# E1 - Smoking, Bacteria, and the Beginning of the End
Source: [Crunchyroll](https://www.crunchyroll.com/watch/GVWU0V547/smoking-bacteria-and-the-beginning-of-the-end)
Translator:
Editor:
Timer:
QC:
(Please feel free to edit the speaker names if incomplete or inaccurate. Names are handled on a best-effort basis depending on the info on the source file. Dialogue is left as is.)
**[00:19] ---**
*I work...*
**[00:21] ---**
WHITE BLOOD CELL
**[00:22] ---**
*and work...*
**[00:28] ---**
*and work...*
**[00:35] ---**
What are you doing?
Deliver that oxygen!
**[00:38] ---**
I work and work and work...
**[00:42] ---**
but it doesn't make any difference!
**[00:44] ---**
Just what is it that we're all working for?
**[00:49] ---**
You have to keep on working anyway.
**[00:57] ---**
As long as you have a job to do.
**[01:07] ---**
Cells at Work!
CODE BLACK
**[01:09] ---**
EPISODE 1:
SMOKING, BACTERIA,
AND THE BEGINNING OF THE END
**[01:12] ---**
Welcome, everyone.
**[01:14] ---**
Now that you've graduated
from Erythroblast status,
**[01:17] ---**
as of today, you'll be working
with us as Red Blood Cells.
**[01:21] ---**
We have great expectations of you all
as you work for the bright future of this world!
**[01:28] ---**
Since we all share the same mission,
we are like family.
**[01:32] ---**
Let's help each other out,
join forces and do our best together.
**[01:45] ---**
CELL
**[01:47] ---**
*This is the body in which
you'll be working, starting today.*
**[01:51] ---**
*Throughout the film you're about to see,*
**[01:53] ---**
*we'll be introducing you to the various systems
and cells inside this body.*
**[01:58] ---**
*First, the path that you Red Blood Cells will be taking
to deliver oxygen, the blood vessel.*
**[02:03] ---**
*A route not only for you...*
**[02:05] ---**
*but also for the White Blood Cells who eliminate
foreign substances that enter the body...*
**[02:09] ---**
*the Killer T Cells who eliminate cells
infected by viruses...*
**[02:14] ---**
*and the Macrophages
who clean up the body.*
**[02:17] ---**
*As you can see,
it's a pathway for all types of cells.*
**[02:20] ---**
*And these are the Platelets
who work to repair damaged blood vessels.*
**[02:21] ---**
PLATELETS
**[02:25] ---**
*- Hello!
- Hello!*
**[02:28] ---**
*They just said hello to us!*
**[02:30] ---**
*Greetings are essential if you're going
to have a good day at work, right?*
**[02:34] ---**
*And here are the internal organs
which are indispensable for the work you'll be doing.*
**[02:40] ---**
Each one serves its own crucial role...
**[02:43] ---**
*and it's here that you'll find the cells*
**[02:45] ---**
*who can be considered specialists
in their respective fields at work.*
**[02:48] ---**
*Among them are organs
that will look after your Red Blood Cells.*
**[02:55] ---**
Can't wait for that!
**[02:57] ---**
Yep.
**[02:58] ---**
*And now, why don't we hear
from one of them?*
**[03:01] ---**
*Gastric Chief Cell will speak to us now.*
**[03:04] ---**
*What are you doing right now?*
**[03:06] ---**
*This here's digestion.*
**[03:08] ---**
*It's an important process
for absorbing nutrients.*
**[03:13] ---**
*Can you say a few words
to our newly-joined Red Blood Cells?*
**[03:17] ---**
*Let's see.*
**[03:20] ---**
*When you come to the stomach
to make deliveries, tell us your names.*
**[03:24] ---**
*It's a lot more pleasant to work
with a familiar face*
**[03:26] ---**
*than with someone
you don't even know by name.*
**[03:30] ---**
*We'll be waiting for you guys!*
**[03:34] ---**
*You may work in different systems,
but you're all friends working in the same body.*
**[03:39] ---**
*By interacting,
you can improve the work environment.*
**[03:47] ---**
That's it for our introductory video.
