[05:14] ---**
White Blood Cell!
**[05:17] ---**
WHITE BLOOD CELL
**[05:24] ---**
That was uncalled for.
**[05:26] ---**
Hey, don't be that way, Senpai.
**[05:31] ---**
She's right. After all,
it was such a hassle getting here.
**[05:37] ---**
Th-Thank you so much!
**[05:39] ---**
You?
**[05:41] ---**
We've met before.
**[05:44] ---**
You remember me?
**[05:46] ---**
Too bad.
**[05:47] ---**
You get extra points for the glasses,
but you're too slim.
**[05:51] ---**
I hear you! If only he was
just a little more macho-looking, right?
**[06:04] ---**
*Phagocytosis or Phagocytic Effects.*
**[06:06] ---**
*When Phagocytes, such as Monocytes,
Macrophages and Neutrophils*
**[06:11] ---**
*engulf bacteria and other foreign
substances, and break them down.*
**[06:27] ---**
This is your precious oxygen, right?
**[06:29] ---**
Don't ever let it go even if it kills you.
**[06:31] ---**
R-Right!
**[06:35] ---**
Not good!
**[06:36] ---**
Hold onto something!
**[06:47] ---**
What's going on?
**[06:48] ---**
We're being engulfed by water and povidone-iodine
from the damaged area! This is...
**[06:53] ---**
It's gargling!
**[06:55] ---**
*Gargling.*
**[06:56] ---**
*To wash away bacteria and viruses
in the mouth,*
**[07:00] ---**
*preventing respiratory tract inflammation.
Various theories exist.*
**[07:03] ---**
*Povidone-iodine.*
**[07:05] ---**
*An antiseptic used in gargling solutions.*
**[07:08] ---**
*Though it has a unique scent,
it's highly effective as an antiseptic.*
**[07:13] ---**
- Where'd that come from?
- Jeez, that's gross.
**[07:23] ---**
Good job hanging onto that oxygen.
**[07:25] ---**
Y-Yes. Thank you very much.
**[07:29] ---**
Hang in there, rookie.
**[07:32] ---**
See you later, Glasses!
**[07:34] ---**
Build up that body of yours!
**[07:41] ---**
Hey, Glasses is totally staring at us!
**[07:44] ---**
Do you think maybe he's smitten with Senpai?
**[07:48] ---**
Save your breath, will you?
**[07:50] ---**
Right!
**[07:53] ---**
I'm so wiped.
**[07:55] ---**
No rest since Day One.
How many rounds do we have to do in a day?
**[08:01] ---**
I came this close to dying three times.
**[08:03] ---**
I'm telling you, I can't take
much more of this job.
**[08:06] ---**
Are you okay, rookies?
**[08:09] ---**
Oh, good work, sirs!
**[08:10] ---**
It's all right, stay seated. The stress is more intense
than usual today, so I bet it's a lot to take in, huh?
**[08:16] ---**
Just my veteran's gut,
but a day like this, it's going to rain.
**[08:20] ---**
Rain?
**[08:22] ---**
Wh-What's this?
**[08:24] ---**
Hey, simmer down. This is alcohol.
**[08:28] ---**
*Alcohol.*
**[08:30] ---**
*Upon entering the body,
it has the effect of alleviating tension*
**[08:33] ---**
*by temporarily improving circulation and inducing
the secretion of dopamine and serotonin.*
**[08:39] ---**
Alcohol?
**[08:41] ---**
You can count on this happening
after overwhelming stress.
**[08:45] ---**
Sure, it improves the circulation,
**[08:46] ---**
but then the body absorbs more fat,
making the blood all viscous.
**[08:50] ---**
At this rate, we'll be delivering alcohol
all over the body.
**[08:53] ---**
The other cells are going to be pissed.
**[08:55] ---**
This stupid job... This stupid job...
**[08:59] ---**
Why should we do it?
Give us some days off!
**[09:02] ---**
Give us a long weekend off!
**[09:04] ---**
I didn't... I didn't become
a Red Blood Cell for this!
**[09:14] ---**
Hey, hey, get a grip.
**[09:16] ---**
You're not used to alcohol, huh?
No way around it! Come with me.
**[09:21] ---**
Even we need a break sometimes, right?
**[09:25] ---**
How about we get some healing
and refresh ourselves?
**[09:30] ---**
We're here.
**[09:32] ---**
This is the liver.