**[03:49] ---**
You will now separate into groups,
and start your on-the-job training.
**[03:53] ---**
Any questions?
**[03:55] ---**
Yes!
**[03:56] ---**
Go on.
**[03:56] ---**
Uh, can you tell us
how much overtime to expect?
**[04:00] ---**
We can't say that there won't be any,
**[04:02] ---**
but we've been working toward
reducing overtime as much as possible.
**[04:05] ---**
You know, what they call "work-style reforms."
**[04:07] ---**
Seriously? Good to know!
**[04:10] ---**
Efficient, shortened workdays
and increased benefits are part of our plan
**[04:15] ---**
to provide you with security
in the workplace.
**[04:21] ---**
Hey, this job's gonna be easier than I thought!
**[04:24] ---**
Uh, yeah.
**[04:26] ---**
It seems like a friendly environment,
**[04:27] ---**
and the people from the other systems
seemed nice, too.
**[04:31] ---**
Hey, what are you looking at?
**[04:33] ---**
I need to learn all our delivery destinations.
**[04:35] ---**
How serious are you?
Can't we just figure that out during OJT?
**[04:40] ---**
Well, yeah, I guess.
**[04:42] ---**
We have one simple job, delivering oxygen,
so there's no need to get so gung-ho about it.
**[04:49] ---**
You're late, rookies.
**[04:52] ---**
Oh, are you the senpais
who'll be training us in the field?
**[04:54] ---**
Grab your oxygen now. Come on.
**[04:57] ---**
Hurry up! Two boxes per person!
**[04:59] ---**
R-Right!
**[05:03] ---**
What are we going to do now?
**[05:05] ---**
Your jobs, what else?
Transport that oxygen.
**[05:08] ---**
We're working already?
**[05:10] ---**
But we heard that we'd be training—
**[05:12] ---**
We don't have time to train you.
Learn on the job.
**[05:16] ---**
This body is short on both manpower and time.
Now get going.
**[05:20] ---**
Huh? What about the work-style reforms?
**[05:23] ---**
All you're ever going to find here
is never-ending toil.
**[05:26] ---**
Huh?
**[05:27] ---**
If you're a Red Blood Cell,
**[05:29] ---**
then deliver, deliver,
deliver oxygen until you drop!
**[05:37] ---**
*The aortic valve will now open.*
**[05:40] ---**
*Let's make today
another day without injuries...*
**[05:44] ---**
*and work energetically
with a smile on our faces!*
**[05:48] ---**
Go! Go! Go!
Run! Run! Run!
**[05:50] ---**
Run until you drop! Work!
**[05:53] ---**
Keep working until your strength is sapped!
**[05:57] ---**
*This is the moment that it started.*
**[06:00] ---**
*The black labor within this body!*
**[06:07] ---**
This is rough!
**[06:08] ---**
Don't slow down! Hurry up!
**[06:10] ---**
Right!
**[06:11] ---**
What is this? I never signed up
for anything like this!
**[06:15] ---**
Idiot!
**[06:16] ---**
AC1677! You need to go this way!
**[06:19] ---**
Right.
**[06:25] ---**
Which way is the stomach?
**[06:30] ---**
You're in our way! Move it!
**[06:32] ---**
Oh! Sorry!
**[06:35] ---**
Platelet, hello—
**[06:37] ---**
Just skip the formalities and get out
of our way! Get a life, will you?
**[06:41] ---**
Oh, hey, I'm sorry!
**[06:46] ---**
Sorry about that.
It's just that we're in a hurry.
**[06:53] ---**
*The stomach. Stores all ingested food
and disinfects it with gastric acid secretions.*
**[07:01] ---**
*In addition, a digestive enzyme called "pespin"
breaks down food, turning it into a paste,*
**[07:08] ---**
*thus completing the first stage of digestion.*
**[07:11] ---**
Sorry to keep you waiting for your oxygen.