**[09:33] ---**
LIVER
**[09:34] ---**
*The liver.*
**[09:35] ---**
*An organ that performs
a wide variety of functions,*
**[09:37] ---**
*such as the synthesis, excretion
and detoxification of substances.*
**[09:42] ---**
Woo-hoo! I've always wanted to visit the liver!
**[09:46] ---**
It sure is lively here.
**[09:46] ---**
BLOOD ALLEY
BILE TOWN
FIRST AVENUE
**[09:48] ---**
Well, of course.
The liver is the largest organ in the body.
**[09:53] ---**
Not only does it metabolize
the Big Three nutrients...
**[09:55] ---**
but it also handles all kinds of tasks
like producing bile and breaking down toxins.
**[10:01] ---**
So, it's a really crucial organ, huh?
**[10:04] ---**
Is this your first time, rookie?
**[10:06] ---**
Y-Yes.
**[10:07] ---**
Normally, I get by just dealing
with oxygen and nutrients, so—
**[10:13] ---**
We'll show you how to really have fun in the liver.
**[10:17] ---**
Hey! Why don't you detox with us,
Red Blood Cell gentlemen?
**[10:21] ---**
Come on, let's go!
**[10:23] ---**
Jeez, just can't get enough of that, huh, Gramps?
**[10:26] ---**
I'm coming! I'm coming!
**[10:28] ---**
Um, what do you mean by "detox"?
**[10:31] ---**
I brought along some youngsters. It's their first time,
so send them some sweet young things, okay?
**[10:36] ---**
Consider it done, since you're always
such good customers. This way, please.
**[10:44] ---**
Some guests have arrived!
**[10:47] ---**
Welcome!
**[11:03] ---**
You youngsters don't hold back
with your reactions. Good for you!
**[11:07] ---**
I-It's not like I'm reacting!
**[11:09] ---**
Thank you for your patience!
**[11:11] ---**
We'll be seating you in groups of three!
**[11:14] ---**
Hepatocytes, please take Table 3!
**[11:18] ---**
Welcome, Red Blood Cells.
**[11:22] ---**
Please refresh yourselves tonight.
**[11:25] ---**
*Hepatocytes.*
**[11:27] ---**
*Cells that make up 70 to 80% of the liver.*
**[11:31] ---**
*They metabolize and detoxify substances.*
**[11:35] ---**
- N-Nice to meet you.
- Is this your first time coming to a place like this?
**[11:39] ---**
Yes! It's our first time!
**[11:43] ---**
Wonderful, isn't it, rookie? Having a gorgeous
Hepatocyte like this help us detox!
**[11:48] ---**
What do you mean by "detox"?
**[11:51] ---**
Right, here you go.
**[11:52] ---**
Huh? What's this?
**[11:54] ---**
This is ADH.
**[11:56] ---**
ADH?
**[11:58] ---**
That's right. It's an enzyme
that breaks down alcohol.
**[12:02] ---**
*ADH.*
**[12:04] ---**
*An enzyme present in the Hepatocytes.*
**[12:06] ---**
*Has the ability to convert
alcohol into acetaldehyde.*
**[12:10] ---**
Alcohol is a substance
that triggers intoxication, right?
**[12:13] ---**
It's our job as Hepatocytes to break down
and detoxify alcohol in the blood to sober you up.
**[12:20] ---**
Oh, so that's what "detox" means.
**[12:23] ---**
Goro can't dwink ADH by himself!
**[12:27] ---**
Dwink?
**[12:28] ---**
What am I going to do with you?
Here, there you go!
**[12:36] ---**
Don't cringe at me, dummy!
**[12:38] ---**
When you're at a place like this,
just forget all about work and have a good time!
**[12:42] ---**
R-Right.
**[12:47] ---**
Forget all about work...
**[12:56] ---**
You really chugged that!
**[12:57] ---**
- That was hot!
- For real?
**[12:59] ---**
Gimme a "That's a good boy!"
**[13:02] ---**
That's a good boy!
**[13:04] ---**
What's wrong?
**[13:06] ---**
You have a frown on your face.
**[13:08] ---**
It's nothing.
**[13:10] ---**
You owe it to yourself to have some fun.
**[13:13] ---**
He's right! Drink up and refresh yourself!
**[13:15] ---**
Okay.
**[13:20] ---**
That was great!
Good job downing that!
**[13:23] ---**
I'm starting to feel queasy.
**[13:25] ---**
I'm telling you, I can't take it!
**[13:28] ---**
The blood vessels are so uneven,
trying to walk through them is a joke!
**[13:31] ---**
The higher-ups aren't giving us
a second thought!
**[13:35] ---**
Damn it! They have to improve
our working conditions or we can't go on!
**[13:41] ---**
That's right!
**[13:42] ---**
Don't we even get paid time off?
Where's our paid time off?
**[13:45] ---**
Wh-What's that?
That black haze...
**[13:48] ---**
That's acetaldehyde.
**[13:50] ---**
Huh?
**[13:51] ---**
Acetaldehyde is what you get
when alcohol is metabolized by ADH.
**[13:56] ---**
It's a powerful toxin,
but to eliminate alcohol completely,
**[14:00] ---**
you need to convert it
to this substance first.
**[14:03] ---**
*Acetaldehyde.*
**[14:05] ---**
*A highly toxic substance.*
**[14:08] ---**
*Can also be found in automobile
exhaust fumes and tobacco smoke.*
**[14:12] ---**
A toxin?
**[14:14] ---**
That's why everyone's pissed
and out of control.
**[14:17] ---**
All right, the next step is...
**[14:22] ---**
What's that?
**[14:23] ---**
An enzyme called "ALDH."
**[14:26] ---**
*ALDH.*
**[14:28] ---**
*An enzyme that metabolizes acetaldehyde
into acetic acid, detoxifying it.*
**[14:33] ---**
*Acetic acid is ultimately converted into water
and carbon dioxide, then expelled from the body.*
**[14:39] ---**
If you detoxify the acetaldehyde
by metabolizing it,
**[14:42] ---**
it will sober you up completely.
**[14:45] ---**
Now, does everyone have a glass of ALDH?
**[14:49] ---**
Once again, let's raise a glass
to working healthy again tomorrow!
**[14:54] ---**
Cheers!
**[14:55] ---**
Cheers!
**[15:00] ---**
*Transport the oxygen!*
**[15:16] ---**
How can I be in the mood to raise a glass?
**[15:21] ---**
Can we just erase it all with this enzyme?
**[15:24] ---**
All our suffering...
**[15:26] ---**
Rookie?
**[15:27] ---**
Every day, all we do
is run around delivering oxygen.
**[15:32] ---**
We're so easily replaceable.
**[15:35] ---**
One or two drops of blood being shed
isn't going to affect this body in any way!
**[15:40] ---**
Oh, don't talk like that.
In one go, all right?
**[15:44] ---**
What do you...
**[15:46] ---**
What do you people know about it?
**[15:50] ---**
Aren't the internal organs and the bowels
where the elite work?
**[15:53] ---**
A safe spot from where you can watch us
scrambling around?
**[15:56] ---**
People like you with such carefree jobs...
**[15:59] ---**
You don't know anything about our pain!
**[16:05] ---**
That's enough. You're a really bad drunk.
**[16:10] ---**
Are you all right?
**[16:12] ---**
I'll bring you another glass right away.
**[16:17] ---**
Rookie...
**[16:20] ---**
Come with me.
**[16:23] ---**
Are you all right?
**[16:25] ---**
I'm sorry.
There's been so much alcohol lately.
**[16:29] ---**
Why don't you take a break?
**[16:31] ---**
I'll be fine.
**[16:33] ---**
The other Hepatocytes have been hit hard by the
acetaldehyde toxins, but they're soldiering on.
**[16:40] ---**
*Liver failure.*
**[16:42] ---**
*Overconsumption of alcohol
can lead to a fatty liver*
**[16:46] ---**
*due to acetaldehyde inhibiting
the breakdown of fats.*
**[16:50] ---**
*Chronic binging will eventually destroy
the liver cells, triggering hepatic cirrhosis.*
**[16:58] ---**
We're not the only ones who are suffering.
**[17:01] ---**
The Red Blood Cells risk their lives
to work like crazy for us.
**[17:07] ---**
As long as they're here,
I don't want them to see me being weak.
**[17:16] ---**
I've seen all kinds of cells over the years,
**[17:19] ---**
but there isn't one single easy task
in this world.
**[17:22] ---**
Well, I guess you've been through a lot.
**[17:25] ---**
If an old geezer like me will do, talk to me.
**[17:30] ---**
I...
**[17:31] ---**
I...
**[17:33] ---**
I just ran off!
**[17:36] ---**
Bailing on the job I was supposed to do...
**[17:40] ---**
Because of that, S-Senpai...
**[17:44] ---**
My only task is to deliver oxygen,
but I can't even get that right!