**[07:14] ---**
Oh, you were in that training video.
**[07:18] ---**
You're too damn slow!
**[07:19] ---**
How long does it take
to deliver one canister of oxygen?
**[07:23] ---**
I'm sorry.
I only just started working today—
**[07:26] ---**
What do I care? Once you're in the field,
it doesn't matter if you're a rookie or a veteran!
**[07:31] ---**
Right! Sorry!
**[07:33] ---**
Oh, and also... this is my first day,
and I'm AA2153.
**[07:38] ---**
Huh?
**[07:39] ---**
Th-That's my name.
**[07:41] ---**
Who the cell has time to remember names?
**[07:43] ---**
Every one of you has
the same damn face and name!
**[07:46] ---**
Read the room, will you?
**[07:48] ---**
But in that video, you said
you wanted to know our names.
**[07:51] ---**
Huh? They're still using that thing?
From ages ago?
**[07:56] ---**
What?
**[07:57] ---**
Since we recorded that video, this body's gone
so downhill, you can't even compare it to before!
**[08:03] ---**
I don't have a second to spare like I did then.
**[08:06] ---**
How did that happen?
**[08:08] ---**
Not just fatigue, but sleep deprivation to boot.
**[08:12] ---**
Not to mention excessive eating and drinking.
**[08:15] ---**
No matter how hard we work,
it's only getting worse and worse.
**[08:19] ---**
But...
**[08:21] ---**
Now you know, so next time,
bring that oxygen faster!
**[08:23] ---**
R-Right!
**[08:37] ---**
Hey, Red Blood Cell!
**[08:39] ---**
You've really been skimping
on the oxygen supply lately!
**[08:42] ---**
I'm sorry. We've been ordered to prioritize
deliveries to the main organs, so...
**[08:48] ---**
Huh? So, the cells in the extremities
can just die, is that it?
**[08:51] ---**
P-Please forgive me.
**[08:55] ---**
Really sorry about this.
**[08:58] ---**
We'll be able to provide you
with a massive supply of fresh oxygen soon,
**[09:01] ---**
and you'll be first on our list.
**[09:03] ---**
Really?
**[09:04] ---**
This is just a special deal for you, ma'am.
**[09:07] ---**
Now, then, we'll be off.
Let's go, rookie.
**[09:14] ---**
Thank you very much, Senpai.
**[09:16] ---**
So, there's going to be
a massive supply of fresh oxygen?
**[09:19] ---**
No, I made that up.
**[09:21] ---**
Huh?
**[09:22] ---**
Well, we'd never get anything done
if we actually listened to all the complaints.
**[09:25] ---**
Oh, so that's it?
**[09:27] ---**
Oh, I'm sorry to make you carry the oxygen!
**[09:32] ---**
Hold it diagonally, like this,
and it'll be more stable.
**[09:35] ---**
Hey, you're right!
**[09:38] ---**
You were out of luck,
starting here at a time like this.
**[09:41] ---**
Normally, it's part of our job to show
the ropes to the rookies...
**[09:45] ---**
but there isn't a single person here
who has that kind of time.
**[09:49] ---**
Why are we so short-handed?
**[09:52] ---**
It's probably due to stress.
**[09:54] ---**
To prioritize the vitals,
there's been less bloodflow to the extremities.
**[09:59] ---**
Years ago, this body was nothing like this.
**[10:04] ---**
Let's go! The higher-ups will give us an earful
if we don't fulfill our quotas, right?
**[10:09] ---**
Senpai!
**[10:10] ---**
Senpai, how can you possibly smile
when things are like this?
**[10:15] ---**
Hey, it's simple!
**[10:17] ---**
All you have to do
is suppress your emotions.
**[10:19] ---**
Huh?
**[10:20] ---**
"I want to rest."
"I want to have an easy time."
**[10:23] ---**
Hoping for that kind of thing
is what brings you anguish.
**[10:26] ---**
If you suppress all of your emotions,
you can keep smiling.
**[10:33] ---**
True. His eyes aren't smiling.
**[10:39] ---**
What's going on here?
The vessel's all bumpy!
**[10:43] ---**
Watch your step, rookie.
**[10:45] ---**
Okay.
**[10:49] ---**
Hey, dummy!
**[10:50] ---**
Don't ever let go of that oxygen!
It's more precious than life itself!
**[10:55] ---**
Is that the LDL guys?
**[10:57] ---**
Hey, come back here!
**[10:59] ---**
Get a hold of yourself. Can you stand?
**[11:01] ---**
Yes.
**[11:02] ---**
Who were they?
**[11:03] ---**
LDL. The bad cholesterol guys.
**[11:07] ---**
That was them illegally disposing
of cholesterol secreted by the liver.
**[11:11] ---**
Illegal disposal?
**[11:12] ---**
Seriously, if this ends up blocking the vessel
and causing arterial sclerosis,
**[11:17] ---**
we won't be able to get through.
**[11:19] ---**
Won't be able to get through?
**[11:21] ---**
Because of oxidation in the body.
**[11:23] ---**
Oxidation...
**[11:25] ---**
This is also due to stress.
**[11:27] ---**
Stress generates increased levels of active oxygen,
creating bumps on the vessel walls.
**[11:34] ---**
That's why it's so bumpy.
**[11:37] ---**
And now that resistance is also low,
I hear that more germs have shown up.
**[11:42] ---**
Germs...
**[11:45] ---**
Um...
**[11:47] ---**
This body...
**[11:50] ---**
Is it going to be all right?
**[11:53] ---**
Don't worry about stuff like that!
**[11:56] ---**
All we need to do is suppress our emotions
and deliver oxygen in silence!
**[12:07] ---**
We're back.
So, I've gone around once.
**[12:11] ---**
You can take a break
before starting the second round.
**[12:14] ---**
Okay.
**[12:15] ---**
I'm going to take a look over there.
**[12:18] ---**
I'm exhausted.
**[12:21] ---**
- Get up.
- Huh?
**[12:22] ---**
Who said you could take a break?
**[12:25] ---**
We don't have time for breaks!
**[12:28] ---**
Huh? Um...
**[12:31] ---**
Hey, come on.
**[12:32] ---**
He just went around the whole body on his first job.
Of course, that's got to tire him out some...
**[12:37] ---**
It's too soon to whine and give up.
**[12:39] ---**
We've got to make so many trips
around the body a day.
**[12:43] ---**
When we were rookies, we took it easier—
**[12:46] ---**
And we're paying for that now, aren't we?
**[12:50] ---**
If you have time to reminisce
about the old days, get moving.
**[12:55] ---**
I can go.
**[13:01] ---**
Don't coddle the rookies anymore.
**[13:09] ---**
If I'm not mistaken,
the road splits off up ahead
**[13:12] ---**
into the carotid artery leading to the head,
and the descending aorta leading to the torso.
**[13:16] ---**
Good job, rookie!
**[13:18] ---**
This time, we're going to pass through
the digestive system from the descending aorta
**[13:21] ---**
to get back to the heart.
**[13:22] ---**
Okay!
**[13:27] ---**
Wh-What's that gas?
**[13:41] ---**
- Are you all right?
- Idiot!
**[13:43] ---**
Don't go near him!
This is carbon monoxide!
**[13:46] ---**
Carbon monoxide?
**[13:48] ---**
Us Red Blood Cells contain
tons of hemoglobin.
**[13:52] ---**
Hemoglobin has a binding affinity
with carbon monoxide!
**[13:56] ---**
*Hemoglobin. The protein containing
the red pigment that gives blood its red color.*
**[14:02] ---**
*By binding with oxygen, it enables Red Blood Cells
to transport oxygen throughout the body.*
**[14:08] ---**
If we bind with carbon monoxide,
we won't be able to deliver oxygen!
**[14:12] ---**
Huh?
**[14:13] ---**
Meaning that the body will become
oxygen-deprived!
**[14:17] ---**
Carbon monoxide detected
within the blood vessel!