**[17:49] ---**
I'm not blaming you.
**[17:52] ---**
The longer you live,
the more shame you suffer.
**[17:55] ---**
I've been scrambling around myself,
just like you.
**[17:59] ---**
That's how each and every one of us
eventually becomes a full-fledged cell.
**[18:08] ---**
Right.
**[18:09] ---**
The future of this world
rest on the shoulders of you youngsters.
**[18:14] ---**
I'm counting on you, rookie.
**[18:20] ---**
I'm really sorry.
**[18:22] ---**
For being so rude to you just now.
**[18:25] ---**
Don't worry about it. That's how harsh
the conditions you're fighting under are.
**[18:29] ---**
Come detox yourself anytime, okay?
**[18:32] ---**
Okay! Thank you very much!
**[18:34] ---**
Well, now we're refreshed.
Why don't we head out now?
**[18:37] ---**
Hey, come on. Let's go, Gramps.
**[18:41] ---**
Gramps?
**[18:47] ---**
So, he's passed away.
**[18:51] ---**
Thank you for your long years of hard work.
**[18:57] ---**
No way.
**[18:59] ---**
Take him to the sinusoid.
**[19:15] ---**
Who's that?
**[19:16] ---**
That's the Kupffer Cell.
**[19:19] ---**
She devours Red Blood Cells
who've completed their missions.
**[19:22] ---**
What?
**[19:23] ---**
*Kupffer Cell.*
**[19:25] ---**
*A type of Macrophage
that exists in the sinusoid.*
**[19:29] ---**
*It activates by ingesting foreign particles.*
**[19:32] ---**
*Aging Red Blood Cells are also ingested
to produce bile pigment from hemoglobin.*
**[19:40] ---**
This is the life of a Red Blood Cell.
**[19:42] ---**
We deliver oxygen until we die,
and we get used as nutrients afterwards.
**[19:48] ---**
Still, it's not a bad way to go, is it?
**[19:53] ---**
Gramps...
**[19:55] ---**
sure did look content.
**[20:08] ---**
Goodbye, rookie.
I'll be waiting for you.
**[20:12] ---**
Okay!
**[20:16] ---**
Good luck at work.
**[20:24] ---**
White Blood Cell!
**[20:27] ---**
Oh hey, it's not what you...
**[20:30] ---**
I came to patrol the fatty liver.
**[20:33] ---**
It could trigger cirrhosis
if we just leave it.
**[20:35] ---**
O-Oh, is that right?
**[20:37] ---**
Come to think of it, seems like
a lot of alcohol rained down.
**[20:41] ---**
Are you all right?
**[20:42] ---**
Yes. Um, thanks to Hepatocyte.
**[20:46] ---**
I see.
**[20:47] ---**
But don't let your guard down.
**[20:53] ---**
Hey, you rookies, are you okay?
**[20:56] ---**
I feel sick.
**[20:59] ---**
Not all of the acetaldehyde
got broken down, huh?
**[21:05] ---**
*Hangover.*
**[21:06] ---**
*While traces of acetaldehyde
remain in the body,*
**[21:09] ---**
*its toxins trigger headaches and nausea.*
**[21:14] ---**
You know this doesn't mean
that you can take a break, right?
**[21:18] ---**
We know.
**[21:20] ---**
All right, deliver that oxygen!
Take Gramps's share with you!
**[21:23] ---**
- Right!
- Right!
**[21:25] ---**
*There are all kinds of jobs in this world.*
**[21:28] ---**
*I want to see it through.*
**[21:30] ---**
*By becoming a full-fledged Red Blood Cell.*
**[21:34] ---**
Huh? Alcohol?
**[21:35] ---**
Come on! Again?
**[21:38] ---**
*Hair of the dog.*
**[21:39] ---**
*Long touted as a remedy for easing hangover
symptoms, though there is no scientific basis for this.*
**[21:46] ---**
*It can be assumed that one is only gaining relief from
headaches and nausea thanks to being intoxicated.*
**[23:19] ---**
PREVIEW
**[23:20] ---**
Due to this body
engaging in sexual reproduction...
**[23:23] ---**
it is now in a state of arousal.
**[23:23] ---**
EXCITEMENT
**[23:25] ---**
Go off and become men!
**[23:26] ---**
EXPANSION
**[23:29] ---**
EMPTINESS
**[23:29] ---**
Why were they ever born in this world, then?
**[23:31] ---**
EXCITEMENT, EXPANSION, AND EMPTINESS