**[14:19] ---**
Irritation to the central nervous system!
**[14:21] ---**
It seems like some kind of toxin
has been introduced.
**[14:23] ---**
A toxin?
**[14:25] ---**
The heart rate's going up!
Blood pressure rising!
**[14:27] ---**
The capillaries are constricting!
**[14:30] ---**
Wh-What's going on? The walls are...
**[14:35] ---**
Have you analyzed the toxin?
**[14:37] ---**
The acetylcholine receptors
are in a state of agitation,
**[14:40] ---**
and the chain of command
has been disrupted!
**[14:43] ---**
*Acetylcholine receptors.*
**[14:46] ---**
*They exist in the synapses
and are made of protein.*
**[14:50] ---**
*They receive the neurotransmitter
acetylcholine...*
**[14:53] ---**
*sending signals across the nerve network,*
**[14:56] ---**
*and controlling the smooth muscles,
skeletal muscles and sweat glands.*
**[15:01] ---**
The acetylcohline receptors
have been affected? Don't tell me it's...
**[15:06] ---**
E-Everybody?
**[15:09] ---**
W-We have to save them!
**[15:14] ---**
It's too late!
**[15:15] ---**
These guys have turned
into carboxyhemoglobin!
**[15:18] ---**
*Carboxyhemoglobin.*
**[15:21] ---**
*Formed when hemoglobin binds
with carbon monoxide.*
**[15:24] ---**
*Red Blood Cells are unable
to deliver oxygen in this state.*
**[15:29] ---**
But where did this carbon monoxide come from?
**[15:33] ---**
Senpai!
**[15:34] ---**
Look.
**[15:36] ---**
Huh?
**[15:39] ---**
Bacteria's reached the blood vessel...
at a time like this?
**[15:43] ---**
Bacteria?
**[15:46] ---**
Those are Pneumococci!
**[15:48] ---**
*Pneumococci. Pathogenic bacteria that trigger
pneumonia, septicemia and the like.*
**[15:54] ---**
*A highly durable and toxic bacteria.*
**[16:06] ---**
What should we do?
**[16:07] ---**
Nothing we can do but run.
**[16:10] ---**
They attack cells, seeking nutrients!
**[16:12] ---**
We're going to end up
getting ruptured, too!
**[16:26] ---**
That's...
**[16:31] ---**
A cleaner cell who eliminates
germs from the body...
**[16:35] ---**
White Blood Cell!
**[16:40] ---**
*White Blood Cell or Neutrophil.*
**[16:43] ---**
*Its main job is to eliminate foreign substances*
**[16:45] ---**
*such as bacteria and viruses
that have invaded the body from the outside.*
**[16:50] ---**
Sorry I got here late.
**[16:52] ---**
The germs have been proliferating all over the place,
so we've been really swamped.
**[17:00] ---**
Are you a rookie?
**[17:01] ---**
Y-Yes.
**[17:05] ---**
Let me take care of this.
**[17:19] ---**
Let's go, rookie.
**[17:20] ---**
Huh? Go where?
**[17:22] ---**
Where do you think?
**[17:25] ---**
We're going to deliver this oxygen.
**[17:27] ---**
If the delivery of oxygen is halted,
the cells will die of necrosis.
**[17:32] ---**
Our job doesn't allow for breaks.
**[17:34] ---**
B-But...
**[17:36] ---**
In a situation like this,
even if we're under orders...
**[17:40] ---**
You must be kidding me!
I can't take this job anymore!
**[17:46] ---**
Don't ever forget this, rookie.
**[17:49] ---**
The moment us Red Blood Cells mature,
**[17:53] ---**
we discard everything that normal cells have.
**[17:56] ---**
Our cell nuclei, our mitochondria,
all of our organelles.
**[17:59] ---**
And we become cells that are 90% hemoglobin,
cells that are dedicated to delivering oxygen.
**[18:06] ---**
We spend our entire lives
delivering oxygen to the entire body,
**[18:09] ---**
traveling the same route
over and over 200,000... 300,000 times!
**[18:14] ---**
This isn't an order.
**[18:17] ---**
There's nothing else that we can do!
**[18:22] ---**
Don't think about anything,
suppress your emotions and transport the oxygen!
**[18:27] ---**
We don't need any wimps here.
**[18:29] ---**
You retrieve the oxygen and take
the descending aorta to head back to the lungs.
**[18:34] ---**
Huh?
**[18:34] ---**
That route is still safe.
**[18:37] ---**
I'll take the carotid artery
to transport your oxygen to the brain.
**[18:41] ---**
Because the brain cells are our top priority.
**[18:43] ---**
The carotid artery?
**[18:48] ---**
White Blood Cell Lady!
**[18:50] ---**
We're counting on you!
**[18:52] ---**
Senpai, it's no good! If you do that—
**[18:55] ---**
I'm leaving the rest to you.
**[18:57] ---**
Make sure you become a fine Red Blood Cell.
**[19:00] ---**
Sorry I couldn't pass the baton to you
in a better environment.
**[19:04] ---**
Senpai!
**[19:25] ---**
Emotions...
**[19:27] ---**
No way is it easy to suppress them.
**[19:30] ---**
Not for any cell...
**[19:37] ---**
Senpai!
**[19:40] ---**
Don't let his resolve have been for nothing.
**[19:43] ---**
Come with me.
**[19:48] ---**
*The carbon monoxide advisory
has been lifted.*
**[19:50] ---**
*All cells, please be careful
when you head outside!*
**[19:54] ---**
Have you calmed down a little?
**[19:56] ---**
Yes. Thank you for saving me,
White Blood Cell.
**[20:01] ---**
I just did my job, that's all.
**[20:04] ---**
Um, White Blood Cell?
**[20:08] ---**
Are our jobs really worth
risking our lives for?
**[20:17] ---**
We might be working
so that we can find the answer to that.
**[20:22] ---**
Where are you going?
**[20:24] ---**
To the lungs. I'm going to see
what caused the carbon monoxide outbreak.
**[20:31] ---**
*Lungs.*
**[20:32] ---**
*The organs that absorb oxygen
from the air into the body...*
**[20:36] ---**
*and expel the carbon dioxide delivered
by the Red Blood Cells back into the air.*
**[20:44] ---**
How did it get so dirty?
**[20:46] ---**
Today's emergency was caused by smoking.
For the first time in ten years, that is.
**[20:51] ---**
Smoking?
And this has happened before?
**[20:54] ---**
Look up there.
That's the grime from before.
**[20:58] ---**
Just when it was finally starting to get clean...
**[21:01] ---**
I hear that they detected nicotine,
**[21:02] ---**
a toxin that affects the acetylcholine
receptors in the nerve tract.
**[21:08] ---**
Why would this body deliberately
ingest something like that?
**[21:12] ---**
Because one of its effects
is temporary pleasure.
**[21:16] ---**
Not only that,
but nicotine is also addictive.
**[21:20] ---**
The same thing is going to happen
again and again.
**[21:23] ---**
You should keep that in mind.
**[21:24] ---**
B-But...
**[21:29] ---**
*Red Blood Cells, receive your oxygen at once
and deliver it to the entire body!*
**[21:34] ---**
*Repeat, receive your oxygen at once
and deliver it to the entire body!*
**[21:39] ---**
*The resumption of smoking
after ten years...*
**[21:42] ---**
*That was only the beginning
of the dangers awaiting this body.*
**[23:19] ---**
PREVIEW
**[23:20] ---**
No way!
**[23:21] ---**
I've always wanted to visit the liver!
**[23:22] ---**
LIVER
**[23:24] ---**
Calm down.
**[23:26] ---**
This is alcohol.
**[23:26] ---**
ALCOHOL
**[23:28] ---**
PRIDE
**[23:28] ---**
As long as they're here,
I don't want them to see my weak side.
**[23:31] ---**
THE LIVER, ALCOHOL, AND PRIDE